A5026679178- Antibiotic Resistance in Bacteria
- Leptospirosis research and findings
- Vibrio bacteria research studies
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Cytomegalovirus and herpesvirus research
- Veterinary medicine and infectious diseases
- Salmonella and Campylobacter epidemiology
- Mycobacterium research and diagnosis
- Bioactive Compounds and Antitumor Agents
Institute of Biomedical Science
2025
Universidade de São Paulo
2021-2023
University of Birmingham
2022
Harvard University
2022
The type VI secretion system (T6SS) secretes antibacterial effectors into target competitors. Salmonella spp. encode five phylogenetically distinct T6SSs. Here, we characterize the function of SPI-22 T6SS bongori showing that it has activity and identify a group (TseV1–4) containing an N-terminal PAAR-like domain C-terminal VRR-Nuc encoded next to cognate immunity proteins with DUF3396 (TsiV1–4). TseV2 TseV3 are toxic when expressed in Escherichia coli bacterial competition assays confirm...
The Leptospiraceae family, which includes the genera Leptospira, Leptonema, and Turneriella, is an ecologically diverse group that saprophytic strains from soil water as well important pathogenic strains. Adaptation to these multiple environments relies strongly on signal transduction adjust their morphology, motility, metabolism changing environmental conditions. Members of genus Leptospira distinguish themselves among spirochetes for having elevated number genes. In this study, we describe...
Cyclic di-GMP (bis-(3′ → 5′) cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation. Its intracellular levels are dynamically controlled by diguanylate cyclases (DGCs), which synthesize c-di-GMP from GTP, phosphodiesterases (PDEs), degrade it into linear pGpG or GMP. The functional effects cytoplasmic mediated through diverse effector...
Abstract The T6SS (Type VI secretion System) secretes antibacterial effectors into target competitors. Salmonella spp. encode five phylogenetically distinct T6SSs. Here we characterize the function of SPI-22 S. bongori , showing that it has activity. We identify a group (TseV1-4) containing an N-terminal PAAR-like domain and C-terminal VRR-Nuc encoded next to cognate immunity proteins contain DUF3396 (TsiV1-4). TseV2 TseV3 are toxic when expressed in Escherichia coli bacterial competition...
Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, contact-dependent effectors that are either secreted medium directly translocated into target cells. During bacterial antagonistic encounters, several cellular components important life become a weak spot prone attack. Nucleic acids machinery responsible their...