Ioan Nicolae Mateș
A5086937257- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Genetic Associations and Epidemiology
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anorectal Disease Treatments and Outcomes
- Cancer Treatment and Pharmacology
- Microbial infections and disease research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Urological Disorders and Treatments
- Colorectal Cancer Surgical Treatments
- Stoma care and complications
- Gastrointestinal Tumor Research and Treatment
- Viral-associated cancers and disorders
Carol Davila University of Medicine and Pharmacy
2010-2025
Clinical Emergency Hospital Bucharest
2007-2025
Regional Health
2015
Universidade Federal de Pelotas
2013
Division of Cancer Epidemiology and Genetics
2009
National Cancer Institute
2008-2009
Spitalul Clinic de Urgenta Sfantul Ioan
2004
Spitalul Clinic Colentina
1997
Cigar and pipe smoking are considered risk factors for head neck cancers, but the magnitude of effect estimates these products has been imprecisely estimated. By using pooled data from International Head Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases 18,691 controls in 19 studies 1981 to 2007), we applied hierarchical logistic regression more precisely estimate odds ratios 95% confidence intervals cigarette, cigar, separately, compared with reference groups those who...
Conclusions Our results support that cessation of tobacco smoking and alcohol drinking protect against the development head neck cancer.
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in development cancer, authors conducted a pooled analysis studies International Lung Cancer Consortium. Seventeen including 24,607 cases 81,829 controls (noncases), mainly Europe North America, were included (1984–2011). Using self-reported data on diagnoses diseases, derived study-specific effect estimates by means logistic regression models or Cox proportional hazards adjusted for...
Although cigarette smoking and alcohol consumption increase risk for head neck cancers, there have been few attempts to model risks quantitatively formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies modeled the excess odds ratio (EOR) assess by total exposure (pack-years drink-years) its modification rate (cigarettes/day drinks/day). analysis included 1,761 laryngeal, 2,453 pharyngeal, 1,990 oral cavity 2,551 3,693 3,116 oval with over 8,000...
Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating variant, rs11571833 (K3326X), has been associated with a 2.5-fold lung squamous cell carcinoma but only modest 26% in cancer risk. We analyzed the association between SNP and upper aerodigestive tract (UADT) multivariable unconditional logistic regression adjusted by sex combinations study country for 5942 UADT case patients 8086 control from nine different studies. All statistical tests...
The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption beer, wine, liquor. In particular, they calculated different measures beverage separately for subjects who drank beer only (858 986 controls), liquor-only drinkers (499 527 wine-only (1,021 2,460 alcohol never (1,124 3,487 used as a common reference group. observed similar ethanol-standardized frequency beer-only (odds ratios...
Odds ratios for head and neck cancer increase with greater cigarette alcohol use lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head Neck Cancer Epidemiology Consortium, authors conducted a formal analysis of BMI as modifier smoking- alcohol-related effects. Analysis never current smokers included 6,333 cases, while drinkers consumers ≤10 drinks/day 8,452 cases. There were 8,000 or more controls, depending on analysis. all sites increased BMI,...
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). Here, we further explore how tobacco exposure contributes to development by mutational signature analysis 265 whole-genome sequenced HNC from eight countries. Six tobacco-associated signatures were detected, including some not previously reported. Differences in incidence between countries corresponded differences mutation burdens signatures, consistent dominant role causation. found burden...
Folate has been hypothesized to protect against aero-digestive cancers although the evidence is not yet conclusive due possible confounding by other dietary factors. Sequence variants in folate pathway were suggested be associated with plasma levels and are unlikely confounded lifestyle We therefore investigated effects of key genetic on risk their potential effect modification intake a multicenter study Central Europe. A total 2250 lung cases, 811 upper tract cases 2899 controls recruited...
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). We explore how tobacco exposure contributes to development by mutational signature analysis 265 whole-genome sequenced HNC samples from eight countries. Six tobacco-associated signatures were detected, including some not previously reported. Differences in incidence between countries corresponded differences mutation burdens signatures, consistent dominant role causation. found burden...
Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) association with cutaneous basal-cell carcinoma (BCC) linked to a germline SNP rs700635. Here, we show that rs700635[C] allele, which is associated increased risk BCC breast cancer, protective against prostate cancer [odds ratio (OR) = 0.91, P 1.0 × 10−6]. also failures correctly splice out tumours corresponding normal tissues. Investigation carriers revealed they human-specific...
High-risk α mucosal types of human papillomavirus (HPV) cause anogenital and oropharyngeal cancers, whereas β cutaneous HPV (e.g. HPV8) have been implicated in non-melanoma skin cancer. Although antibodies against the capsid protein L1 are considered as markers cumulative exposure, not all infected persons seroconvert. To identify common genetic variants that influence seroconversion, we performed a two-stage genome-wide association study. Genome-wide genotyping 316 015 single nucleotide...
Background Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible increase the power by incorporating complementary data. In this study we investigated feasibility of automatically retrieving information from medical literature and leveraging in GWAS. Methods We developed a method that searches through PubMed abstracts for pre-assigned keywords key concepts, uses assign prior probabilities each single nucleotide...
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also upper aerodigestive tract (UADT) cases (OR = 1.09, 95% CI: 1.04–1.15, p 6x10−4). We additionally identified rs10849605 as RAD52 cis-eQTL inUADT(p 1x10−3) LUSC (p 9x10−4) tumours, UADT/LUSC risk allele correlated increased expression...
High-risk mucosal types of human papillomavirus (HPV) cause anogenital and oropharyngeal cancers, whereas cutaneous (e.g. HPV8 77) are suspected to be involved in non-melanoma skin cancer. The antibody response HPVs is a key determinant protective immunity, but not all infected individuals seroconvert. Genetic variability the host may have large impact on seroconversion. A previous genome-wide association study (GWAS) has identified susceptibility locus (rs41270488) for seropositivity within...
Abstract Prostate cancer is the third‐most common form of in men Romania. The Romanian unscreened population represents a good sample to study genetic risk variants. However, comprehensive analysis has not been conducted yet. Here, we report our replication efforts 979 cases and 1027 controls, for potential association 34 literature‐reported single nucleotide polymorphisms ( SNP s) with prostate cancer. We also examined whether any was differentially associated tumour grade or stage at...
The aim of this retrospective, observational, descriptive study was to identify predictors response neoadjuvant therapy in breast cancer patients and validate them using three anatomopathological scores, such as residual burden (RCB) score, Chevallier system, tumor-infiltrating lymphocytes (TIL) score.
Abstract Two familial forms of colorectal cancer ( CRC ), Lynch syndrome LS ) and adenomatous polyposis FAP are caused by rare mutations in DNA mismatch repair genes MLH 1 , MSH 2 6 PMS the APC MUTYH respectively. No information is available on presence high‐risk Romanian population. We performed whole‐genome sequencing 61 cases with a family history and/or early onset disease, focusing analysis candidate variants genes. The frequencies all were assessed cohort 688 4567 controls....
Alterations in global DNA methylation have been suggested to play an important role cancer development. We evaluated the association of peripheral blood with risk lung nonsmoking women from six countries Central and Eastern Europe. This multicenter case-control study included primary, incident cases diagnosed 1998 2001 controls frequency-matched for geographic area, sex, age. Global was assessed 83 female 181 using luminometric assay (LUMA). Unconditional logistic regression models were used...