To date, high human T-cell lymphotropic virus type I proviral load in patients with I-associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related the pathogenesis of paraparesis. However, cerebrospinal fluid not well investigated. We measured cells from using real-time quantitative polymerase chain reaction (TaqMan). Human were significantly higher than that matched peripheral blood mononuclear cells, a ratio observed short duration illness. Tax-specific...

A retrovirus involvement in the etiology of certain neurological diseases is currently an area intense interest Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little known about cellular immune response. In present study, activated T-lymphocytes were found peripheral blood or patients this disorder. There numbers large CD3-positive...

Journal Article Human T Lymphotropic Virus Type I Infection in Papua New Guinea: High Prevalence among the Hagahai Confirmed by Western Analysis Get access Richard Yanagihara, Yanagihara From Laboratory of Central Nervous System Studies, National Institute Neurological Disorders and Stroke, Institutes Health, Bethesda, Biotech Research Laboratories, Rockville, Maryland, Guinea Medical Research, Goroka Reprints correspondence: Dr. R. Bldg. 36, Rm. 5B-21, MD 20892 . Search for other works this...

Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune-mediated inflammatory disorder of the central nervous system. Immune activation in host, which results from high levels persistent antigenic stimulation and transactivation host immunoregulatory genes by HTLV-I, appears important pathogenesis HAM/TSP. In a single-center, open-label trial, 12 patients with HAM/TSP were treated doses interferon-beta1a up to 60mug twice weekly,...

The neuropathological examination of the spinal cord 2 Jamaican patients with classical tropical spastic paraparesis disclosed an intense chronic meningomyelitis demyelination. In 1 case in which serum and cerebrospinal fluid were available, antibodies to human T-lymphotropic virus type found.

High titers of antibody to human T-lymphotropic virus type I (HTLV-I) have been reported in the sera and cerebrospinal fluids patients with tropical spastic paraparesis. By means agarose isoelectric focusing selective immunoblotting, we demonstrated oligoclonal bands immunoglobulin G antibodies HTLV-I serum fluid Such fluid-specific indicate intrathecal synthesis specific HTLV-I. These findings mimic response measles subacute sclerosing panencephalitis support an etiological role for pathogenesis

We report clinical and laboratory investigations of 47 native-born Jamaican patients with endemic tropical spastic paraparesis 1 patient ataxic neuropathy. Mean age at onset was 40 years, a female-male preponderance (2.7:1). Neurological features are predominantly those variable degrees proprioceptive and/or superficial sensory impairment. Using enzyme-linked immunoabsorbent assay (ELISA), IgG antibodies to human T-lymphotropic virus type I (HTLV-I) were present in 82% sera 77% cerebrospinal...

Human T-lymphotropic virus type I (HTLV-I), the etiological agent of adult T-cell leukemia/lymphoma, also appears to be cause tropical spastic paraparesis, a chronic myelopathy reported in several different regions world. The prevalence antibodies HTLV-I patients with neurodegenerative disorders other than paraparesis and some muscle inflammatory has been investigated. IgG were measured sera and/or cerebrospinal fluid from 82 Guamanian amyotrophic lateral sclerosis parkinsonism-dementia, 164...

Neuropathy with antibodies against myelin-associated glycoproteins (MAG/SGPG-N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination little conduction block. Electrodiagnostic studies suggest that in HMSN1 slowing occurs uniformly along the nerve, whereas MAG/SGPG-N it is predominantly distal. Some but not all previous reports have shown terminal latency index (TLI) was useful to distinguish from idiopathic demyelinating polyneuropathy. We compared...

The clinical syndrome earlier designated as paraparesia espástica del Pacífico is an isolated form of tropical spastic paraparesis (TSP) that was reported in 1981 the southern Pacific lowlands Colombia and near Tumaco. features are similar to those TSP Jamaica, Martinique, Seychelles, Ivory Coast Africa resemble also human T-lymphotropic virus type I (HTLV-I)-associated myelopathy described Japan. Since HTLV-I infection closely associated with TSP, we conducted a case-control study evaluate...

Postmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in meninges patients progressive multiple sclerosis, playing an important role pathophysiology disease. The chemokine (C-X-C motif) ligand 13 (CXCL13) induces formation these organs, thus promoting activity progression to disability sclerosis has been reduced, thanks effect disease modifying therapy. However, despite advances treatment immunomodulatory agents, we still lack specific...

Human T lymphotropic virus type I (HTLV-I) was isolated from peripheral blood- and cerebrospinal fluid-derived mononuclear cells of a 13-y-old boy the blood lymphocytes both his parents. All three had IgG antibodies to HTLV-I varying degrees clinical features tropical spastic paraparesis (TSP). The son also IgM specific for in serum. Isolations were successfully made fluid stimulated with interleukin-2 or cocultivated umbilical cord cells. Established cell lines contained antigen by...

This study presents an analysis of the factors associated with HTLV-I seroprevalence in endemic area Tumaco, Colombia. During June to August 1988, 1,077 individuals were selected at random from a population 45,594. The overall prevalence rate antibodies was 2.8%. Among females significantly higher (p < 0.02) than among males. Rates increased substantially age. history use intravenous medications 0.001) those without such history. Logistic regression included age years, indicators for male...

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid confirmed by Western blot analysis. Multilobulated lymphocytes blood the index case stained monoclonal for T-helper cells T10, an activation marker. mononuclear from HTLV-I–associated myelopathy showed spontaneous proliferation culture, evidence interleukin-2 receptors, decreased natural killer cell activity.

Human T cell lymphotrophic virus type I (HTLV-1) is the etiologic agent of adult lymphoma/leukemia (ATLL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). We studied an HTLV-I-seropositive, white man diagnosed in 1977 with ATLL 10 years later, 6 months prior to his death, TSP/HAM. Sections brain, spinal cord, visceral tissues were examined histologically, immunohistochemically, by situ hybridization, polymerase chain reaction (PCR), PCR amplification a region (pol)...

Summary Background House dust mite allergens have been shown to be a very important stimulus in the causation of asthma and triggers for exacerbation symptoms. Therefore, characterization mite‐derived at molecular level is an step development effective diagnostic therapeutic approaches, as well epidemiological studies. Objective To clone, express characterize cysteine protease from Blomia tropicalis (Bt). Methods A full‐length cDNA encoding Blo t 1 was cloned Bt library using PCR RACE‐based...