A5080661827- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Quinazolinone synthesis and applications
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Catalytic C–H Functionalization Methods
- Surfactants and Colloidal Systems
- Cholinesterase and Neurodegenerative Diseases
- Sulfur-Based Synthesis Techniques
- HIV/AIDS drug development and treatment
- Carbohydrate Chemistry and Synthesis
- Metal complexes synthesis and properties
- Chemical synthesis and alkaloids
- Catalytic Cross-Coupling Reactions
- Cancer therapeutics and mechanisms
- Enzyme function and inhibition
- Click Chemistry and Applications
- Crystallography and molecular interactions
Government College University, Faisalabad
2016-2025
University of Faisalabad
2017-2020
Quaid-i-Azam University
2020
University of the Punjab
2007-2012
Pakistan Council of Scientific & Industrial Research
2009-2010
β-Amino alcohols are versatile intermediates in the synthesis of various biologically potent compounds, which can also be achieved by ring opening epoxides amines. In present review, focus has been placed on with amines under a variety reaction parameters reported during 2011–2015. All factors that resulted excellent yields and high regioselectivity, environmentally benign, use mild conditions have discussed detail. addition, applications these methods active compounds such as β-blockers described.
Middle East respiratory syndrome (MERS-COV), first identified in Saudi Arabia, was caused by a novel strain of coronavirus. Outbreaks were recorded from different regions the world, especially South Korea and East, correlated with 35% mortality rate. MERS-COV is single-stranded, positive RNA virus that reaches host binding to receptor dipeptidyl-peptides. Because unavailability vaccine available for protection infection, rapid case detection, isolation, infection prevention has been...
Diabetes mellitus (DM), a complicated metabolic disorder, is due to insensitivity insulin function or reduction in secretion, which results postprandial hyperglycemia. α-Glucosidase inhibitors (AGIs) and α-amylase (AAIs) block the of digestive enzymes, delays carbohydrate hydrolysis process ultimately helps control Diversified 2-(3-(3-methoxybenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides were synthesized evaluated for their vitro inhibitory potential against...
N-aryl pyrazoles are important building blocks in many biologically active compounds, natural products, pharmaceuticals, and industries. It is an moiety of various drugs exhibits extensive biological activities viz., antibiotic, anticancer, antifungal, anti-inflammatory, anti-coagulant, analgesic, antipyretic, anti-depressant, insecticidal, hyperglycemic activities. Various protocols have been designed for the synthesis facilitated by a wide variety metal-based catalysts at high or room...
Abstract: The Coronavirus disease 2019 (COVID-19) pandemic is one of the most considerable health problems across world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) major causative agent COVID-19. severe symptoms this deadly include shortness breath, fever, cough, loss smell, and a broad spectrum other issues such as diarrhea, pneumonia, bronchitis, septic shock, multiple organ failure. Currently, there are no medications available for patients, except symptom-relieving...
Tyrosine threonine kinase (TTK) is the key component of spindle assembly checkpoint (SAC) that ensures correct attachment chromosomes to mitotic and thereby their precise segregation into daughter cells by phosphorylating specific substrate proteins. The overexpression TTK has been associated with various human malignancies, including breast, colorectal thyroid carcinomas. validated as a target for drug development, several inhibitors have discovered. In this study, ligand structure-based...
The piperazine ring system is among the medicinally important nitrogen-containing heterocyclic systems and exploited for synthesis of various drug molecules. A number FDA-approved anticancer drugs contain rings thus it considered as an attractive scaffold having extraordinary potential development new agents. In recent decades there has been alarming increase in people suffering from cancerous diseases all over world, which resulted research reports on candidates. aim this article to...
Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes rise pH, supports the survival of pathogens, can lead to infections such as gastric disorders like ulcers cancer humans. Helicobacter pylori employs urease for acidic environment stomach protein synthesis. To treat inhibit growth it is mandatory obstruct activity; therefore, derivatives...