A5052086060- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Congenital heart defects research
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Ubiquitin and proteasome pathways
- Zebrafish Biomedical Research Applications
- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Developmental Biology and Gene Regulation
- S100 Proteins and Annexins
- Muscle Physiology and Disorders
- Hypothalamic control of reproductive hormones
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
University of Helsinki
2015-2020
University of Tartu
2015
Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic hindbrain serotonergic pathways controlling motivation, mood, voluntary movements. Such reside both within the nuclei, in adjacent brain structures, including rostromedial laterodorsal tegmental nuclei. Compared to monoaminergic neurons, development, heterogeneity, molecular characteristics of these regulatory poorly understood. We show here that different subgroups associated with nuclei...
Serotonergic and glutamatergic neurons of the dorsal raphe regulate many brain functions are important for mental health. Their functional diversity is based on molecularly distinct subtypes; however, development this heterogeneity poorly understood. We show that ventral neuroepithelium mouse anterior hindbrain divided into specific subdomains giving rise to serotonergic as well other types glia. The newly born precursors segregated subpopulations expressing vesicular glutamate transporter 3...
Tegmental nuclei in the ventral midbrain and anterior hindbrain control motivated behavior, mood, memory, movement. These contain inhibitory GABAergic excitatory glutamatergic neurons, whose molecular diversity development remain largely unraveled. Many tegmental neurons originate embryonic rhombomere 1 (r1), where fate is regulated by transcription factor (TF) Tal1. We used single-cell mRNA sequencing of mouse r1 to characterize Tal1-dependent independent neuronal precursors. describe gene...
Serotonergic neurons in the dorsal raphe (DR) nucleus are associated with several psychiatric disorders including depression and anxiety disorders, which often have a neurodevelopmental component. During embryonic development, GATA transcription factors GATA2 GATA3 operate as serotonergic neuron fate selectors regulate differentiation of subtypes DR. Here, we analyzed requirement cofactor ZFPM1 development using Zfpm1 conditional mouse mutants. Our results demonstrated that, unlike factors,...
ABSTRACT RIC8A is a noncanonical guanine nucleotide exchange factor for subset of Gα subunits. has been reported in different model organisms to participate the control mitotic cell division, signalling, development and migration. Still, function mammalian nervous system not sufficiently analysed yet. Adult mice express brain regions involved regulation memory emotional behaviour. To elucidate role neurogenesis we have inactivated Ric8a neural precursor cells using Cre/Lox system. As result,...
ABSTRACT Autosomal recessive disorders such as Fukuyama congenital muscular dystrophy, Walker–Warburg syndrome, and the muscle–eye–brain disease are characterized by defects in development of patient's brain, eyes, skeletal muscles. These syndromes accompanied brain malformations like type II lissencephaly cerebral cortex with characteristic overmigrations neurons through breaches pial basement membrane. The signaling pathways activated laminin receptors, dystroglycan integrins, control...