A5087634932- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Prostate Cancer Treatment and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Spinal Cord Injury Research
- Ovarian cancer diagnosis and treatment
- S100 Proteins and Annexins
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
- Traumatic Brain Injury Research
- Mitochondrial Function and Pathology
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Venous Thromboembolism Diagnosis and Management
- Bone Tumor Diagnosis and Treatments
- Testicular diseases and treatments
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Pituitary Gland Disorders and Treatments
- Global Cancer Incidence and Screening
- Cancer, Stress, Anesthesia, and Immune Response
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Meningioma and schwannoma management
Neurological Surgery
2023-2025
University of California, San Francisco
2020-2025
Touro University California
2022-2025
University of California, Davis
2021-2024
University of Washington
2017-2024
Seattle University
2024
The Ohio State University
2022
UCSF Helen Diller Family Comprehensive Cancer Center
2020
Stockport NHS Foundation Trust
2012
Library and Archives Canada
2012
Internationally, the United States (U.S.) cites highest cost burden of low back pain (LBP). The continues to rise, faster than rate inflation and overall growth health expenditures. We performed a comprehensive literature review peer-reviewed non- from PubMed, Scopus, Google Scholar for contemporary data on prevalence, cost, projected future costs. Policymakers in U.S. have long attempted address high-cost LBP through limiting low-value services early imaging. Despite these efforts, costs...
Cancers and neurological disorders are two major types of diseases in humans. We developed the concept called “Aberrant Cell Cycle Disease (ACCD)” due to accumulating evidence that shows different share common mechanism aberrant cell cycle re-entry. The re-entry is manifested as kinase/oncoprotein activation tumor suppressor (TS) inactivation, which associated with both growth cancers neuronal death disorders. Therefore, some cancer therapies (e.g., kinase/oncogene inhibition TS elevation)...
To identify new therapeutic targets that limit glioblastoma (GBM) invasion, we applied druggable-genome CRISPR screens to patient-derived GBM cells in micro-dissectible biomimetic 3D hydrogel platforms permit separation and independent analysis of core vs. invasive fractions. We identified 12 whose suppression limited which ACP1 (LMW-PTP) Aurora Kinase B (AURKB) were validated neurosphere assays. Proximity labeling cortactin as an ACP1- AURKB link, undergoes serine phosphorylation by...
Introduction: Rathke's cleft cysts (RCCs) are benign sellar which can require operative management for symptoms such as headache, visual deficits, or endocrine dysfunction. Resection and fenestration the main surgical treatments RCCs. However, data on long-term outcomes to guide patient selection remains limited.
OBJECTIVE Tumor mutational burden (TMB) has been proposed as a prognostic biomarker in patients with metastatic cancer, well who receive immune checkpoint inhibitor (ICI) therapy. However, the role of TMB for progression after resection brain metastases, perioperative ICI treatment response, is less defined. This study examined impact on local CNS events underwent metastasis, those received postoperative treatment. METHODS was single-center, retrospective cohort adult clinical and molecular...
INTRODUCTION: The prognosis of patients with brain metastasis (BM) depends on patient and disease-specific factors. Although systemic disease status is a known BM prognostic factor, the extent this association postoperative outcomes has not been clearly elucidated. METHODS: A single center, retrospective study was conducted including who underwent resection over 20-year period. Patients were stratified based (stable/active vs no evidence disease). Outcomes included survival, time to CNS...
INTRODUCTION: The prognosis of patients with brain metastasis (BM) depends on patient and disease-specific factors. Intracranial disease burden may be associated postoperative outcomes such as survival CNS tumor progression, although the extent this association has not been clearly elucidated. METHODS: This was a retrospective, single-center cohort study including who underwent BM resection over 20-year period. Patients single those multiple BMs at time craniotomy were grouped separately....
INTRODUCTION: Neuroworsening, commonly defined as a declining Glasgow Coma Scale motor score (GCS-M), indicates injury progression and is component of traumatic brain (TBI) intensive care guidelines. The utility assessing neuroworsening in emergency department (ED) settings requires examination. METHODS: Adult subjects from the 18-center TRACK-TBI Study (enrollment years 2014-2018) with ED arrival GCS-M=6 disposition GCS-M were analyzed. Subjects received head CT <24h TBI. Neuroworsening...
Pediatric drug-resistant epilepsy (DRE) is defined as that not controlled by two or more appropriately chosen and dosed anti-seizure medications (ASMs). When alternative therapies surgical intervention viable efficacious, advanced options like deep brain stimulation (DBS) responsive neurostimulation (RNS) may be considered. Describe the Stanford early institutional experience with DBS RNS in pediatric DRE patients. Retrospective chart review of seizure characteristics, prior therapies,...
OBJECTIVE Cognitive impairment and pain catastrophizing are both associated with worse surgical outcomes. The aim of this study was to define the prevalence cognitive in patients adult spinal deformity (ASD) relationships between impairment, catastrophizing, patient-reported outcome measures (PROMs), frailty preoperative setting. METHODS This cross-sectional included undergoing evaluation for ASD correction at a single tertiary care center from January 2017 October 2024. Patients were...
Abstract BACKGROUND Docetaxel induces an anti‐tumor response in men with advanced prostate cancer (PCa); however, the side effects associated docetaxel treatment can be severe, resulting discontinuation of therapy. Thus, identification effective adjuvant therapy to allow lower doses is needed. Advanced PCa typically accompanied by skeletal metastasis. Receptor activator NFkB ligand (RANKL) a key pro‐osteoclastic factor. Targeting RANKL decreases establishment and progression growth bone...
Our previous studies demonstrated that traumatic brain injury (TBI) and ventricular administration of thrombin caused hippocampal neuron loss cognitive dysfunction via activation Src family kinases (SFKs). Based on SFK localization in brain, we hypothesized subtypes Fyn c-Src, as well downstream molecule Rho-associated protein kinase (ROCK), contribute to cell death after TBI. We administered nanoparticle wrapped small interfering RNA (siRNA)-Fyn siRNA-c-Src, or ROCK inhibitor Y-27632 adult...
Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that 'hybrid' neutrophils with dendritic features – including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide stimulate MHCII-dependent T cell activation accumulate intratumorally suppress tumor growth in vivo. Trajectory analysis patient TAN scRNA-seq identifies this phenotype as a polarization state which is distinct...
Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that 'hybrid' neutrophils with dendritic features - including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide stimulate MHCII-dependent T cell activation accumulate intratumorally suppress tumor growth