A5014677921- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Pluripotent Stem Cells Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Regulation of Appetite and Obesity
- CRISPR and Genetic Engineering
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- PARP inhibition in cancer therapy
- Receptor Mechanisms and Signaling
- Histone Deacetylase Inhibitors Research
- Analog and Mixed-Signal Circuit Design
- Cardiovascular Disease and Adiposity
- Biomedical Ethics and Regulation
- Cardiovascular Effects of Exercise
- Adipokines, Inflammation, and Metabolic Diseases
- GDF15 and Related Biomarkers
- Ubiquitin and proteasome pathways
- Cancer, Stress, Anesthesia, and Immune Response
Technische Universität Dresden
2020-2025
Max Planck Institute for Heart and Lung Research
2025
University Hospital Carl Gustav Carus
2020-2023
Carl Gustav Carus-Institut
2020
Charité - Universitätsmedizin Berlin
2012
MSB Medical School Berlin
2012
Protein homeostasis is crucial for maintaining cardiomyocyte (CM) function. Disruption of proteostasis results in accumulation protein aggregates causing cardiac pathologies such as hypertrophy, dilated cardiomyopathy (DCM), and heart failure. Here, we identify ubiquitin-specific peptidase 5 (USP5) a critical determinant quality control (PQC) CM. CM-specific loss mUsp5 leads to the polyubiquitin chains aggregates, remodeling, eventually DCM. USP5 interacts with key components machinery,...
Abstract The immaturity of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is a major limitation for their use in drug screening to identify pro-arrhythmogenic or cardiotoxic molecules. Here, we demonstrate an approach that combines lipid-enriched maturation medium with high concentration calcium, nanopatterning culture surfaces and electrostimulation generate iPSC-CMs advanced electrophysiological, structural metabolic phenotypes. Systematic testing reveals the key...
Cachexia, a common manifestation of malignant cancer, is not only associated with weight loss, but also severe cardiac atrophy and impaired function. Here, we investigated the effects ACM-001 (0.3 or 3 mg/kg/day) in comparison to carvedilol (3 30 mg/kg/day), metropolol (50 100 nebivolol (1 10 tertatolol (0.5 5 on mass function rat cancer cachexia model.Young male Wistar Han rats were inoculated i.p. 108 Yoshida hepatoma AH-130 cells treated once daily verum placebo by gavage. Cardiac...
In adult cardiomyocytes (CMs), the type 2 ryanodine receptor (RYR2) is an indispensable Ca2+ release channel that ensures integrity of excitation-contraction coupling, which fundamental for every heartbeat. However, role and importance RYR2 during human embryonic cardiac development are still poorly understood. Here, we generated two induced pluripotent stem cell (iPSC)-based knockout (RYR2–/–) lines using CRISPR/Cas9 gene editing technology. We found RYR2–/–-iPSCs could differentiate into...
Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) azithromycin (AZM) were used as a combination therapy in the treatment COVID-19 patients at beginning pandemic, leading to higher complication rates comparison respective monotherapies. Here, we human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) systematically investigate HCQ, AZM, on structure functionality...
Abstract Despite known adverse effects of hydroxychloroquine (HCQ) and azithromycin (AZM) on cardiac function, HCQ AZM have been used as combination therapy in the treatment COVID-19 patients. Recent clinical data indicate higher complication rates with HCQ/AZM comparison to monotherapy. Here, we human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) systematically investigate individually combination. The clinically observed QT prolongation caused by could be recapitulated...