A5054084620- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Neurotransmitter Receptor Influence on Behavior
- Cardiac Arrest and Resuscitation
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Thermal Regulation in Medicine
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Zebrafish Biomedical Research Applications
VA Puget Sound Health Care System
2020-2024
Geriatric Research Education and Clinical Center
2020-2024
University of Puget Sound
2020-2024
VA Northwest Network
2020-2024
University of Washington
2020-2023
Seattle University
2020
Mild traumatic brain injury (mTBI) has emerged as a potential risk factor for the development of neurodegenerative conditions such Alzheimer's disease and chronic encephalopathy. Blast mTBI, caused by exposure to pressure wave from an explosion, is predominantly experienced military personnel increased in prevalence severity recent decades. Yet underlying pathology blast mTBI largely unknown. We examined expression localization AQP4 human post-mortem frontal cortex observed distinct laminar...
Abstract Background Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military service members. mTBI can increase health risk behaviors (e.g., sensation seeking, impulsivity) addiction for alcohol use disorder (AUD)), but how substance might interact to promote remains poorly understood. Likewise, potential differences single vs. repetitive relation use/abuse have not been previously examined. Methods Here, we examined a history of (1×) or (3×) blast...
Opioid use disorder (OUD) has become a leading cause of death in the United States, yet current therapeutic strategies remain highly inadequate. To identify potential treatments for OUD, we screened targeted selection over 100 drugs using recently developed opioid self-administration assay zebrafish. This paradigm showed that finasteride, steroidogenesis inhibitor approved treatment benign prostatic hyperplasia and androgenetic alopecia, reduced multiple opioids without affecting locomotion...
Despite impressive results from neuroscience research using rodent models, there is a paucity of successful translation preclinical findings to effective pharmacological interventions for treatment substance use disorder (SUD) in humans. One potential reason lack animal models difficulty accurately replicating the lived experience people who drugs. Aspects humans that are often not modeled include but limited 1) voluntary timing and frequency intake, 2) social environment during use, 3)...
Repetitive mild traumatic brain injury (mTBI) has been called the "signature injury" of military service members in Iraq and Afghanistan wars is highly comorbid with post-traumatic stress disorder (PTSD). Correct attribution adverse blast-induced mTBI and/or PTSD remains challenging. Pre-clinical research using animal models can provide important insight into mechanisms by which blast produces dysfunction-but only to degree such reflect human experience. Avoidance trauma reminders a hallmark...
Adverse pathophysiological and behavioral outcomes related to mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), chronic pain are common following blast exposure contribute decreased quality of life, but underlying mechanisms prophylactic/treatment options remain limited. The dynorphin/kappa opioid receptor (KOR) system helps regulate inflammatory responses injury; however, it has yet be investigated as a potential mechanism in either humans or animals exposed blast....
Blast exposure (via detonation of high explosives) represents a major potential trauma source for Servicemembers and Veterans, often resulting in mild traumatic brain injury (mTBI). Executive dysfunction (e.g., alterations memory, deficits mental flexibility, difficulty with adaptability) is commonly reported by Veterans history blast-related mTBI, leading to impaired daily functioning decreased quality life, but underlying mechanisms are not fully understood have been well studied animal...
Abstract Polysubstance use is prevalent in the population but remains understudied preclinical models. Alcohol and opioid polysubstance associated with negative outcomes, worse treatment prognosis, higher overdose risk; underlying mechanisms are still being uncovered. Examining factors that motivate of one substance over another different contexts models will better our understanding improve translational value. Here we assessed baseline anxiety-like locomotive behavior then measured...
ABSTRACT Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military Servicemembers contact sports athletes. mTBI, especially within populations, often comorbid with posttraumatic stress disorder (PTSD), can increase health-risk behaviors (e.g., sensation/novelty seeking, impulsivity, risk taking, irritability/aggression) substance misuse/abuse, but underlying mechanisms remain poorly understood. Using an established mouse model of blast here we examined the...
Abstract Dopamine transmission is implicated in aberrant behaviors associated with substance use disorders. Previous research revealed a causal link between excessive drug consumption and the loss of dopamine signaling to stimuli psychostimulant use. The emerging change specific rather than pharmacological properties itself. Because was not substance, we examined if treatment precursor, L-DOPA, alters alcohol opioid self-administration. Therefore, trained rats orally self-administer ethanol...
Abstract Opioid use disorder (OUD) has become a leading cause of death in the US, yet current therapeutic strategies remain highly inadequate. To identify novel potential treatments for OUD, we screened targeted selection over 100 drugs, using recently developed opioid self-administration assay zebrafish. This paradigm showed that finasteride, steroidogenesis inhibitor approved treatment benign prostatic hyperplasia and androgenetic alopecia, reduced multiple opioids without affecting...
ABSTRACT Background Adverse pathophysiological and behavioral outcomes related to mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), chronic pain are common following blast exposure contribute decreased quality of life, but underlying mechanisms prophylactic/treatment options remain limited. The dynorphin/kappa opioid receptor (KOR) system helps regulate inflammatory responses injury; however, it has yet be investigated as a potential mechanism in either humans or...
Abstract Background Repetitive blast-related mild traumatic brain injury (mTBI) caused by exposure to high explosives is increasingly common among warfighters as well civilians. While women have been serving in military positions with increased risk of blast since 2016, there are few published reports examining sex a biological variable models mTBI, greatly limiting diagnosis and treatment capabilities. As such, here we examined acute chronic outcomes repetitive trauma female male mice...
Abstract Despite impressive results from neuroscience research using rodent models, there is a paucity of successful translation preclinical findings to effective pharmacological interventions for treatment substance use disorder (SUD) in humans. One potential reason lack animal models difficulty accurately replicating the lived experience people who drugs. Aspects humans that are often not modeled include but limited 1) voluntary timing and frequency intake, 2) social environment during...