A method for the direct functionalization of diamondoids has been developed using photoredox and H atom transfer catalysis. This C–H alkylation reaction excellent chemoselectivity strong 3° bonds adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal selectivity is observed new H-atom catalyst reported here comparison to five known photochemical systems. Derivatization broad scope adamantane-containing drugs highlights versatility functional group tolerance...

Abstract Carboxylic acids are among the most used feedstock chemicals due to their great structural diversity and easy handling. The use of carboxylic derivatives in decarboxylative couplings has proven be a valuable tool for construction C−C C‐heteroatom bonds. This synthetic strategy provides complementary bond disconnection traditional cross‐coupling methods. In this review, we provide comprehensive overview decarboxylation‐initiated intermolecular formation, outlining several main...

An iterative cross-coupling approach to conjugated trienes was explored as part of a planned stereoselective synthesis bicyclic terpenes. Using bifunctional bromoboronate building block, sequential Suzuki coupling reactions were employed provide trienone target containing tetrasubstituted alkene. During the final step, an unexpected alkene isomerization observed give less hindered trans products. Examination different substrates determined that conjugation ketone withdrawing group...

Malylglutamate, a newly identified metabolite in earthworms, was synthesized using traditional peptide coupling approach for assembling the amide from protected malate and glutamate precursors. The proposed structure (1) diastereomer were synthesized, but their NMR spectra did not match natural sample. Further analysis of sample HMBC spectroscopy suggested an alternative attachment malyl moiety, β-malylglutamate (2) diastereomers L,L-2 D,D-2. excellent with sample, chiral-phase...

A new method for the direct functionalization of diamondoids has been developed using photoredox and H-atom transfer catalysis. This C–H alkylation reaction excellent chemoselectivity strong 3º bonds adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal selectivity is observed catalyst reported here when compared to six known photochemical systems. Derivatization broad scope adamantane-containing drugs highlights versatility functional group tolerance this strategy.

A new method for the direct functionalization of diamondoids has been developed using photoredox and H-atom transfer catalysis. This C–H alkylation reaction excellent chemoselectivity strong 3º bonds adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal selectivity is observed catalyst reported here when compared to six known photochemical systems. Derivatization broad scope adamantane-containing drugs highlights versatility functional group tolerance this strategy.

<p>A new method for the direct functionalization of diamondoids has been developed using photoredox and H-atom transfer catalysis. This C–H alkylation reaction excellent chemoselectivity strong 3º bonds adamantanes in polyfunctional molecules. In substrate competition reactions, a reversal selectivity is observed catalyst reported here when compared to six known photochemical systems. Derivatization broad scope adamantane-containing drugs highlights versatility functional group...