A5089629236- Asymmetric Hydrogenation and Catalysis
- Geriatric Care and Nursing Homes
- Health and Medical Studies
- Surface Chemistry and Catalysis
- Health Systems, Economic Evaluations, Quality of Life
- Chemical Synthesis and Analysis
- Social and Demographic Issues in Germany
- Frailty in Older Adults
- Asymmetric Synthesis and Catalysis
- Psychiatric care and mental health services
- Catalysis for Biomass Conversion
- Nanomaterials for catalytic reactions
- Palliative Care and End-of-Life Issues
- Catalytic C–H Functionalization Methods
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- COVID-19 and Mental Health
- Emergency and Acute Care Studies
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Clinical practice guidelines implementation
- Chronic Disease Management Strategies
- Crystallization and Solubility Studies
- Medical Practices and Rehabilitation
- German Social Sciences and History
Martin Luther University Halle-Wittenberg
2015-2025
Luther University
2022
University of Rostock
2010-2014
University Hospital in Halle
2014
Leibniz Institute for Catalysis
2010-2013
Heidelberg University
2013
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2009
Leipzig University
2009
Philipps University of Marburg
2005
Jewish Board of Family and Children's Services
1993-1994
Control with an iron hand: A broad range of ketimines underwent enantioselective hydrogenation in the presence a chiral Brønsted catalyst and well-defined nonchiral (see scheme). This procedure constitutes attractive environmentally favorable alternative to well-established asymmetric reactions precious-metal catalysts.
In the iron age: A readily accessible, active catalyst serves in straightforward, catalytic transfer hydrogenation of imines (see scheme). series are converted into chiral amines high yields and very good enantioselectivities. This method should find broad application search for bioactive amines. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please...
EnvIRONmentally friendly: The title hydrogenation of aldehydes, ketones, and α,β-unsaturated aldehydes is reported. In the presence catalyst 1, primary, secondary, allylic alcohols were obtained in good to excellent yields under mild reaction conditions. easily inexpensively prepared, also stable air, water, column chromatography. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online...
Come together! A selective Fe-catalysed enantioselective reduction of quinoxalines and benzoxazines with hydrogen is demonstrated. Key to success the combination a chiral Brønsted acid well-defined non-chiral Fe hydrogenation catalyst. This methodology constitutes an attractive environmentally favourable alternative well-established asymmetric hydrogenations by using precious-metal-based catalysts.
Abstract The direct asymmetric reductive amination (DARA) of ketones with anilines is described by combining a chiral Brønsted acid (TRIP) and the non‐chiral Knölker iron complex as catalyst system. In situ‐ formed imines are reduced molecular hydrogen to give amines in high yields (90%) enantioselectivities up 99% ee . magnified image
Not so precious! The combination of copper acetate and chiral monodentate ligands allows the enantioselective hydrogenation carbonyl compounds to take place in good high yields with moderate enantioselectivities (see scheme).
Es geht auch günstiger: Die enantioselektive Hydrierung einer Vielzahl an Ketiminen gelang in Gegenwart eines chiralen Brønsted-Katalysators und genau definierten achiralen Eisenkatalysators (siehe Schema). Dieses Verfahren ist eine attraktive umweltfreundliche Alternative zu eingeführten asymmetrischen Hydrierungen mithilfe von Edelmetallkatalysatoren.
Enantiomerically pure chiral amines are of increasing importance and commercial value in the fine chemical, pharmaceutical, agrochemical industries. Here, we describe straightforward synthesis by combining atom-economic environmentally friendly hydroamination alkynes with an enantioselective hydrogenation situ generated imines using inexpensive hydrogen. By following this novel approach, a wide range terminal can be reductively hydroaminated primary including alkyl-, arylalkynes as well aryl...
To assess the quality of life people with dementia, measures are required for self-rating by person and proxy rating others. The Quality Life in Alzheimer's Disease scale (QoL-AD) is available two versions, QoL-AD-SR (self-rating) QoL-AD-PR (proxy rating). aim our study was to analyse inter-rater agreement between self- ratings, terms both total score items, including an analysis specific care setting, identify factors associated this agreement.
Moderne Eisenzeit: Ein einfach gebildeter aktiver Eisenkatalysator und eine simple Durchführung der Katalysereaktion unter sicheren milden Reaktionsbedingungen sind die besonderen Merkmale im Schema gezeigten Umsetzung, mit einer Reihe von Iminen sehr guten Enantioselektivitäten hohen Ausbeuten gelungen ist. Das macht Methode interessant für viele Anwendungen Labormaßstab. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents...
A will of iron: An iron-catalyzed reductive amination aldehydes and ketones with anilines using molecular hydrogen is presented. Under mild conditions, high yields for a broad range aryl, alkyl, heterocyclic as well are achieved.
Abstract The hydrogenation of imines to amines in the presence catalytic amounts zinc triflate has been demonstrated for first time. In addition, an efficient procedure reductive hydroamination alkynes is presented using as a catalyst precursor. both protocols variety different functional groups are tolerated, and reactions proceed smoothly high yields.
Importance For older adults with frailty syndrome, reducing polypharmacy may have utility as a safety-promoting treatment option. Objective To investigate the effects of family conferences on medication and clinical outcomes in community-dwelling receiving polypharmacy. Design, Setting, Participants This cluster randomized trial was conducted from April 30, 2019, to June 221, at 110 primary care practices Germany. The study included aged 70 years or daily use least 5 different medications,...
Eisen macht's einfach: Die Titelreaktion unter Verwendung von Katalysator 1 liefert primäre und sekundäre Alkohole sowie Allylalkohole in guten bis hervorragenden Ausbeuten milden Bedingungen. Der ist nicht teuer, leicht herstellbar beständig gegen Luft Wasser den Bedingungen der Säulenchromatographie. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not...
Person-centred care (PCC) has been suggested as the preferred model of dementia in all settings. The EPCentCare study showed that an adapted PCC approach was difficult to implement and had no effect on prescription antipsychotics nursing home residents Germany. This paper reports qualitative process evaluation identify facilitators barriers implementation German homes from perspective participating practice development champions.Five individual 14 group interviews were conducted with 66...
antipsychotic drugs are regularly prescribed as first-line treatment for neuropsychiatric symptoms in persons with dementia although guidelines clearly prioritise non-pharmacological interventions.we investigated a person-centred care approach, which has been successfully evaluated nursing homes the UK, and adapted it to German conditions.a 2-armed 12-month cluster-randomised controlled trial.nursing East, North West Germany.all prescribing physicians from both study arms received medication...
The first wave of the COVID-19 pandemic reached Germany between March and May 2020. In order to contain spread virus particularly protect vulnerable people, government imposed a lockdown in addition infection control measures, such as hygiene social distancing requirements, general ban on access nursing homes for relatives external service providers was issued.To investigate challenges consequences enacted prevention measures specific strategies Germany, multicentre cross-sectional...
Nursing prioritization and rationing decisions in acute care hospitals during the Covid-19 pandemic: a qualitative study Abstract:Background: The pandemic has put regarding of resources on health policy agenda. effects allocation nursing clinical practice are unclear. Aim: In order to derive implications for future situations, we analyzed extent which were made about distribution inpatient how bottlenecks dealt with. Methods: We conducted semi-structured interviews with staff (n = 16) team...
Abstract The first asymmetric hydrogenation/transfer hydrogenation of imines to amines using zinc(II) triflate in combination with chiral ligands is described. monodentate binaphthophosphepine ligand ( 3g ) provided the highest enantioselectivities. Using different imines, corresponding were obtained moderate yields and