A5100625560- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Nanopore and Nanochannel Transport Studies
- Plant-based Medicinal Research
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Sphingolipid Metabolism and Signaling
- Epilepsy research and treatment
- Plant Reproductive Biology
- melanin and skin pigmentation
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Bioactive natural compounds
- Connexins and lens biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cystic Fibrosis Research Advances
- Chromosomal and Genetic Variations
- Neonatal Respiratory Health Research
Tongji University
2024
First Hospital of Jilin University
2019-2023
Jilin University
2019-2023
Peking University
2022
Nanjing University of Chinese Medicine
2022
Chongqing University of Education
2020
University of California, San Francisco
2018
Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer's disease (AD). With heat-clearing detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used treat dementia improve learning memory impairments.To study therapeutic effect HLJDD on AD as it relates metabolism.The level sphingolipids in brains APP/PS1 mice supernatant β-amyloid (Aβ)25-35-induced BV2 microglia was detected by HPLC-QTOF-MS HPLC-QTRAP-MS techniques, respectively. The...
We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole exome sequencing 511 trios. Here, we an additional 291 TD trios and analyze combined set 802 observe overrepresentation in simplex but not multiplex families; identify two new high confidence risk genes, CELSR3 (Cadherin EGF LAG Seven-Pass G-Type Receptor 3) OPA1 (Mitochondrial Dynamin-Like GTPase); find that genes mutated patients are enriched for those related cell...
While the pathogen nucleic acid diagnostic technology has made tremendous progresses, several challenges, including long development cycles and limited specificity still exist, especially in context of isothermal amplification techniques. To enhance detection accuracy, here a functional strand displacement catalytic hairpin assembly circuit, which can perform at high-temperature (HT-CHA), was developed as downstream loop mediated (LAMP). The addition HT-CHA not only ensures but also...
A sensitive and rapid bioanalytical method based on the LC-triple-stage fragmentation (LC-MS3) strategy a hybrid triple quadrupole-linear ion trap mass spectrometer in combination with protein precipitation extraction for sample pretreatment has been developed validated simultaneous determination of antiepileptic drug oxcarbazepine (OXC) its main active metabolite (MHD) human serum. The separation was performed Waters XBridge BEH C18 column (2.5 µm, 2.1 × 50 mm) isocratic elution 0.1% formic...