A5089708269- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Muscle Physiology and Disorders
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Outbreaks Research
- Trypanosoma species research and implications
- Genetics, Aging, and Longevity in Model Organisms
- Parasites and Host Interactions
- Malaria Research and Control
- Heavy metals in environment
- Primate Behavior and Ecology
- Heavy Metal Exposure and Toxicity
- Genomics and Chromatin Dynamics
- Research on Leishmaniasis Studies
- Burkholderia infections and melioidosis
- Insect-Plant Interactions and Control
- Bacterial Genetics and Biotechnology
- Neurogenetic and Muscular Disorders Research
- Fungal and yeast genetics research
- Evolution and Genetic Dynamics
- Insect Resistance and Genetics
- Telomeres, Telomerase, and Senescence
- Gut microbiota and health
United States Army Medical Research Institute of Infectious Diseases
2019-2024
Human Genome Sciences (United States)
2024
Oak Ridge Institute for Science and Education
2018
Yale University
2015-2017
Tulane University
2015
New York University
2013
University of Washington
2006
Mosquitoes, especially Aedes aegypti, are becoming important models for studying invasion biology. We characterized genetic variation at 12 microsatellite loci in 79 populations of Ae. aegypti from 30 countries six continents, and used them to infer historical modern patterns invasion. Our results support the two subspecies formosus as genetically distinct units. outside Africa derived ancestral African monophyletic. The co-occur both East (Kenya) West (Senegal). In rural/forest settings...
Our understanding of the interaction between gut microbiota and host health has recently improved dramatically. However, effects toxic metal exposure on remain poorly characterized. As this creates a critical interface external environment host's cells, it may play an important role in outcomes during exposure. We therefore used 16S ribosomal RNA (rRNA) gene sequencing to track changes composition rats exposed heavy metals. Rats were daily for five days arsenic, cadmium, cobalt, chromium,...
Abstract Aedes albopictus , the “Asian tiger mosquito,” is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during last ~30–40 years. The species of great public health concern as it can transmit at least 26 arboviruses, including dengue, chikungunya, and Zika viruses. In this study, using double‐digest Restriction site‐Associated DNA (dd RAD ) sequencing, we developed a panel ~58,000 single nucleotide polymorphisms ( SNP s) based on 20...
Biological systems produce phenotypes that appear to be robust perturbation by mutations and environmental variation. Prior studies identified genes that, when impaired, reveal previously cryptic genetic This result is typically interpreted as evidence the disrupted gene normally increases robustness mutations, such would allow variants accumulate. However, revelation of variation not necessarily a mutationally state has been made less robust. Demonstrating difference in requires comparing...
The mosquito Aedes aegypti is a vector of yellow fever, dengue, and chikungunya. Control the insect crucial to stop spread dengue chikungunya, so it critically important understand its mating behavior. Primarily, based on laboratory behavior, has long been assumed that Ae. females mate once in their lifetime. However, multiple inseminations have observed semi-field settings, closely related species. Here, we report first evidence polyandry natural population . Female were captured around New...
The trypanosome Trypanosoma brucei gambiense (Tbg) is a cause of human African trypanosomiasis (HAT) endemic to many parts sub-Saharan Africa. disease almost invariably fatal if untreated and there no vaccine, which makes monitoring managing drug resistance highly relevant. A recent study HAT cases from the Democratic Republic Congo reported high incidence relapses in patients treated with melarsoprol. Of 19 Tbg strains isolated enrolled this study, four pairs were obtained same patient...
African trypanosomes of the sub-genus Trypanozoon) are eukaryotic parasitesthat cause disease in either humans or livestock. The development genomic resources can be great use to those interested studying and controlling spread these trypanosomes. Here we present a large comparative analysis Trypanozoon whole genomes, 83 total, including human animal infective trypanosomes: 21 T. brucei brucei, 22 b. gambiense, 35 rhodesiense 4 evansi strains, which were from Uganda. We constructed maximum...
Two clinically important subspecies, Francisella tularensis subsp. (type A) and F. holarctica B) are responsible for most tularaemia cases, but these isolates typically form a weak biofilm under in vitro conditions. Phase variation of the lipopolysaccharide (LPS) has been reported role is unclear as LPS crucial virulence. We previously demonstrated that subpopulation variants can constitutively robust vitro, it whether virulence was affected. In this study, we show biofilm-forming both fully...
Bundibugyo virus (BDBV) is one of four ebolaviruses known to cause disease in humans. (BVD) outbreaks occurred 2007-2008 District, Uganda, and 2012 Isiro, Province Orientale, Democratic Republic the Congo. The BVD outbreak resulted 38 laboratory-confirmed cases human infection, 13 whom died. However, only 4 BDBV specimens from have been sequenced. Here, we provide sequences seven additional patients. Analysis molecular epidemiology evolutionary dynamics with these isolates challenges current...
Purpose. Burkholderia pseudomallei , the tier 1 agent of melioidosis, is a saprophytic microbe that causes endemic infections in tropical regions such as South-East Asia and Northern Australia. It globally distributed, challenging to diagnose treat, infectious by several routes including inhalation, has potential for adversarial use. B. strain MSHR5848 produces two colony variants, smooth (S) rough (R), which exhibit divergent range morphological, biochemical metabolic phenotypes, differ...
Francisella tularensis is one of several biothreat agents for which a licensed vaccine needed to protect against this pathogen. To aid in the development protective pneumonic tularemia, we generated and characterized panel F. isolates that can be used as challenge strains assess efficacy. Our consists both historical contemporary derived from clinical environmental sources, including human, tick, rabbit isolates. Whole genome sequencing was performed genetic diversity comparison reference...
Japanese encephalitis is a disease caused by the virus (JEV) and concern for U.S. military personnel stationed in Republic of Korea (ROK). The recent literature reports potential shift from GI to GV as dominant genotype circulating east Asia. In ROK, has been reported few