A5090905993- Neurogenesis and neuroplasticity mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Hydrocarbon exploration and reservoir analysis
- Hydraulic Fracturing and Reservoir Analysis
- Circadian rhythm and melatonin
- Drilling and Well Engineering
- Vascular Malformations Diagnosis and Treatment
- Folate and B Vitamins Research
- RNA modifications and cancer
- Respiratory and Cough-Related Research
- Immune cells in cancer
- Asthma and respiratory diseases
- Reservoir Engineering and Simulation Methods
- Neuroscience and Neural Engineering
- Cholesterol and Lipid Metabolism
- Spaceflight effects on biology
- 3D Printing in Biomedical Research
- Biochemical effects in animals
- Protein Tyrosine Phosphatases
- Cytokine Signaling Pathways and Interactions
- Neuroscience of respiration and sleep
- Glioma Diagnosis and Treatment
- Lipid metabolism and biosynthesis
University of California, San Francisco
2023-2024
Duke Medical Center
2016-2021
Duke University Hospital
2016-2021
Walter and Eliza Hall Institute of Medical Research
2021
Duke University
2016-2020
University of Calgary
2008
Abstract Developmental myelination is a protracted process in the mammalian brain 1 . One theory for why oligodendrocytes mature so slowly posits that may stabilize neuronal circuits and temper plasticity as animals age 2–4 We tested this visual cortex, which has well-defined critical period experience-dependent 5 During adolescence, experience modulated rate of oligodendrocyte maturation cortex. To determine whether turn regulates plasticity, we genetically blocked differentiation...
Influenza A virus (IAV) is rapidly detected in the airways by immune system, with resident parenchymal cells and leukocytes orchestrating viral sensing induction of antiviral inflammatory responses. The are innervated heterogeneous populations vagal sensory neurons which also play an important role pulmonary defense. How these respond to IAV respiratory infection remains unclear. Here, we use a murine model provide first evidence that undergo significant transcriptional changes following...
Axon specification is a critical step in neuronal development, and the function of glial cells this process not fully understood. Here, we show that C. elegans GLR regulate axon their nearby GABAergic RME neurons through GLR-RME gap junctions. Disruption junctions causes misaccumulation axonal markers non-axonal neurites converts microtubules those to form an axon-like assembly. We further uncover activation CDK-5 pathway calcium-dependent manner, involving calpain clp-4. Therefore, our...
The regulation of gliogenesis is a fundamental process for nervous system development, as the appropriate glial number and identity required functional system. To investigate molecular mechanisms involved in gliogenesis, we used C. elegans model identified function proneural gene lin-32/Atoh1 gliogenesis. We found that lin-32 functions during embryonic development to negatively regulate AMsh glia. ectopic cells at least partially arise from originally fated become CEPsh glia, suggesting...
Vitamin B12 is known to play critical roles during the development and aging of brain, vitamin deficiency has been linked neurodevelopmental degenerative disorders. However, underlying molecular mechanisms how affects maintenance nervous system are still unclear. Here, we report that can regulate glial migration synapse formation through control isoform-specific expression PTP-3/LAR PRTP (leukocyte-common antigen-related receptor-type tyrosine-protein phosphatase). We found uptake...
Coordination of cell growth is essential for the development brain, but molecular mechanisms underlying regulation glial and neuronal size are poorly understood. To investigate involved in regulation, we used Caenorhabditis elegans amphid sheath (AMsh) glia as a model show that conserved cis -Golgi membrane protein eas-1/GOLT1B negatively regulates growth. We found eas-1 inhibits E3 ubiquitin ligase rnf-145 /RNF145, which, turn, promotes nuclear activation sbp-1/ SREBP, key regulator sterol...
Heavy oil reservoirs are an abundant hydrocarbon resource, which will in all probability comprise a significant portion of long-term world production. The world's heavy reserves have been estimated to be about 6 trillion barrels—roughly equivalent conventional reserves. largest Canada, Venezuela, the United States, Norway, Indonesia, China, Russia, and Kuwait.
ABSTRACT BACKGROUND Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that may stabilize neuronal circuits and temper plasticity as animals age. We tested this hypothesis visual cortex, which has well-defined critical period experience-dependent plasticity. OBJECTIVES/METHODS To prevent myelin progression, we conditionally deleted Myrf, transcription factor necessary oligodendrocyte maturation, from precursor...
As one of the most-studied receptors, Robo plays functions in many biological processes, and its highly depend on Slit, ligand Robo. Here we uncover a Slit-independent role glial migration show that neurons can release an extracellular fragment upon cleavage to attract glia during Caenorhabditis elegans . Furthermore, identified conserved cell adhesion molecule SYG-1/Neph as receptor for cleaved mediate through regulation WAVE complex. Our studies reveal previously unknown function...