A5025501054- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Travel-related health issues
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Erythropoietin and Anemia Treatment
- Long-Term Effects of COVID-19
- Blood properties and coagulation
- Exercise and Physiological Responses
- Cardiovascular and Diving-Related Complications
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- COVID-19 epidemiological studies
Universidad Peruana Cayetano Heredia
2016-2024
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1 , a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration Tibetans. We provide evidence for an association between adaptive variant (rs570553380) the same phenotype low hematocrit Andean highlanders. This Andean-specific missense present at modest frequency Andeans absent other populations vertebrate species except coelacanth....
Corante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Excessive erythrocytosis cardiovascular risk in Andean highlanders. High Alt Med Biol. 19:221-231, 2018.-Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection...
Excessive erythrocytosis (EE; hemoglobin concentration [Hb] ≥21 g/dL in adult males) is associated with increased cardiovascular risk highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated dilation (FMD) male Andeans without EE. hypothesized that FMD would be impaired EE after accounting for improve isovolemic hemodilution. Brachial artery were assessed 23 (age: 40±15 years [mean±SD]; Hb<21 g/dL) 19 43±14 years; Hb≥21 Cerro de Pasco, Peru...
High-altitude (HA) hypoxia may alter the structural-functional integrity of neurovascular unit (NVU). Herein, we compared male lowlanders (n = 9) at sea level (SL) and after 14 days acclimatization to 4300 m (chronic HA) in Cerro de Pasco (CdP), Péru (HA), against sex-, age- body mass index-matched healthy highlanders native CdP (lifelong HA). Venous blood was assayed for serum proteins reflecting NVU integrity, addition free radicals nitric oxide (NO). Regional cerebral flow (CBF) examined...
Thomson, Timothy M., Fresia Casas, Harold Andre Guerrero, Rómulo Figueroa-Mujíca, Francisco C. Villafuerte, and Claudia Machicado. Potential protective effect from COVID-19 conferred by altitude: A longitudinal analysis in Peru during full lockdown. High Alt Med Biol. 22: 209–224, 2021.
High-altitude (>2,500 m) exposure results in increased muscle sympathetic nervous activity (MSNA) acclimatizing lowlanders. However, little is known about how altitude affects MSNA indigenous high-altitude populations. Additionally, the relationship between and blood pressure regulation (i.e., neurovascular transduction) at unclear. We sought to determine 1) effects neurocardiovascular transduction 2) whether differences exist low- Measurements of (microneurography), mean arterial (MAP;...
Excessive erythrocytosis (EE) is the main sign of chronic mountain sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism EE still controversial, as physiological variability systemic respiratory, cardiovascular, hormonal responses to hypoxemia complicates identification underlying causes. Induced pluripotent stem cells derived from CMS highlanders showed increased expression genes relevant...
What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation blood pressure in Andean (Quechua) highlanders? main finding its importance? Compared to healthy highlanders, basal vasomotor outflow lower, muscle nerve activity similar, supine heart rate lower cardiovagal gain greater mild CMS. Taken together, these findings reflect flexibility integrative that may be important when viscosity volume are...
Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders. Low pulse O2 saturation (SpO2) during sleep and serum androgens have been suggested to contribute EE CMS patients. However, whether these factors significant impact on erythropoietin (Epo) system leading still unclear. We recently shown that morning soluble Epo receptor (sEpoR), an endogenous antagonist, decreased patients suggesting increased availability...
Excessive erythrocytosis [EE; hemoglobin concentration (Hb) ≥ 21 g/dL in adult men] is a maladaptive high-altitude pathology associated with increased cardiovascular risk and reduced reactive hyperemia flow-mediated dilation (FMD); however, whether similar impairment occurs response to more commonly encountered sustained increases shear stress [sustained stimulus (SS)-FMD] over range of overlapping stimuli unknown. We characterized SS-FMD handgrip exercise Andeans without EE Cerro de Pasco,...
The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear if indigenous highlanders CMS have altered volume regulatory hormones. We assessed NH 2 -terminal pro-B-type natriuretic peptide (NT pro-BNP), plasma aldosterone concentration, renin activity, kidney function (urinary microalbumin, rate), blood volume, estimated pulmonary...
High altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects microvesicles isolated from Andean highlanders EE on endothelial cell inflammation, oxidative stress, apoptosis, and nitric oxide (NO) production. Twenty-six male residents Cerro de Pasco, Peru (4,340 m), were studied: 12 without (age: 40 ± 4 yr; BMI: 26.4 1.7; Hb: 17.4 0.5 g/dL, Spo2: 86.9 1.0%) 14 (43 26.2 0.9; 24.4 0.4 g/dL;...
What is the central question of this study? effect sub-maximal aerobic exercise training on signs and symptoms chronic mountain sickness (CMS) in Andean highlanders? main finding its importance? Aerobic (ET) effectively reduces haematocrit, ameliorates improves capacity CMS patients, suggesting that a regular ET programme might be used as low-cost non-invasive/non-pharmacological management strategy syndrome.Excessive erythrocytosis hallmark sign (CMS), debilitating syndrome associated with...
Lowlander, Andean, and Sherpa arterial blood data were combined across five independent high-altitude expeditions in the United States, Nepal, Peru to assess acid-base status at ∼3,800, ∼4,300, ∼5,000 m. The main finding was that Andean highlander populations have more acidic blood, due elevated carbon dioxide similar bicarbonate compared with acclimatizing lowlanders altitudes ≥4,300
Male Andean highlanders with and without excessive erythrocytosis (EE) have similar peak V̇o 2 at 4,340 m, higher arterial [O ] in EE lower cardiac output (Q̇t), thus maintaining O delivery. Peak participants was unaffected by isovolumic hemodilution (hematocrit reduced from 67% to 53%), delivery balanced slightly increased Q̇t greater extraction. Differences lung muscle diffusing capacity, not hematocrit variation, accounted for essentially all interindividual variance .
BACKGROUND: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High (ie. Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent at altitude, though this has not been documented other groups, including those diagnosed with chronic mountain sickness (CMS). We investigated whether healthy (CMS-) and CMS afflicted (CMS+) Andeans exhibit cardiac under acute apneic stress altitude. METHODS AND RESULTS:...
Chronic mountain sickness (CMS) is commonly observed among Andean and other highland populations. Sleep-disordered breathing (SDB) highly prevalent at high altitude, SDB nocturnal hypoxemia have been in CMS. Phlebotomy performed to treat CMS, but it unknown whether reducing hematocrit improves SDB. We hypothesized that isovolemic hemodilution (IVHD) CMS would reduce SBD severity improve sleep efficiency.
Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive syndrome with significant prevalence in high‐altitude inhabitants. Although chronic hypoxemia represents its underlying stimulus, fundamental pathophysiological mechanism still debatable. Studies during sleep CMS patients consistently find lower average pulse O 2 saturation (SpO ) compared to healthy highlanders (HH). Although, whether accentuated has impact on Epo system that could explain...
What is the central question of this study? Are coagulation and fibrinolytic factors disrupted in Andean highlanders with excessive erythrocytosis? main finding its importance? Excessive erythrocytosis not associated prothombotic disruptions or system highlanders. Impairments fibrinolysis may contribute to increased vascular risk erythrocytosis.Increased reduced are underlying thrombotic events. High altitude-induced (EE) prevalent highlanders, contributing cardiovascular risk. Disruption...
Excessive erythrocytosis (EE; Hct ≥ 63% in men) is the hallmark of Monge’s disease or Chronic Mountain Sickness (CMS), a debilitating syndrome with high prevalence Andean highlanders. EE associated typical CMS neurological symptoms and increased cardiovascular risk. Although largely impractical, common treatment includes relocation individuals to lower altitudes, periodic bloodletting hemodilution. We have shown that, unlike sedentary residents at same altitude, high‐altitude (HA) athletes...
Excessive erythrocytosis is the hallmark of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome common in Andeans that thought to negatively impact oxygen transport and exercise capacity. We performed cardiopulmonary testing at 4350m both healthy males (controls) those with CMS pre‐ post‐isovolemic hemodilution (n = 8 controls, n 6 CMS) determine whether they differed capacity as function hematocrit (Hct). Hct significantly between control (Hct=51.6±4.0) pre‐hemodilution...
Abstract The COVID-19 pandemic had a delayed onset in South America compared to Asia (outside of China), Europe or North America. In spite the presumed time advantage for implementation preventive measures help contain its spread, that region followed growth rates paralleled, and currently exceed, those observed several weeks before Europe. Indeed, early August 2020, many countries Central presented among highest world confirmed cases deaths per million inhabitants. Here, we have taken an...