A5087114633- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Neuropeptides and Animal Physiology
- Vestibular and auditory disorders
- Genetic Associations and Epidemiology
- Neurogenetic and Muscular Disorders Research
- Ion Channels and Receptors
- Migraine and Headache Studies
- Schizophrenia research and treatment
- Diabetes and associated disorders
- Viral Infections and Immunology Research
- Dermatology and Skin Diseases
- Nuclear Receptors and Signaling
- RNA Research and Splicing
Dublin City University
2019-2023
Petersburg Nuclear Physics Institute
2019-2020
Kurchatov Institute
2019-2020
The trafficking of transient receptor potential (TRP) channels to the plasma membrane and release calcitonin gene-related peptide (CGRP) from trigeminal ganglion neurons (TGNs) are implicated in some aspects chronic migraines. These exocytotic processes inhibited by cleavage SNAREs with botulinum neurotoxins (BoNTs); moreover, type A toxin (/A) clinically reduces frequency severity migraine attacks but not all patients for unknown reasons. Herein, neonatal rat TGNs were stimulated allyl...
Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neurons from neonatal rat trigeminal ganglia-a locus craniofacial sensory nerves-were used examine how NGF affects Ca2+-dependent release of a mediator, calcitonin gene-related peptide (CGRP), that triggered by activating key signal transducer,...
Chimeras of botulinum neurotoxin (BoNT) serotype A (/A) combined with /E protease might possess improved analgesic properties relative to either parent, due inheriting the sensory neurotropism former more extensive disabling SNAP-25 from latter. Hence, fusions light chain (LC) whole BoNT/A (LC/E-BoNT/A), and LC plus translocation domain (HN) neuronal acceptor binding moiety (HC) /A (BoNT/EA), created previously by gene recombination expression in E. coli., were used. LC/E-BoNT/A (75...
The aim of the study was to characterize pattern transcript isoforms HTR2A exon II in lymphocytes blood as peripheral biomarkers schizophrenia development and effectiveness antipsychotic therapy. We primarily observed an increase mRNA levels elevation alternative variants a sample drug-naïve schizophrenic patients compared control group. There no association expression level with Antipsychotic-induced akathisia associated significant reduction studied isoforms. In summary, our results...