A5101590553- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Multiple and Secondary Primary Cancers
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alcohol Consumption and Health Effects
- Advanced Breast Cancer Therapies
- Dietary Effects on Health
- Coffee research and impacts
University of Calgary
2015-2025
Alberta Health Services
2014-2025
Alberta Health
2019
Centre international de recherche sur le cancer
2014-2015
Northwestern University
2014
Lunenfeld-Tanenbaum Research Institute
2011-2012
University of Toronto
2008-2011
Public Health Ontario
2011
Mount Sinai Hospital
2011
Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies investigated multiple simultaneously.
Abstract Background This study aimed to investigate whether waist circumference (WC) or body mass index (BMI) is a better predictor of blood lipid concentrations among young men and women from different ethnocultural groups. Methods Participants were 1181 healthy (n = 358) 823) aged 20-29 years taken the cross-sectional Toronto Nutrigenomics Health Study. Analyses conducted separately for women, Caucasian East Asian Serum triglycerides (TG) total HDL cholesterol ratio (TC:HDL cholesterol)...
Background: Western populations are losing the battle over healthy weight management, and excess body is a notable cancer risk factor at population level. There ongoing interest in pharmacological interventions aimed promoting loss, including GLP-1 receptor agonists (GLP-1RA), which may be useful tool to stem rising tide of obesity-related cancers. Purpose: To investigate potential next generation loss drugs (NGWLD) like GLP-1RA population-level chemoprevention. Research Design: We used...
Background Oxidative stress may contribute to cancer aetiology through several mechanisms involving damage DNA, proteins and lipids leading genetic mutations genomic instability. The objective of this study was determine the effects aerobic exercise on markers oxidative antioxidant enzymes in postmenopausal women. Methods Alberta Physical Activity Breast Cancer Prevention Trial (ALPHA) a two-centre, two-armed randomised trial 320 inactive, healthy, women aged 50–74 years. Participants were...
Introduction The United States of America reignited their Cancer Moonshot Initiative in 2022 with an ambitious goal to reduce cancer mortality by 50% over the next 25 years. In this study, we estimated how and whether a similar control initiative could be achieved Canada. Methods We used OncoSim microsimulation suite address three questions: (1) what is expected from Canada 2050 given current trends?; (2) would maximal impact on reducing prevention increased screening activities? and, (3) if...
Cell-free DNA (cfDNA) testing is an emerging approach for colorectal cancer screening that has been approved in the US. The impact of cfDNA Canadian setting, assuming adherence mirroring prior real-world work and assay performance from a Guardant Health study, unknown. To estimate how impacts clinical economic outcomes Canada compared with existing approaches (fecal immunochemical [FIT] or colonoscopies). OncoSim-Colorectal model (version 3.6.5.7) was used to simulate participation, relative...
This randomized dose comparison trial examined if higher exercise volume decreased inflammatory biomarkers, associated with postmenopausal breast cancer risk, more than moderate volume. The Breast Cancer and Exercise Trial in Alberta was a two-center, two-armed 400 inactive, healthy, women, aged 50 to 74 years, body mass index of 22 40 kg/m(2). Participants were high (300 minutes/week) or (150 volumes aerobic while maintaining usual diet. Fasting blood concentrations C-reactive protein...
Abstract The mechanisms whereby regular exercise reduces chronic inflammation remain unclear. We investigated whether aerobic alters basal levels of interleukin ( IL )‐10 and ‐4 in two randomized trials physical activity. Alberta Physical Activity Breast Cancer Prevention Trial ALPHA , n = 320) the Exercise BETA 400) were two‐center, two‐armed inactive, healthy, postmenopausal women. Both included an intervention prescribed five times/week no dietary changes. In group was 225 min/week versus...
Vascular endothelial growth factor (VEGF) and Fibroblast factor-2 (FGF2) are angiogenic cytokines in normal tissues tumors. Evidence suggests that increased expression adipose tissue leads to improved vascularity decreased hypoxia, fibrosis, inflammation, which may, turn, reduce post-menopausal breast cancer risk.We investigated whether or not exercise had dose-response effects on levels of plasma VEGF FGF2 postmenopausal women.Four hundred previously inactive but healthy women aged 50-74...
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also upper aerodigestive tract (UADT) cases (OR = 1.09, 95% CI: 1.04–1.15, p 6x10−4). We additionally identified rs10849605 as RAD52 cis-eQTL inUADT(p 1x10−3) LUSC (p 9x10−4) tumours, UADT/LUSC risk allele correlated increased expression...
Physical activity is associated with a lower risk of breast, colon, and endometrial cancer. Epigenetic mechanisms such as changes in DNA methylation may help to explain these protective effects. We assessed the impact one year aerobic exercise intervention on biomarkers believed play role carcinogenesis. The Alberta Activity Breast Cancer Prevention (ALPHA) Trial was two-armed randomized controlled trial 320 healthy, inactive, postmenopausal women no history In an ancillary analysis, frozen...
Abstract Background Laboratory data can provide great value to support research aimed at reducing the incidence, prolonging survival and enhancing outcomes of cancer. Data is characterized by information it carries format holds. captured in Alberta’s biomarker laboratory repository free text, cluttered rouge. Such limits its utility prohibits broader adoption development. Text analysis for extraction unstructured change this lead more complete analyses. Previous work on extracting relevant...
<sec> <title>Introduction</title> Moderate to heavy alcohol consumption is a risk factor for all-cause mortality and cancer incidence. Although cross-sectional data are available through national surveys, on in Alberta from large prospective cohort were not previously available. The goal of these analyses was characterize the levels among adults Alberta’s Tomorrow Project context prevention guidelines. Furthermore, we conducted examine relationships between other high-risk or risk-related...
Excess body weight during adulthood has been consistently associated with all-cause mortality, cardiovascular disease, and cancer at multiple sites among other chronic diseases. We describe the prevalence of excess abdominal obesity reported by participants enrolled in Alberta's Tomorrow Project (ATP).ATP is a geographically-based cohort study conducted adults aged 35-69 years from across province Alberta. Participants completed anthropometric measures health lifestyle questionnaires...
To quantify the resource use of revising breast cancer screening guidelines to include average-risk women aged 40-49 years across Canada from 2024 2043 using a validated microsimulation model.