A5089699608- Gut microbiota and health
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- T-cell and B-cell Immunology
- Infant Nutrition and Health
- Diabetes and associated disorders
- Birth, Development, and Health
- Antimicrobial Peptides and Activities
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Reproductive tract infections research
- Hereditary Neurological Disorders
- Advanced MEMS and NEMS Technologies
- Immunotherapy and Immune Responses
- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Dietary Effects on Health
- Reproductive System and Pregnancy
- Advanced Materials and Mechanics
- HIV Research and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Avian ecology and behavior
- Escherichia coli research studies
- Galectins and Cancer Biology
- Pluripotent Stem Cells Research
Chinese Academy of Forestry
2020-2023
University of Florida
2015-2023
Institute of Wetland Research
2020-2023
Tsinghua University
2023
Institute of Forest Ecology, Environment and Protection
2023
Jackson Laboratory
2022
Office of Infectious Diseases
2017
Ocean University of China
2014
Emerging evidence suggests that gut microbiota is critical in the maintenance of physiological homeostasis. This study was designed to test hypothesis dysbiosis associated with hypertension because genetic, environmental, and dietary factors profoundly influence both blood pressure. Bacterial DNA from fecal samples 2 rat models a small cohort patients used for bacterial genomic analysis. We observed significant decrease microbial richness, diversity, evenness spontaneously hypertensive rat,...
Gut microbiota dysbiosis induces lupus-like autoimmunity in mice through altered tryptophan catabolism.
Consumption of human breast milk (HBM) attenuates the incidence necrotizing enterocolitis (NEC), which remains a leading and intractable cause mortality in preterm infants. Here, we report that this diminution correlates with alterations gut microbiota, particularly enrichment Propionibacterium species. Transfaunation microbiota from HBM-fed infants or newly identified cultured strain, P. UF1, to germfree mice conferred protection against pathogen infection correlated profound increases...
Gut microbiota plays an important role for bird biological and ecological properties, sex diet may be intrinsic extrinsic fators influencing gut microbial communities. However, difference of has been rarely investigated in free-living birds, it remains unclear how interactively affect avian compostion diversity, particularly under natural conditions. Here we used non-invasive molecular sexing technique to the fecal samples collected from two wintering sites Great Bustard, which is most...
BackgroundMalaria infection in pregnancy is a major cause of maternal and foetal morbidity mortality worldwide. Mouse models for gestational malaria allow the exploration mechanisms linking poor outcomes tractable model system. The composition gut microbiota has been shown to influence susceptibility inbred virgin mice. In this study, we explore ability modulate severity pregnant outbred Swiss Webster mice.MethodsIn mice, was altered by disrupting native microbes through broad-spectrum...
Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. deficiency impaired the maintenance and function of Tregs, leading to global activation autoimmunity in aged mice. Further, Esrrg-deficient presented an differentiation into follicular enhanced helper cells' responses. Mechanistically, dysregulated decreased oxygen consumption as well ATP NAD+ production. In...
The expansion of follicular helper T (Tfh) cells, which is tightly associated with the development lupus, reversed by inhibition either glycolysis or glutaminolysis in mice. Here we analyzed gene expression and metabolome Tfh cells naive CD4+ (Tn) B6.Sle1.Sle2.Sle3 (triple congenic, TC) mouse model lupus its congenic B6 control. Lupus genetic susceptibility TC mice drives a signature starting Tn expanding enhanced signaling effector programs. Metabolically, showed multiple defective...
Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability P. UF1 bacterium derived from intestinal bacterial commensals preterm infants fed human breast milk significantly mitigate pathogen-induced inflammation limiting colonic Here we further elucidated potential also regulate innate T cells, particularly systemic L. m infection. Data...
In this paper, an angular position sensor (APS) designed for a resonant miniaturized scanning mirror (M-SM) is presented. The APS operates based on the principle of differential variable capacitance, significantly expanding detectable bandwidth from few hertz to several kilohertz. By modeling motion characteristics, sampling rates biaxial angles are 1473.6 times and 539.4 higher than those conventional sensors. Initially, characteristics model presented as simple harmonic motion, converting...
Patterns of movement through time are important components animal behavior and key to understanding ecology. Due methodological challenges, including tracing analyzing movements their changes, they seldom studied identify both seasonal patterns driving forces. Using seven GPS-collared red-crowned cranes (Grus japonensis, RCCs), we recorded moving distances concurrent climatic data analyze the relative importance these factors in RCC movements. Temperature was identified as most variables...
Abstract The gut microbiota is the most complex and abundant symbiotic microbial ecosystem in animals. Aging one of main factors that cause structure changes, relationship between age giant panda has been a key focus attention. specialized diet bamboo, it relies on colonizes its to complete digestion. However, there no in-depth understanding changes across lifespan pandas. Here, we identified differences four groups (cubs, juveniles, adults, geriatrics) using 16S rRNA gene high-throughput...
Abstract The gut microbiota is the most complex and abundant symbiotic microbial ecosystem in animals. Aging one of main factors that cause structure changes, relationship between age giant panda has been a key focus attention. specialized diet bamboo, it relies on colonizes its to complete digestion. However, there no in-depth understanding changes across lifespan pandas. Here, we identified differences four groups (cubs, juveniles, adults, geriatrics) using 16S rRNA gene high-throughput...
Abstract Background: T follicular helper CD4+ cells (Tfh) are essential for maintenance of systemic lupus erythematosus (SLE) as they help germinal center B generate high affinity auto-antibodies. The activation STAT3 is critical generation Tfh it promotes the transcription BCL6 (the factor cell differentiation). It recognized that activated, proliferating SLE cells, contain more iron than controls. Iron binds CDK1 to accentuate JAK1 phosphorylation and in cells. Whether increased content...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive follicular helper T (Tfh) cells license high-affinity autoantibody production. Strikingly, the frequency of circulating Tfh correlated with activity SLE patients. As such, understanding molecular mechanisms responsible for aberrant cell generation and activation fundamental significance. We previously demonstrated that expanded B6.Sle1.Sle2.Sle3 (TC triple congenic) model exhibit high glycolysis...