A5030756660- Hops Chemistry and Applications
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Phytochemicals and Antioxidant Activities
- Pharmacology and Obesity Treatment
- Obesity and Health Practices
- Nutrition and Health in Aging
- Pharmacogenetics and Drug Metabolism
- Vitamin C and Antioxidants Research
- Chromatography in Natural Products
- Berberine and alkaloids research
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- PI3K/AKT/mTOR signaling in cancer
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Nitric Oxide and Endothelin Effects
- Body Composition Measurement Techniques
Migration Institute of Australia
2022
Hypertension Institute
2017
St. Thomas Medical Group
2017
Saint Thomas West Hospital
2017
Banyan Biomarkers (United States)
2016
New York Proton Center
2016
The Ohio State University
2015
Psychogenics (United States)
2007-2014
Digital Proteomics (United States)
2007-2010
MultiCare Gig Harbor Medical Park
2008
The working definition of health is often the simple absence diagnosed disease. This common standard limiting given that changes in functional status represent early warning signs impending declines. Longitudinal assessment may foster prevention disease occurrence and modify progression. LIFEHOUSE (Lifestyle Intervention Functional Evaluation-Health Outcomes SurvEy) longitudinal research project explores impact personalized lifestyle medicine approaches on determinants. Utilizing an adaptive...
As the worldwide dietary pattern becomes more westernized, metabolic syndrome is reaching epidemic proportions. Lifestyle modifications including diet and exercise are recommended as first-line intervention for treating syndrome. Previously, we reported that a modified Mediterranean-style, low glycemic load with soy protein phytosterols had favorable impact than American Heart Association Step 1 on cardiovascular disease (CVD) risk factors. Subsequently, screened phytochemicals history of...
The lipophilic extracts of the common hops (Humulus lupulus) contain compounds that are readily modified to family isohumulones (e.g., iso-alpha acids). have been found reduce metabolic inflammation and insulin resistance, positively impact dyslipidemia obesity. These effects consistent across studies in multiple cell lines, animal model systems human intervention trials. Mechanistic work has demonstrated these a unique pleiotropic mechanism action which is with their safety range...
In this report, we examine the clinical safety and efficacy of NG440, a phytochemical-based antiinflammatory formula consisting combination rho iso-alpha acids from hops, rosemary, oleanolic acid. previous study, demonstrated that NG440 significantly decreased pain by 50% in patients with osteoarthritis. Consistent these data, results multicentre trial indicate reduced scores joint discomfort, as measured VAS (visual analog scale) methodology. As an ex vivo effects on relief may be due to...
An open-label, randomized, exploratory study of 44 healthy overweight subjects with cardio-metabolic syndrome (CMS) risk factors was conducted to assess the safety, tolerability, and efficacy a proprietary lifestyle modification program without (DIET) (PROG) targeted nutraceutical supplementation, including phytosterols, antioxidants, probiotics, fish oil, berberine, soy, pea, whey proteins over 13 weeks. Key metrics were recorded at baseline weeks 9 13. For DIET PROG groups, compliance 85%...
We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. is a combination bergamot fruit extract (Citrus bergamia, BFE) 9 phytoextracts selected for their ability to improve antioxidant anti-inflammatory activity BFE. In vitro exhibited synergistic inhibition oxygen radical absorbing capacity, peroxynitrite formation, myeloperoxidase activity. Following 12 weeks daily, no treatment-related adverse events or changes body mass were seen. Statistically...
Among the comorbidities of high body mass index, cardiovascular disease continued to be leading cause death and disability globally in 2015, while type 2 diabetes remained second. The primary objectives this observational study were confirm safety, tolerability, efficacy our calorie-restricted Mediterranean diet with targeted dietary supplementation (PROG1) using recognized supplementation. Fifty healthy overweight obese subjects cardiometabolic risk factors assigned a modified diet,...
The gastrointestinal (GI) impact of fibers including resistant starch (RS) consumption depends on various types and amounts fibers, the initial microbiome states, accurate intake measurements. A randomized clinical trial evaluated GI varying doses a novel blend (RSB) with smart cap monitoring. RSB contained at least 50% RS was proprietary mixture potato starch, green banana flour, apple fiber powder (a source pectin, not starch). study design participants to one four arms: 10 g/day (0 RSB),...
During the last decade, great strides have been made to delineate importance of diet in prevention and treatment metabolic syndrome. Dietary recommendations emphasized a low-fat ("antiatherogenic") as first-line therapeutic approach. However, complex etiology syndrome would seem necessitate tailored dietary approaches beyond simple macronutrient modification. Current data revealed varying biological effects individual macronutrients within same category, suggesting that adjusting percentages...
A multivitamin-multimineral supplement combined with a diverse blend of bioactive phytochemicals may provide additional antioxidant capacity and anti-inflammatory property for overall health. This convenient feature be useful individuals who want to increase their intake phytochemicals.We conducted pilot study in 15 healthy (8 women 7 men, mean age 41.7±14.9 years, body mass index 28.0±5.6) investigate the effects this novel formulation on biomarkers associated oxidative stress inflammation....
Niacin favorably modifies cardiovascular risk factors but is associated with flushing and shows limited benefit in improving endothelial function. We investigated whether combining anti-inflammatory tetrahydro-iso-alpha acids (THIAA) from hops niacin would improve hypothesized that the THIAA+niacin combination demonstrate benefits not seen alone. In an vitro model, a mixture inhibited several TNF-α-induced cytokines human aortic cells monocytic was significantly more efficacious than...
In search of phytochemicals with anti‐inflammatory properties – which may also be useful in obesity management we discovered candidate META060, a family substituted‐1,3‐cyclopentadiones derived from hops. vitro, META060 inhibited kinases (e.g. PI3Kβ/δ/γ, GSK3α/β, BTK and SYK) involved NF‐κB pathway reduced nuclear abundance. It inducible COX‐2 iNOS abundance PGE 2 nitric oxide production LPS‐stimulated macrophages. vivo, acute chronic inflammation arthritic mice, lowered fasting glucose...
Each individual has a unique and interacting set of genetic, lifestyle, environmental factors that are reflected in their physical exam laboratory biomarkers significantly impact experience health. Patterns nutrient deficiency signs biomarker levels below health-promoting thresholds have been identified national nutrition surveys. However, identifying these patterns remains challenge clinical medicine for many reasons, including clinician training education, time restraints, the belief both...
As cardiovascular disease risk is increased 4–6 fold in subjects when metabolic syndrome (MetS) and elevated LDL occur concomitantly, we evaluated effects of supplementing a therapeutic lifestyle program with medical food specific combination phytonutrients both conditions. We analyzed data from ≥ 160 mg/dL enrolled 12‐week, 2‐arm randomized study 42 adults MetS, ≥130 mg/dL, triglyceride (TG) ≥150<400 BMI ≥27 kg/m 2 . Both control (C) treatment (T) arms consumed Mediterranean‐style,...