A5027621062- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Pharmacological Effects and Assays
- Memory and Neural Mechanisms
- Pancreatic function and diabetes
- Congenital heart defects research
- Cell Adhesion Molecules Research
- Attention Deficit Hyperactivity Disorder
- Single-cell and spatial transcriptomics
- Bone and Dental Protein Studies
- Cardiovascular and exercise physiology
- Advanced Glycation End Products research
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
Sapienza University of Rome
2015-2020
University of Helsinki
2015-2020
University Medical Center Utrecht
2012-2015
Utrecht University
2012
University of Turin
2008
Abstract A variety of environmental agents has been found to influence the development autoimmune diseases; in particular, studies investigating potential association systemic rheumatic diseases with micro and nano-particulate matter are very few contradictory. In this study, role diesel exhaust particles (DEPs), one most important components environment particulate matter, emitted from Euro 4 5 engines altering Normal Human Bronchial Epithelial (NHBE) cell biological activity was evaluated....
In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1 (GnRH-1). These cells originate during embryonic development in olfactory placode and migrate into forebrain, where they become integral members of hypothalamic–pituitary–gonadal axis. This migratory process regulated by a wide range guidance cues, which allow GnRH-1 to travel over long distances reach their appropriate destinations. The Semaphorin4D (Sema4D)...
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective study was to evaluate prevalence, sensitivity and specificity anti-CarP compared anti-citrullinated peptide antibodies (ACPA) factor (RF), replicating existing data a large cohort Italian RA extending evaluation other autoimmune rheumatic diseases (AIRDs). Serum samples (n = 607) from 309 RA, 200 disease controls 98 normal healthy subjects...
The striatum is a large brain nucleus with an important role in the control of movement and emotions. Medium spiny neurons (MSNs) are striatal output forming prominent descending axon tracts that target different nuclei. However, how MSN forebrain develop remains poorly understood. Here, we implicate Wnt binding receptor Frizzled3 several uncharacterized aspects pathway formation [i.e., anterior–posterior guidance axons their subsequent growth into globus pallidus (GP), (intermediate)...
Abstract Background Circulating endothelial progenitor cells (EPCs) are biologic markers of function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment EPCs contribute to dysfunction. Through ex vivo in vitro studies, we aimed at evaluating effects B lymphocyte stimulator (BLyS) on EPC colonies also investigating BLyS receptor expression these cells. Methods were isolated from peripheral blood mononuclear (PBMC). order evaluate their...
Tegmental nuclei in the ventral midbrain and anterior hindbrain control motivated behavior, mood, memory, movement. These contain inhibitory GABAergic excitatory glutamatergic neurons, whose molecular diversity development remain largely unraveled. Many tegmental neurons originate embryonic rhombomere 1 (r1), where fate is regulated by transcription factor (TF) Tal1. We used single-cell mRNA sequencing of mouse r1 to characterize Tal1-dependent independent neuronal precursors. describe gene...
Abstract The neural circuits regulating motivation and movement include midbrain dopaminergic neurons associated inhibitory GABAergic excitatory glutamatergic in the anterior brainstem. Differentiation of specific subtypes mouse embryonic brainstem is controlled by a transcription factor Tal1 . This study characterizes behavioral neurochemical changes caused absence function. cko mutant mice are hyperactive, impulsive, hypersensitive to reward, have learning deficits habituation defect novel...
The aim of this study was to analyze the effects chronic administration β 2 -agonist clenbuterol (1.5 mg · kg −1 day for 4 wk in drinking water) on respiratory (diaphragm and parasternal intercostal) hindlimb (tibialis soleus) muscles young rats during postnatal development (21 49 days). treatment resulted very little stimulation muscle growth. Significant slow-to-fast transitions expression myosin heavy chain isoforms significant increases myofibrillar ATPase activity were found diaphragm...
Midbrain dopamine (mdDA) neurons project via the medial forebrain bundle towards several areas in telencephalon, including striatum1. Reciprocally, medium spiny striatum that give rise to striatonigral (direct) pathway innervate substantia nigra2. The development of these axon tracts is dependent upon combinatorial actions a plethora growth and guidance cues molecules are released by neurites or (intermediate) target regions3,4. These soluble factors can be studied vitro culturing mdDA...
Patients treated with the TNF antagonist adalimumab develop anti-therapeutic antibodies (ATA), prevalence of which varies depending on assay used. Most assays are compromised due to presence in clinical samples. Our objective was an antibody assay, applicable for testing, overcomes limitation therapeutic interference and further determine relationship between ATA development, levels disease activity patients rheumatoid arthritis (RA), psoriatic (PsA) or ankylosing spondylitis (AS). Use...
