Taxane-based chemotherapy drugs (cabazitaxel, docetaxel, and paclitaxel) are microtubule inhibitors, which effectively frequently used to treat metastatic prostate cancer (PCa). Among these, cabazitaxel is offered as a new therapeutic option for patients with castration-resistant PC that resistant other taxanes. Here, we investigated the cellular molecular changes in response comparison docetaxel paclitaxel androgen-independent human PCas. The PCa cell lines, PC3 DU145, were treated 1 5nM...

Robot manipulators are robotic systems that frequently used in automation and able to provide increased speed, precision efficiency the industrial applications. Due their nonlinear complex nature, it is crucial optimize robot manipulator terms of trajectory control. In this study, positioning analysis based on artificial neural networks (ANN) were performed for textile industry optimal ANN model high-accuracy was improved. The inverse kinematic a 6 degree freedom (DOF) denim carried out via...

To investigate the effects of castration and testosterone on constricting effect phenylephrine endothelium-dependent -independent relaxing different agonists in corpus cavernosum male rabbits.Twenty rabbits were castrated 10 received replacement for 1 month after castration; further underwent a sham operation acted as controls. One killed their penises excised. Strips used isometric tension measurements organ chambers; concentration-response relationships phenylephrine, carbachol, adenosine...

Abstract Background Potential targets for prostate cancer therapy are urgently needed curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. However, the molecular effects CsA is not fully understood in cancer. In this research, we sought to determine role mechanism Materials methods PC3 DU145 cells were treated with time (12, 24, 48 h) dose dependent (2.5, 10, 25 μM) cell survival, migration, colony...

Pancuronium, vecuronium, rocuronium, and mivacurium are nondepolarizing neuromuscular blocking agents that affect the cardiovascular system with different potencies. Their effects clinically significant in anesthetic management of patients, particularly those undergoing cardiac surgery.We aimed to compare these compounds, such as heart rate developed force, one species under identical experimental conditions isolated rat atria.The left or right atria rats were removed suspended organ baths....

Objective To investigate the changes in corporal reactivity to adenosine and prostaglandin E 1 (PGE ) corpus cavernosal strips from alloxan‐induced diabetic rabbits determine effects of insulin therapy. Materials methods Twenty‐four New Zealand white were studied three equal groups: group 1, control; 2, diabetes induced by administration alloxan hydrochloride intravenously; 3, as 2 but with administered after induction diabetes. At end 8 weeks, animals was assessed organ chambers. Results...

To determine whether chronic renal failure (CRF) reduces nitrergic relaxant responses in a rabbit model.Ten rabbits underwent surgery to induce uraemia (CRF rabbits) and further 10 sham operation (controls). Corpus cavernosal tissue was prepared used organ-chamber experiments, with relaxation assessed against background of pre-contraction phenylephrine. At the plateau contraction, cumulative concentrations carbachol or sodium nitroprusside (SNP), test endothelium-dependent -independent...

Objective To examine purinergic relaxation responses in chronic renal failure (CRF) an experimental rabbit model, and thus evaluate the possible involvement of system erectile dysfunction with CRF. Materials methods The relaxant effects ATP were measured strips corpus cavernosum smooth muscle taken from control CRF rabbits. was induced New Zealand white rabbits as previously described. Penises excised 4 weeks after inducing uraemia. In organ bath controls pre‐contracted phenylephrine...

OBJECTIVES To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro , as intracavernosal injection adrenomedullin induces penile erection anaesthetized cat. MATERIALS AND METHODS The were investigated strips New Zealand rabbit cavernosum pre‐contracted with phenylephrine alone, presence indomethacin (cyclooxygenase inhibitor), Nω‐nitro l ‐arginine methyl...

Background: The incidence of hormonal dysfunction as a cause impotence remains controversial. However, several recent studies have reported evidence abnormalities in 25–35% impotent men. Hypothyroidism has been to occur 6% Methods: In the present study, we examined nitrergic responses hypothyroidism rabbit corpus cavernosum and compared them with controls. Results: Carbachol‐induced relaxation electrical field stimulation (EFS)‐induced frequency‐dependent relaxations decreased significantly...

Bu çalışma yonca ekiliş alanlarında sorun olan küçük tohumlu küskütü (Cuscuta approximata Bab.)’nün Van’daki yoğunluğu ve dağılımını saptamak amacıyla yapılmıştır. Araştırma 2009 2010 yıllarında, iklim diğer bazı özelliklerine göre ayrılan beş bölgesinde (Gürpınar, Muradiye–Çaldıran, Van Merkez–Edremit–Gevaş, Erciş Özalp–Saray) alanlarından her iki yılda 500’er örnek alınarak yürütülmüştür. Çalışmanın yürütüldüğü ilk yılda, birinci biçim öncesinde küskütle bulaşık yoncanın metrekarede...

In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary is first choice of arterial graft, second radial (RA). Unfortunately, RA spasms are a significant problem for surgical team to overcome in perioperative postoperative period. current practice, use vasodilator agents perioperatively pending graft preparation generally accepted these may be implemented topically, endoluminally or ways. Moxonidine latest second-generation, centrally acting...

Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and decreased nitric oxide bioactivity in cavernosal tissue. The role of on function is well known. Statins have lipid lowering properties can modulate endothelial bioavailability. Sildenafil, enhances smooth muscle relaxation corpus cavernosum. We investigated in-vitro effects sildenafil rosuvastatin nonadrenergic, non-cholinergic mediated metabolic syndrome rabbits, since alterations this pathway are...