A5020382809- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Fatty Acid Research and Health
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Vagus Nerve Stimulation Research
- Prenatal Substance Exposure Effects
- Exercise and Physiological Responses
- Phytochemicals and Antioxidant Activities
- Migraine and Headache Studies
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Magnesium in Health and Disease
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Genomics, phytochemicals, and oxidative stress
- Memory and Neural Mechanisms
- Myofascial pain diagnosis and treatment
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Drug-Induced Hepatotoxicity and Protection
- Environmental Toxicology and Ecotoxicology
- Physiological and biochemical adaptations
Centre Hospitalier René-Dubos
2010-2025
Universidade Federal de Santa Maria
2014-2024
Dublin City University
2020-2023
Despite the unique and complex nature of cancer pain, activation different ion channels can be related to initiation maintenance pain. The transient receptor potential vanilloid 4 (TRPV4) is a cation channel broadly expressed in sensory afferent neurons. This activated by multiple stimuli mediate pain perception associated with inflammatory neuropathic Here, we focused on summarizing role TRPV4 etiology cancer-induced mechanisms. Many studies revealed that administration antagonist knockdown...
There is a major, unmet need for the treatment of cancer pain, and new targets medicines are required. The transient receptor potential ankyrin 1 (TRPA1), cation channel expressed by nociceptors, activated oxidizing substances to mediate pain-like responses in models inflammatory neuropathic pain. As known increase oxidative stress, role TRPA1 was evaluated mouse model Fourteen days after injection B16-F10 murine melanoma cells into plantar region right hind paw, C57BL/6 mice exhibited...
This study investigated the influence of neonatal handling on behavioral and biochemical consequences chronic mild stress (CMS) in adulthood. Male rat pups were submitted to daily tactile stimulation (TS) or maternal separation (MS), from postnatal day 1 (PND1) 21 (PND21), for 10 min/day. In adulthood, half number animals exposed CMS 3 weeks testing, including sucrose preference (SP), elevated plus maze (EPM), defensive burying tasks (DBTs), followed by assessments. reduced SP, increased...
Breast carcinoma causes severe pain, which decreases the quality of life patients. Current treatments produce adverse effects and have limited efficacy. Transient potential receptor ankyrin 1 (TRPA1) is related to onset cancer neuropathic pain. The aim this study was evaluate involvement TRPA1 in a model breast carcinoma. We injected 4T1 cells fourth caudal mammary fat pad female BALB/c mice, after 20 days we observed mechanical cold allodynia spontaneous nociception behavior (mouse grimace...
Abstract It is well known that events which occur in early life exert a significant influence on brain development, what can be reflected throughout adulthood. This study was carried out order to assess the of neonatal tactile stimulation (TS) behavioral and morphological responses related depression‐like anxiety‐like behaviors, assessed following administration sertraline (SERT), selective serotonin re‐uptake inhibitor (SSRI). Male pups were submitted daily TS, from postnatal day 8 (PND8)...
Recent studies have shown that tactile stimulation (TS) in pups is able to prevent and/or minimize fear, anxiety behaviors, and addiction psychostimulant drugs adult rats. In these studies, animals been exposed handling from postnatal day (PND) 1-21. This study was designed precisely establish which period of preweaning development has a greater influence TS on neuronal development. After birth, male were PND1-7, PND8-14, PND15-21. adulthood, the different periods assessed through...
In France, drug-related iatrogenesis is considered to be the cause of numerous emergency departments consultations and onset many disabling comorbidities in elderly people. Deprescribing potentially inappropriate drugs for older adults could help prevent this. However studies have shown that patients are reluctant take this approach. The aim study was describe barriers attitudes cared French geriatric network as regards deprescribing prescription. This a non-interventional, multicentric,...
The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined chronic daily maternal separation (MS) behavior cerebral morphology in both male female rats. Cognitive anxiety-like behaviors were evaluated, neuroplastic changes 2 subregions prefrontal cortex (dorsal agranular insular [AID] cingulate [Cg3]) hippocampus (CA1 dentate gyrus) measured adult animals...
Antineoplastic therapy has been associated with pain syndrome development characterized by acute and chronic pain. The chemotherapeutic agent dacarbazine, used mainly to treat metastatic melanoma, is reported cause painful symptoms, compromising patient quality of life. Evidence proposed that transient receptor potential ankyrin 1 (TRPA1) plays a critical role in chemotherapy‐induced syndrome. Here, we investigated whether dacarbazine causes hypersensitivity naive or melanoma‐bearing mice...
Central neuropathic pain is the main symptom caused by spinal cord lesion in relapsing-remitting multiple sclerosis (RRMS), but its management still not effective. The transient receptor potential ankyrin 1 (TRPA1) a detecting ion channel involved development. Thus, aim of our study was to evaluate role TRPA1 central nociception induced experimental autoimmune encephalomyelitis (RR-EAE) mouse model. In this model, we observed development similar clinical conditions RRMS C57BL/6 female mice...
The trafficking of transient receptor potential (TRP) channels to the plasma membrane and release calcitonin gene-related peptide (CGRP) from trigeminal ganglion neurons (TGNs) are implicated in some aspects chronic migraines. These exocytotic processes inhibited by cleavage SNAREs with botulinum neurotoxins (BoNTs); moreover, type A toxin (/A) clinically reduces frequency severity migraine attacks but not all patients for unknown reasons. Herein, neonatal rat TGNs were stimulated allyl...