Binding information in short-term memory and long-term are functions sensitive to Alzheimer's disease.They have been found be affected patients who meet criteria for familial disease due the mutation E280A of PSEN1 gene.However, only binding has asymptomatic carriers this mutation.The neural correlates dissociation poorly understood.The present study used diffusion tensor MRI investigate whether integrity white matter structures could offer an account.A sample 19 patients, 18 21 non-carrier...

Postmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in meninges patients progressive multiple sclerosis, playing an important role pathophysiology disease. The chemokine (C-X-C motif) ligand 13 (CXCL13) induces formation these organs, thus promoting activity progression to disability sclerosis has been reduced, thanks effect disease modifying therapy. However, despite advances treatment immunomodulatory agents, we still lack specific...

Alzheimer's disease (AD) is the most common cause of dementia; main risk factors are age and several recently identified genes. A major challenge for AD research early detection subjects at risk. The aim this study to develop a predictive model using proton magnetic resonance spectroscopy (1H-MRS), noninvasive technique that evaluates brain chemistry in vivo, monitoring clinical outcome carriers fully penetrant mutation causes AD.We studied 75 from largest multigenerational pedigree world...

Introduction: The primary objective of this study was to determine the diagnostic accuracy and effect an educational training on skin cancer course dermoscopy use among care physicians in rural areas Colombia. secondary assess diagnosis detection rate after 3 months initial training.
 Methods: Twenty-one from 6 Colombia participated a 2-day training, followed by day-long hands-on session at free screening event. Pre- post-tests were performed using clinical dermoscopic images evaluate...

<ns4:p>Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization peripheral immune cells involved in activity disease cascade but their spectrum action intrathecal space brain tissue is limited, taking into consideration persistence oligoclonal bands variation clones lymphoid throughout span. In animal models experimental autoimmune encephalomyelitis (EAE), presence CXCL13 has been associated blockade this chemokine...

Individuals affected with multiple sclerosis (MS) from a genetically homogeneous Caucasian population in Antioquia, tropical region of Colombia, were evaluated order to observe the clinical behavior disease. The frequency manifestations 65 patients definite MS Antioquia was compared those reported temperate regions. most common optic neuritis and motor symptoms absence cerebellar symptoms. This presentation is significantly different distribution at onset series These differences suggest...

<ns4:p>Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization peripheral immune cells involved in activity disease cascade but their spectrum action intrathecal space brain tissue is limited, taking into consideration persistence oligoclonal bands variation clones lymphoid throughout span. In animal models experimental autoimmune encephalomyelitis (EAE), presence CXCL13 has been associated blockade this chemokine...

<ns4:p>Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization peripheral immune cells involved in activity disease cascade. However, their spectrum action intrathecal space brain tissue is limited, taking into consideration persistence oligoclonal bands variation clones lymphoid throughout span. In animal models experimental autoimmune encephalomyelitis, a blockage CXCL13 has resulted modification course it could...

Diagnostic uncertainty may arise in patients with occipitoparietal epilepsy when there is neuroimaging evidence of a posterior quadrant lesion and coexistent hippocampal abnormalities ("dual pathology"). It not known whether atrophy (HA) these results from seizure propagation to temporolimbic structures or it part the pathological process underlying epilepsy. Clarification this issue have significant bearing on management patients.We studied 20 pathologic congenital developmental...

ABSTRACT The authors investigate the reproducibility of metabolite signals measured with proton magnetic resonance spectroscopy 1 H‐MRS) acquired from human hippocampus in controls and a phantom. Two H‐MRS studies separated by 3 weeks were performed 8 healthy volunteers N‐acetyl compounds (NA), choline (Ch), creatine (Cr) peak areas ratios compared using percentage variation, Pearson Correlation Coefficient at level every voxel, (5 voxels), 2 hippocampi (10 voxels). Sensitivity for observing...

Studies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and major histocompatibility complex (MHC). We present results of a case-control study conducted on tropical population (Antioquia, Colombia) order to detect possible MS HLA DQalpha (HLA DQA1*) alleles. Forty chromosomes belonging patients were compared two sets controls (40 910 chromosomes, respectively). The DQA1*0101 DQA1*0102 alleles significantly higher...

Interictal proton (1H) MRS is increasingly used for seizure lateralization in patients with temporal lobe epilepsy (TLE). Studies reporting postictal 1H-MRS metabolite changes TLE are few and contradictory. The authors prospectively performed interictal magnetic resonance spectroscopy imaging (1H-MRSI) studies seven TLE. found no consistent peak area ratios between studies, suggesting that remain stable state

<ns4:p>Although no evidence of disease activity (NEDA) permits evaluation response to treatment in the systematic follow-up patients with multiple sclerosis (MS), its ability accomplish detection surreptitious is limited, thus being unable prevent from falling into a non-reversible progressive phase disease. A protocol based on use validated biomarkers that conducted at an early stage would permit capture abnormal neuroimmunological phenomena and lead towards intervention modifying therapy...

Although no evidence of disease activity (NEDA) permits evaluation response to treatment in the systematic follow-up patients with multiple sclerosis (MS), its ability accomplish detection surreptitious is limited, thus being unable prevent from falling into a non-reversible progressive phase disease. A protocol based on use validated biomarkers that conducted at an early stage would permit capture abnormal neuroimmunological phenomena and lead towards intervention modifying therapy before...

Despite the current availability of disease modifying therapies for treatment multiple sclerosis, there are still patients who suffer from severe neurological dysfunction in relapsing-remitting or early progressive forms disease. For these autologous hematopoietic stem cell transplant offers an important therapeutic solution to prevent progression irreversible disability. In spite studies last two decades, patient inclusion criteria, protocols peripheral blood mobilization and bone marrow...

Discrimination and quantification of the environmental genetic components involved in developing multiple sclerosis (MS) have not been made. In order to discriminate these we ascertained affected individuals by MS belonging Paisa community from Antioquia, Colombia, a state localized tropical area South America, detect eventual linkage disequilibrium HLA, locus DQ alpha, which could demonstrate relevance component.A contingence analysis among case-control HLA alpha genotype distributions,...

Resumen Antecedentes: la neuritis óptica es inflamación del nervio óptico y su etiología puede ser infecciosa, vasculítica, parainfecciosa/autoinmune o manifestación de un trastorno desmielinizante. Se caracteriza por pérdida agudeza visual aguda, dolor al realizar movimientos oculares capacidad reducida para percepción color. En niños el pico presentación entre los 9-11 años incidencia anual estimada en población pediátrica 0.2 100.000 niños. Reporte caso: este reporte caso hablaremos una...