A5088602877- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- Electrostatics and Colloid Interactions
- NMR spectroscopy and applications
- Sperm and Testicular Function
- Cellular Mechanics and Interactions
- Characterization and Applications of Magnetic Nanoparticles
- Economic and Financial Impacts of Cancer
- Advanced Thermodynamics and Statistical Mechanics
- Ecosystem dynamics and resilience
- Nanopore and Nanochannel Transport Studies
- Reproductive Biology and Fertility
- Health Systems, Economic Evaluations, Quality of Life
- Lattice Boltzmann Simulation Studies
- Ovarian function and disorders
- Particle Dynamics in Fluid Flows
- Coronary Interventions and Diagnostics
- Microfluidic and Capillary Electrophoresis Applications
- Sports Dynamics and Biomechanics
- Plant Surface Properties and Treatments
- Orbital Angular Momentum in Optics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Innovation Policy and R&D
- Peripheral Artery Disease Management
- Acoustic Wave Resonator Technologies
Baim Institute for Clinical Research
2023
Beth Israel Deaconess Medical Center
2023
University of Birmingham
2017-2021
National Health Service
2019
Birmingham Women’s and Children’s NHS Foundation Trust
2019
Can flagellar analyses be scaled up to provide automated tracking of motile sperm, and does knowledge the waveform new insight not provided by routine head tracking?High-throughput analysis enable measurement experimentally intractable quantities such as energy dissipation, disturbance surrounding medium viscous stresses, which are possible sperm alone.The clinical gold standard for motility comprises a manual trained professional, with existing diagnostics [computer-aided (CASA)] relying on...
Summary Flagella are critical across all eukaryotic life, and the human sperm flagellum is crucial to natural fertility. Existing automated diagnostics (CASA) rely on tracking head extrapolating measures. We describe fully-automated analysis of flagellar movement for large cell numbers. The demonstrated freely-motile cells in low high viscosity fluids, validated published data tethered undergoing pharmacological hyperactivation. Direct beat reveals that CASA measure ‘beat cross frequency’,...
Taylor’s swimming sheet is a classical model of microscale propulsion and pumping. Many biological fluids substances are fibrous, having preferred direction in their microstructure; for example, cervical mucus formed polymer molecules which create an oriented fibrous network. Moreover, suspensions elongated motile cells produce form active matter. To understand how these effects modify viscous propulsion, we extend small-amplitude zero-Reynolds-number ‘swimming sheet’ via the transversely...
Suspensions of self-motile, elongated particles are a topic significant current interest, exemplifying form ‘active matter’. Examples include self-propelling bacteria, algae and sperm, artificial swimmers. Ericksen's model transversely isotropic fluid (Ericksen 1960 Colloid Polym. Sci. 173 , 117–122 ( doi:10.1007/bf01502416 )) treats suspensions non-motile as continuum with an evolving preferred direction; this describes fibrous materials diverse extracellular matrix, textile tufts plant...
We report a corrigendum to the paper 'Viscous propulsion in active transversely-isotropic media' [J. Fluid Mech. 812, 501-524, 2017 / arxiv 1608.01451].
Suspensions of self-motile, elongated particles are a topic significant current interest, exemplifying form `active matter'. Examples include self-propelling bacteria, algae and sperm, artificial swimmers. Ericksen's model transversely-isotropic fluid [J. L. Ericksen, Colloid Polym. Sci. 173(2):117-122 (1960)] treats suspensions non-motile as continuum with an evolving preferred direction; this describes fibrous materials diverse extracellular matrix, textile tufts plant cell walls....
Flow linear dichroism is a biophysical spectroscopic technique that exploits the shear-induced alignment of elongated particles in suspension. Motivated by broad aim optimising sensitivity this technique, and more specifically handheld synthetic biotechnology prototype for waterborne-pathogen detection, model steady oscillating pressure-driven channel flow orientation dynamics suspension slender microscopic fibres developed. The couples Fokker-Planck equation Brownian suspensions with narrow...
Flow linear dichroism is a biophysical spectroscopic technique that exploits the shear-induced alignment of elongated particles in suspension. Motivated by broad aim optimizing sensitivity this technique, and more specifically hand-held synthetic biotechnology prototype for waterborne-pathogen detection, model steady oscillating pressure-driven channel flow orientation dynamics suspension slender microscopic fibres developed. The couples Fokker–Planck equation Brownian suspensions with...