A5063343251- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- T-cell and B-cell Immunology
- Pharmacological Receptor Mechanisms and Effects
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Viral Infections and Outbreaks Research
- Hormonal Regulation and Hypertension
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Adverse Reactions
Jagiellonian University
2016-2025
Yale University
2015-2021
Hospital Universitario de La Princesa
2019-2021
Universidad Autónoma de Madrid
2019-2021
Collegium Medicum in Bydgoszcz
2015
In a previous report we showed that intravenous infusion of bone marrow-derived mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord injury (SCI) in the non-immunosuppressed rat, although MSCs themselves were not detected at site [1]. Rather, lodged transiently lungs for about two days post-infusion. Preliminary studies and recent [2] suggest effects (IV) could be mimicked by IV exosomes isolated from conditioned media MSC cultures (MSCexos). this study,...
Lymph node and spleen cells of mice doubly immunized by epicutaneous intravenous hapten application produce a suppressive component that inhibits the action effector T mediate contact sensitivity reactions. We recently re-investigated this phenomenon in an immunological system. CD8+ lymphocyte-derived exosomes transferred miR-150 to antigen-specifically due exosome surface coat antibody light chains made B1a lymphocytes. Extracellular RNA (exRNA) is protected from plasma RNases carriage or...
Summary Murine contact sensitivity ( CS ) reaction could be antigen‐specifically regulated by T CD 8 + suppressor (Ts) lymphocytes releasing micro RNA ‐150 in antibody light‐chain‐coated exosomes that were formerly suggested to suppress through action on macrophages (M φ ). The present studies investigated the role of M Ts cell‐exosome‐mediated antigen‐specific suppression as well modulation antigen‐presenting function humoral and cellular immunity suppressive exosomes. Mice depleted...
In patients with non-IgE-mediated milk allergy, a cellular mechanism of delayed-type hypersensitivity (DTH) is considered. Recent findings prove that cell-mediated reactions can be antigen-specifically inhibited by extracellular vesicles (EVs) carrying miRNA-150. We sought to establish new mouse model DTH casein and test the possibility antigen-specific suppression inflammatory reaction. To produce soluble antigenic peptides, was subjected alkaline hydrolysis. reaction induced in CBA,...
We previously discovered suppressor T cell-derived, antigen (Ag)-specific exosomes inhibiting mouse hapten-induced contact sensitivity effector cells by targeting antigen-presenting (APCs). These suppressive acted Ag-specifically due to a coating of antibody free light chains (FLC) from Ag-activated B1a cells. Current studies are aimed at determining if similar immune tolerance could be induced in cutaneous delayed-type hypersensitivity (DTH) the protein Ag (ovalbumin, OVA). Intravenous...
Depression is associated with an altered immune response, which could be normalized by antidepressant drugs. However, little known about the influence of antidepressants on peripheral response and function macrophages in individuals not suffering from depression. Our studies were aimed at determining drugs humoral cellular mice. Mice treated intraperitoneally imipramine, fluoxetine, venlafaxine, or moclobemide contact immunized trinitrophenyl hapten followed elicitation measurement...
Psoriasis is a systemic autoimmune/autoinflammatory disease that can be well studied in established mouse models. Skin-resident macrophages are classified into epidermal Langerhans cells and dermal involved innate immunity, orchestration of adaptive maintenance tissue homeostasis due to their ability constantly shift phenotype adapt the current microenvironment. Consequently, both macrophage populations play dual roles psoriasis. In some circumstances, pro-inflammatory activated trigger...
We describe a protective early acquired immune response to pneumococcal pneumonia that is mediated by subset of B1a cells. Mice deficient in B1 cells (xid), or activation-induced cytidine deaminase (AID(-/-) ), invariant natural killer T (iNKT) (Jα18(-/-) interleukin-13 (IL-13(-/-) ) had impaired clearance pneumococci the lung, compared with wild-type mice. In contrast, AID(-/-) mice adoptively transferred AID(+/+) cells, significantly cleared bacteria from lungs as 3 days post infection....