A5092051851- Immune responses and vaccinations
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cystic Fibrosis Research Advances
- Neuropeptides and Animal Physiology
Jagiellonian University
2023-2024
Lung cystic fibrosis (CF) is characterized by chronic infections and hyperinflammatory response of neutrophils macrophages. P. aeruginosa (PA) S. aureus (MSSA, MRSA) are major pathogens advanced CF. The main goal this study was to compare the inflammatory phenotype murine C57BL/6 macrophages exposed PA57 with that MSSA60, both strains isolated from same patient severe In present study, we used mice sensitive lung infection aeruginosa.We measured release cytokines expression phenotypic...
OBJECTIVE P. AERUGINOSA: (PA), the major pathogen of lung cystic fibrosis (CF), polarizes macrophages into hyperinflammatory tissue damaging phenotype. The main aim this study was to verify whether training with β-glucan might improve their response aeruginosa infections.
Among other functions, macrophages remove foreign particles, including medications, from the circulation, making them an important target for immunomodulatory molecules. Currently, growing evidence suggests that analgesics affect activity of immune cells not directly related to pain, and thus may induce unwanted immunosuppression in patients at risk. However, effects resulting macrophage targeting by these drugs are understudied. Therefore, current study investigated induced healthy mice...