A5075089949- Congenital heart defects research
- Semiconductor materials and devices
- Angiogenesis and VEGF in Cancer
- Electrokinetic Soil Remediation Techniques
- Renal and related cancers
- Force Microscopy Techniques and Applications
- melanin and skin pigmentation
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Electrohydrodynamics and Fluid Dynamics
- Boron and Carbon Nanomaterials Research
- Kruppel-like factors research
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Electrostatics and Colloid Interactions
- thermodynamics and calorimetric analyses
- Underwater Acoustics Research
- Microfluidic and Capillary Electrophoresis Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Surface and Thin Film Phenomena
- Autophagy in Disease and Therapy
- Geophysical and Geoelectrical Methods
- Photonic and Optical Devices
- Protein Degradation and Inhibitors
- Plasmonic and Surface Plasmon Research
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2024
University of Turin
2012-2024
Candiolo Cancer Institute
2009-2024
NS Kurnakova Institute of General and Inorganic Chemistry
2012
Petroleum of Venezuela (Venezuela)
2002
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display defects that differ from those of mice lacking either or Sema3A proteins. Furthermore, it has been recently reported required cell (EC) response to both VEGF-A165 VEGF-A121 isoforms, the latter being incapable binding on EC surface. Taken together, these data suggest phenotype caused by loss could be due...
Abstract Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-mediated extracellular FN endocytosis exocytosis newly synthesized remain elusive. Here we show that, on Rab21-elicited internalization, FN-bound/active is recycled to the EC surface. We identify pathway, comprising regulators post-Golgi carrier formation PI4KB AP-1A, small GTPase Rab11B, surface...
Article27 December 2018Open Access Source DataTransparent process TFEB controls vascular development by regulating the proliferation of endothelial cells Gabriella Doronzo Corresponding Author [email protected] orcid.org/0000-0002-3693-8178 Department Oncology, University Turin, Candiolo, Italy Candiolo Cancer Institute-FPO-IRCCS, Search for more papers this author Elena Astanina Davide Corà Translational Medicine, Piemonte Orientale University, Novara, Giulia Chiabotto Medical Sciences,...
The events occurring during tumor formation and progression display similarities to some of the steps in embryonic morphogenesis. family AP-2 proteins consists five different transcription factors (alpha, beta, gamma, delta, epsilon) that play relevant roles development, as demonstrated by phenotypes corresponding knockout mice. Here, we show AP-2alpha AP-2gamma an essential role tumorigenesis. Down-modulation expression cells RNA interference (RNAi) led enhanced growth reduced...
The dynamic integrin-mediated adhesion of endothelial cells (ECs) to the surrounding ECM is fundamental for angiogenesis both in physiological and pathological conditions, such as embryonic development cancer progression. dynamics EC-to-ECM adhesions relies on regulation conformational activation trafficking integrins. Here, we reveal that oncogenic transcription factor EB (TFEB), a known regulator lysosomal biogenesis metabolism, also controls transcriptional program influences turnover ECs...
Abstract Melanomas are characterised by accelerated cell proliferation and metabolic reprogramming resulting from the contemporary dysregulation of MAPK pathway, glycolysis tricarboxylic acid (TCA) cycle. Here, we suggest that oncogenic transcription factor EB (TFEB), a key regulator lysosomal biogenesis function, controls melanoma tumour growth through transcriptional programme targeting ERK1/2 activity glucose, glutamine cholesterol metabolism. Mechanistically, TFEB binds negatively...
In non-small cell lung cancer (NSCLC) the efficacy of chemo-immunotherapy is affected by high expression drug efflux transporters as ABCC1 and low ABCA1, mediating isopentenyl pyrophosphate (IPP)-dependent anti-tumor activation Vγ9Vδ2 T-lymphocytes. endothelial cells ABCA1 a predicted target transcription factor EB (TFEB), but no data exists on correlation between TFEB ABC involved in chemo-immuno-resistance NSCLC.
Abstract Epithelial-mesenchymal transition (EMT) is a complex and pivotal process involved in organogenesis related to several pathological processes, including cancer fibrosis. During heart development, EMT mediates the conversion of epicardial cells into vascular smooth muscle cardiac interstitial fibroblasts. Here, we show that oncogenic transcription factor EB (TFEB) key regulator its genetic overexpression mouse epicardium lethal due defects linked impaired EMT. TFEB specifically...
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as regulators EMT processes; however, the mechanisms by which miRNAs target epicardial remain largely unknown. Here, using an vitro model of EMT, we investigated role this process and their potential targets. was induced murine epicardial-mesothelial cells (EMCs) through TGF β1 treatment...
Abstract Embryonic stem cells (ES) are a valuable source of endothelial cells. By co-culturing ES with the stromal PA6 cells, commitment can be achieved by adding exogenous FGF2 or BMP4. In this work, molecular pathways that direct differentiation toward endothelium in response to evaluated and compared those activated To purpose genes expression profiles both ES/PA6 co-cultures pure cultures were obtained microarray technique at different time points. The bioinformatics processing data...