<h3>Background</h3> Circulating endothelial progenitor cells (EPCs) are bone marrow-derived able to differentiate into mature cells; impairment of number and function these is associated with increased subclinical atherosclerosis. Cardiovascular risk highly in patients Systemic Lupus Erythematosus (SLE). Several studies demonstrated that EPCs reduced impaired SLE patients, partially accounting for the dysfunction characterizing patients. In murine models, inhibition B Lymphocyte Stimulator...
<h3>Objectives</h3> To investigate the prevalence of anti-carbamylated protein antibodies (anti-CarP) in Healthy first-degree relatives (HFDRs) patients with Rheumatoid Arthritis (RA). <h3>Methods</h3> We enrolled 141 HFDRs 63 RA diagnosed accordingly to 2010 ACR/EULAR criteria. Fifty-six normal healthy subjects (NHS), sex and age matched, served as controls. Anti-CarP IgG, anti-cyclic citrullinated peptide antibody (anti-CCP) IgG rheumatoid factors (RF) isotypes (IgG, IgA, IgM) were...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE)is a chronic disease requiring long-term treatment. Even though immunosuppresive therapies improved the survival rate,a great percentage of SLE patients exhibit persistently active disease, or flares. Belimumab (BLM), is currently only biological drug approved for treatment not responding to standard care, without kidney neuropsychiatric (NP)involvement. <h3>Objectives</h3> Aim study was analyse 36 months BLM treatment, causes withdrawal...
<h3>Background</h3> The anti-CD20 monoclonal antibody rituximab (RTX) is an effective treatment option for patients with systemic lupus erythematosus (SLE) refractory to conventional therapies. safety of this drug has been widely analyzed in randomized controlled clinical trials rheumatoid arthritis (RA); on the contrary, there are few data SLE. <h3>Objectives</h3> We aimed evaluate and survival RTX SLE RA a 10 years observational study. <h3>Methods</h3> evaluated history laboratory (1997...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by periods of remission and flares. Recently, a monoclonal anti-BLyS (<i>B Lymphocyte Stimulator</i>) antibody, Belimumab, has been approved for the treatment SLE patients with active refractory to conventional therapy. The evaluation Quality Life (QoL) critical issue in global assessment patients, considering possible influence work ability. LupusQoL questionnaire, specifically designed validated....
<h3>Background</h3> The achievement of complete remission is one the most important goal in management patients with Systemic Lupus Erythematosus (SLE). Even though a definition has been proposed (complete absence any clinical and serological sign or symptom activity) concomitant acceptable treatment (including antimalarial drugs only) identified, however minimum lapse time still controversial. This issue primary importance disease characterized by relapsing-remitting course. Several cut-off...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is a chronic disease requiring long-term treatment. Even though immunosuppresive therapy has significantly improved the survival, great percentage of SLE patients exhibit persistently active or deal with flares during follow-up. Belimumab (BLM), an anti-<i>B Lymphocyte Stimulator</i> (BLyS), currently only biological drug approved for treatment not responding to standard care, without kidney neuropsychiatric involvement....
Midbrain dopamine (mdDA) neurons project via the medial forebrain bundle towards several areas in telencephalon, including striatum1. Reciprocally, medium spiny striatum that give rise to striatonigral (direct) pathway innervate substantia nigra2. The development of these axon tracts is dependent upon combinatorial actions a plethora growth and guidance cues molecules are released by neurites or (intermediate) target regions3,4. These soluble factors can be studied vitro culturing mdDA...
<h3>Background</h3> Circulating endothelial progenitor cells (EPCs) are surrogate markers of function. Several studies demonstrated a reduction and functional impairment EPCs in patients with Systemic Lupus Erythematosus (SLE), partially accounting for dysfunction. In murine models atherosclerosis, treatment B Lymphocyte Stimulator (BLyS) inhibitor slowed the progression reduced size atherosclerotic plaque. Belimumab (BLM) is human anti-BLyS monoclonal antibody approved SLE....
<h3>Background</h3> Belimumab (BLM), a fully human monoclonal antibody directed against B lymphocyte stimulator (BLyS), is currently the only biological drug approved for treatment of active Systemic Lupus erythematosus (SLE) patients not responding to standard care. Data from RCTs and observational studies have demonstrated its efficacy, especially in with joint involvement. Focusing on this specific manifestation, response has been also by using Disease Activity Score 28 joints (DAS28)...