A5077600021- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Resilience and Mental Health
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Evolutionary Psychology and Human Behavior
- Neural dynamics and brain function
- COVID-19 and Mental Health
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Anesthesia and Neurotoxicity Research
- Child and Adolescent Psychosocial and Emotional Development
- Psychological Well-being and Life Satisfaction
- Digital Mental Health Interventions
- Psychosomatic Disorders and Their Treatments
- Hormonal and reproductive studies
- Optimism, Hope, and Well-being
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- EEG and Brain-Computer Interfaces
- Mental Health Treatment and Access
- Neonatal and fetal brain pathology
Radboud University Medical Center
2016-2025
Radboud University Nijmegen
2016-2025
University Medical Center
2015-2025
Imec the Netherlands
2023
University of Zurich
2023
Leibniz Institute for Resilience Research
2022
Humboldt-Universität zu Berlin
2022
Technische Universität Dresden
2022
Freie Universität Berlin
2022
Charité - Universitätsmedizin Berlin
2022
Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout brain. We investigated brain-state shift in humans. During exposure fear-related acute stressor, responsiveness and interconnectivity within network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, temporoparietal) subcortical (amygdala, thalamus,...
The hippocampus is thought to promote gradual incorporation of novel information into long-term memory by binding, reactivating, and strengthening distributed cortical-cortical connections. Recent studies implicate a key role in this process for hippocampally driven crosstalk with the (ventro)medial prefrontal cortex (vmPFC), which proposed become central node such representational networks over time. existence relevant prior associative network, or schema, may moreover facilitate process....
Stressful, aversive events are extremely well remembered. Such a declarative memory enhancement is evidently beneficial for survival, but the same mechanism may become maladaptive and culminate in mental diseases such as posttraumatic stress disorder (PTSD). Stress hormones known to enhance postlearning consolidation of memories also thought have immediate effects on attentional, sensory, mnemonic processes at formation. Despite their significance our understanding etiology stress-related...
Abstract The SARS-CoV-2 pandemic is not only a threat to physical health but also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well their most important risk factors have been described, hardly anything known about potential protective factors. Resilience refers the maintenance of despite adversity. To gain mechanistic insights relationship between described resilience specifically current crisis, we...
Acute psychological stress can trigger normal and abnormal motivated behaviors such as reward seeking, habitual behavior, drug craving. Animal research suggests that effects may result from actions of catecholamines glucocorticoids converge in brain regions regulate incentive processing. At present, however, little is known about the acute on these circuits humans. During functional magnetic resonance imaging (fMRI), twenty-seven healthy young women performed a modified version monetary...
The ability to temporarily prioritize rapid and vigilant reactions over slower higher-order cognitive functions is essential for adaptive responding threat. This reprioritization believed reflect shifts in resource allocation between large-scale brain networks that support these functions, including the salience executive control networks. However, how changes communication within such dynamically unfold as a function of threat-related arousal remains unknown. To address this issue, we...
After encoding, memories undergo a process of consolidation that determines long-term retention. For conditioned fear, animal models postulate involves reactivations neuronal assemblies supporting fear learning during postlearning "offline" periods. However, no human studies to date have investigated such processes, particularly in relation expression fear. We tested 24 participants using functional MRI on 2 consecutive days conditioning paradigm involving 1 habituation block, acquisition...