A5082660440- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- COVID-19 and Mental Health
- Stress Responses and Cortisol
- Sleep and related disorders
- Intensive Care Unit Cognitive Disorders
- Cognitive Functions and Memory
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Intimate Partner and Family Violence
- Olfactory and Sensory Function Studies
- Healthcare professionals’ stress and burnout
- Mental Health Treatment and Access
- Long-Term Effects of COVID-19
- Meta-analysis and systematic reviews
- COVID-19 and healthcare impacts
- Counseling Practices and Supervision
- Substance Abuse Treatment and Outcomes
- Dementia and Cognitive Impairment Research
- Health Policy Implementation Science
- Pain Management and Placebo Effect
- Burn Injury Management and Outcomes
- Sexual Assault and Victimization Studies
VA Northwest Network
2016-2025
Mental Illness Research, Education and Clinical Centers
2016-2025
University of Washington
2016-2025
VA Puget Sound Health Care System
2017-2025
United States Department of Veterans Affairs
2025
University of Puget Sound
2020-2022
Seattle University
2016-2018
Washington University in St. Louis
2008
The COVID-19 pandemic has greatly affected front-line health care workers (HCW) and first responders (FR). specific components of related occupational stressors (CROS) associated with psychiatric symptoms reduced functioning or retention remain poorly understood.Examine the relationships between total factored CROS, symptoms, outcomes.Observational, self-report, single time-point online assessment.A 510 US HCW (N = 301) FR 200) duties by pandemic.CROS were assessed using a custom 17-item...
Laterally connected inhibitory circuitry is found throughout the nervous system, including many early sensory processing systems. The extent to which it plays a role in shaping neuronal stimulus selectivity systems like olfaction, however, lack simple two-dimensional representation of their space, has remained controversial. We examined this issue using an experimental preparation that allowed electrophysiological recording from accessory olfactory bulb anesthetized mouse during controlled...
Abstract Objectives: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Iraqi (OIF), New Dawn (OND) Veterans with without a self-reported history of blast-related mild traumatic brain injury (mTBI). Methods: Sixty-one OEF/OIF/OND Veterans, including mTBI (mTBI group; n =42) TBI (control =19) completed the Memory for Intentions Test, measure (PM), two measures (RM), California Verbal Learning Test-II Brief Visuospatial Test-Revised. Results: group...
Increases in the quantity or impact of noradrenergic signaling have been implicated pathophysiology posttraumatic stress disorder (PTSD). This increased may result from norepinephrine (NE) release, altered brain responses to NE, a combination both factors. Here, we tested hypothesis that Veterans reporting history trauma exposure would show an association between NE and mental health symptoms commonly observed after trauma, as compared who did not report exposure, consistent with possibility...
Abstract Evidence describing the association between sleep quality and trauma‐focused therapy is mixed. This secondary analysis of a primary care sample examined whether (a) baseline moderated posttraumatic stress disorder (PTSD) symptom severity over time across groups receiving different doses cognitive processing (CPT) (b) improved with CPT. Participants were 227 adults who screened positive for PTSD participating in clinical trial comparing two models treatment delivery care. The...
Gaps exist in the delivery of effective, culturally mindful treatment for trauma-related mental health problems, and providers who treat those problems underresourced communities need more support. Adapting Project ECHO (Extension Community Healthcare Outcomes), authors developed a virtual learning community to link Washington State with specialists trauma recovery. Goals were evaluate provider demand trauma-specific training project's feasibility, acceptability, initial impacts on...
Abstract Background Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military service members. mTBI can increase health risk behaviors (e.g., sensation seeking, impulsivity) addiction for alcohol use disorder (AUD)), but how substance might interact to promote remains poorly understood. Likewise, potential differences single vs. repetitive relation use/abuse have not been previously examined. Methods Here, we examined a history of (1×) or (3×) blast...
Abstract Introduction Nightmares and sleep disruption are hallmarks of posttraumatic stress disorder (PTSD), cause significant distress, often persist after the remission other symptoms. Autonomic dysregulation, including tachycardia, excessive sweating, panic, have been implicated in pathophysiology PTSD. Existing self-report measures for nightmares disrupted primarily focus on subsets relevant clinical features, with relatively little emphasis symptoms autonomic dysregulation during sleep,...
Abstract Introduction The proposed clinical phenotype of trauma-associated sleep disorder (TASD) includes repetitive trauma nightmares, dream enacting behaviors, and nighttime autonomic symptoms. Symptoms overlap with post-traumatic stress (PTSD), rapid eye movement behavior (RBD) obstructive apnea (OSA). TASD is clinically relevant given high rates disturbances known associations between RBD neurodegeneration. However, not formally recognized, more research needed on its epidemiology...
Abstract Introduction Adults with post-traumatic stress disorder (PTSD) have a significantly increased risk for developing dementia. With previous work linking sleep-related glymphatic dysfunction to neurodegeneration, sleep disturbances in PTSD are potential target decreasing this risk. Clinical trials demonstrated prazosin, an alpha-1-antagonist, improves quality by nightmares Veterans PTSD, and rodent showed prazosin flow. Here, we investigate the effect of on dementia clinical...
Introduction: This study investigated variables associated with subjective decline in executive function among Veterans of Operations Enduring Freedom, Iraqi and New Dawn (OEF/OIF/OND) following a history blast-related mild traumatic brain injury (mTBI).Method: Fifty-six male U.S. (MAge = 35.3 ± 8.8 years) mTBI (6.6 3.2 years post injury) completed battery self-report questionnaires neuropsychological measures. Participants rated current retrospectively estimated pre-mTBI difficulties on the...
Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions. However, PG-RCTs provide limited information about individuals, making them poorly optimized quantifying relationship of a biomarker measured at baseline with response. In N-of-1 trials, an individual subject moves between conditions to determine their specific response each treatment. Aggregated analyze cohort...
Objective: Memory problems that affect daily functioning are a frequent complaint among Veterans reporting history of repetitive mild traumatic brain injury (mTBI), especially in cohorts with comorbid PTSD. Here, we test the degree to which subjective sleep impairment and daytime fatigue account for association PTSD self-reported mTBI prospective memory. Method: 82 without personal repeated blast-related during deployment were administered Clinician Administered Scale (CAPS), Intentions Test...
The α1-adrenoreceptor antagonist prazosin has in many but not all studies been found to be effective for PTSD associated nightmares, hyperarousal symptoms, and total symptom severity. particular efficacy of nightmares symptoms suggests there may a subset that are more tightly with an mediated noradrenergic mechanism, cross traditional diagnostic clusters. However, the individual other than sleep disruption previously examined.In post hoc reanalysis published, randomized controlled trial...
Abstract Background Excessive noradrenergic signaling contributes to aversive symptoms of alcohol withdrawal that interfere with abstinence or reductions in harmful use. Methods To address this aspect use disorder, 102 active‐duty soldiers participating command‐mandated Army outpatient treatment were randomized also receive the brain‐penetrant alpha‐1 adrenergic receptor antagonist prazosin placebo for 13 weeks. Primary outcomes scores on Penn Alcohol Craving Scale (PACS), standard drink...
Blast exposure (via detonation of high explosives) represents a major potential trauma source for Servicemembers and Veterans, often resulting in mild traumatic brain injury (mTBI). Executive dysfunction (e.g., alterations memory, deficits mental flexibility, difficulty with adaptability) is commonly reported by Veterans history blast-related mTBI, leading to impaired daily functioning decreased quality life, but underlying mechanisms are not fully understood have been well studied animal...