A5023891526- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- French Urban and Social Studies
- Cancer therapeutics and mechanisms
- Lignin and Wood Chemistry
- Forest ecology and management
- Phytochemicals and Antioxidant Activities
- Forest Management and Policy
- Protein Tyrosine Phosphatases
- Jewish and Middle Eastern Studies
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Erythrocyte Function and Pathophysiology
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Middle East Politics and Society
- Middle East and Rwanda Conflicts
- Liver physiology and pathology
- Wood Treatment and Properties
- Multiculturalism, Politics, Migration, Gender
- Pharmacogenetics and Drug Metabolism
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
Merck (Germany)
2016-2023
Simcyp (United Kingdom)
2020
Medicines for Malaria Venture
2020
Mondeca (France)
2018
Université de Lorraine
2006-2017
University of Liège
2004-2016
AgroBio
2015-2016
Laboratoire d'Etude et de Recherche sur le Matériau Bois
2002-2016
Gembloux Agro-Bio Tech
1997-2009
Pierre Fabre (France)
1996-2009
The optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP) is unknown. Shortening the length may help to contain emergence multiresistant bacteria in intensive care unit (ICU).To determine whether 8 days as effective 15 antibiotic patients with microbiologically proven VAP.Prospective, randomized, double-blind (until day 8) clinical trial conducted 51 French ICUs. A total 401 diagnosed having developed VAP by quantitative culture results bronchoscopic specimens...
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitive PI3Kgamma inhibitors. Structure-based design X-ray crystallography complexes formed by inhibitors bound to identified key pharmacophore features potency selectivity. An acidic NH group on the thiazolidinedione moiety hydroxy furan-2-yl-phenyl...
Pistacia lentiscus (Anacardiaceae) is commonly used in folk medicine to treat various diseases. The aim of the present study was evaluate hepatoprotective and antioxidant activities extracts P. leaves (PL) fruits (PF) against experimentally induced liver damage. Furthermore, characterization attempted by a spectroscopic methodology (Fourier transform infrared spectroscopy) high-performance liquid chromatography with diode array detection analysis. A potential paracetamol [165 mg/kg body...
The present study quantifies changes in soil organic carbon (SOC) stocks Belgium between 1960, 1990 and 2000 for 289 spatially explicit land units with unique association land-use type, termed landscape (LSU). SOC are derived from multiple nonstandardized sets of field measurements up to a depth 30 cm. Approximately half the LSU show an increase 1960 2000. significant increases occur mainly soils grassland northern Belgium. Significant decreases observed on loamy cropland soils. Although...
The potential involvement of actin and fodrin (brain spectrin) in secretory events has been assessed primary cultured guinea pig parotid acinar cells, using as a tool affinity purified anti-alpha-fodrin antibody, phalloidin, immunofluorescence techniques. In resting cells appeared continuous ring under the plasma membrane most cells. Upon stimulation with secretagogues labeling at level disappeared almost completely. To establish correlation between secretion cytoskeletal changes individual...
Inadequate remyelination of brain white matter lesions has been associated with a failure oligodendrocyte precursors to differentiate into mature, myelin-producing cells.In order better understand which genes play critical role in differentiation, we performed time-dependent, genomewide gene expression studies mouse Oli-neu cells as they process-forming and myelin basic protein-producing cells, following treatment three different agents.Our data indicate that inducers activate distinct...
PI3K delta (PI3Kδ) inhibitors are used to treat lymphomas but safety concerns and limited target selectivity curbed their clinical usefulness. PI3Kδ inhibition in solid tumors has recently emerged as a potential novel anticancer therapy through the modulation of T-cell responses direct antitumor activity. Here we report exploration IOA-244/MSC2360844, first-in-class non–ATP-competitive inhibitor, for treatment tumors. We confirm IOA-244’s tested against large set kinases, enzymes, receptors....
Kinases are key targets for drug discovery. In the field of screening in general and especially kinase area, because considerations efficiency cost, radioactivity-based assays tend to be replaced by alternative, mostly fluorescence-based, assays. Today, limiting factor is rarely number data points that can obtained but rather quality data, enzyme availability, cost. this article, authors describe development an assay a screen based on electrophoretic separation fluorescent product substrate...
Abstract: The membrane of chromaffin granule, the secretory vesicle adrenal medullary cells storing catecholamines, enkephalins, and many other components, interacts with F‐actin. Using low shear falling ball viscometry to estimate actin binding membranes, we demonstrated that mitochondrial plasma membranes from also provoked large increases in viscosity F‐actin solutions. Mitochondrial had capacity cause complete gelation In addition, vasopressin‐containing granules neurohypophysial tissue...
The metJ gene encoding the methionine aporepressor was placed under control of a strong and inducible promoter, ptac.Bacterial strains carrying recombinant plasmid pIP35 overproduced regulatory protein by factor 200 over wild type strain as determined immunoblot technique.The purified product negatively controls expression metF gene, in cell-free system shown repression ,%galactosidase synthesis promoter.The binds to DNA fragment containing potential operator with an affinity which is 10...