A5065448989- Suicide and Self-Harm Studies
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Resilience and Mental Health
- COVID-19 and Mental Health
- Family Dynamics and Relationships
- Social and Intergroup Psychology
- Psychological Well-being and Life Satisfaction
- Cultural Differences and Values
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Disability Support Research
- Attachment and Relationship Dynamics
- Mental Health Treatment and Access
- Gender, Labor, and Family Dynamics
- Psychosomatic Disorders and Their Treatments
- Intergenerational Family Dynamics and Caregiving
- Early Childhood Education and Development
- Child Welfare and Adoption
- Migraine and Headache Studies
- Racial and Ethnic Identity Research
- Work-Family Balance Challenges
- Youth Substance Use and School Attendance
- Personality Disorders and Psychopathology
University of Cambridge
2017-2025
Addenbrooke's Hospital
2018-2024
University College Dublin
2011-2021
Tavistock Institute
2018-2020
Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional connectomes into compact manifold spaces, identified marked expansion connectomes, with strongest effects transmodal regions during adolescence. Findings reflected increased within-module connectivity together segregation, indicating increasing differentiation...
Adolescence is a time of profound changes in the physical wiring and function brain. Here, we analyzed structural functional brain network development an accelerated longitudinal cohort spanning 14 to 25 y ( n = 199). Core our work was advanced vivo model cortical incorporating MRI features corticocortical proximity, microstructural similarity, white matter tractography. Longitudinal analyses assessing age-related identified continued differentiation multiple networks youth. We then assessed...
Incidence of depression increases markedly around age 13 years, and nearly three-quarters adults report that their mental health problems started in adolescence. Although maternal is a risk factor for adolescent depression, evidence about the association between paternal inconclusive, many studies have methodological limitations. We aimed to assess depressive symptoms two large population-based cohort studies.We used data two-parent families from representative prospective cohorts Ireland...
Abstract Few studies assessing the effects of COVID-19 on mental health include prospective markers risk and resilience necessary to understand mitigate combined impacts pandemic, lockdowns, other societal responses. This population-based study young adults includes individuals from Neuroscience in Psychiatry Network ( n = 2403) recruited English primary care services schools 2012–2013 when aged 14–24. Participants were followed up three times thereafter, most recently during initial...
Values and beliefs (or social axioms) are important personality constructs, but little previous work has examined the relationship between two, none their real–life longitudinal effects on one another. Major life transitions—such as moving to a new culture—can challenge existing values therefore provide particularly useful context for analysis of value belief change. The main aim this research was examine whether may predict theoretically meaningful change vice versa. Polish migrants...
Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence typical atypical adult cognitive emotional processes. We analysed multimodal magnetic resonance imaging (MRI) data collected from N <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"> <mml:mo>∼</mml:mo> </mml:math> 300 healthy adolescents (51%; female; 14 26 y) each scanned repeatedly in an accelerated longitudinal design,...
Compulsive behavior is enacted under a belief that specific act controls the likelihood of an undesired future event. behaviors are widespread in general population despite having no causal relationship with events they aspire to influence. In current study, we tested whether there increased tendency assign value aspects task do not predict outcome (i.e., outcome-irrelevant learning) among individuals compulsive tendencies. We studied 514 healthy who completed self-report compulsivity,...
We used a probabilistic reversal learning task to examine prediction error-driven belief updating in three clinical groups with psychosis or psychosis-like symptoms. Study 1 compared people at-risk mental state and first episode (FEP) matched controls. 2 diagnosed treatment-resistant schizophrenia (TRS) The design replicated our previous work showing ketamine-related perturbations how meta-level confidence maintained behavioural policy. applied the same computational modelling analysis here,...
Objectives To inform suicide prevention policies and responses to youths at risk by investigating whether is predicted a summary measure of common mental distress (CMD (the p factor)) as well conventional psychopathological domains; define the distribution risks over population range CMD; test such mediates medium-term persistence risks. Design Two independent population-based cohorts. Setting Population based in two UK centres. Participants Volunteers aged 14–24 years recruited from primary...
Personality with stable behavioural traits emerges in the adolescent and young adult years. Models of putatively distinct, but correlated, personality have been developed to describe styles including schizotypal, narcissistic, callous-unemotional, negative emotionality, antisocial impulsivity traits. These influenced classification their related disorders. We tested if a bifactor model fits data better than correlated-factor orthogonal-factor models subsequently validated obtained factors...
The VinelandTM Adaptive Behavior Scale is often used in autism spectrum disorder (ASD) trials. Composite Score (VABS-ABC) the standardized overall score (the average of Socialization, Communication and Daily Living skills domains), 2-Domain (VABS-2DC) a novel outcome measure (average Socialization domains). A within-person meaningful change threshold (MCT) has not been established for VABS-2DC. This paper presents quantitative qualitative interpretation what constitutes these scores to...
Abstract Purpose Psychometric evaluation of the Nocturia Impact (NI) Diary was conducted to support its use as a trial endpoint. Methods As part randomized, controlled Phase 2 clinical investigating novel drug candidate for nocturnal polyuria, adult nocturia patients completed NI and voiding diary three nights preceding their clinic visit at Baseline Weeks 1, 4, 8, 12 (end treatment). Exit interviews were obtain patient impressions Diary. Results A total N = 302 participants included....
This paper evaluated the evidence supporting factor structure of extant coping instruments based on modern psychometric standards. Our literature search identified nine that are routinely used to measure strategies in adult populations. While nearly 10 thousand papers have been published using these instruments, only 39 studies investigated their validity. findings revealed majority did not follow current recommendations for establishing internal validity part because they account ordinal...
This article reports on a preliminary test of the effectiveness Adopting Together, time-limited psychodynamic couple-focused therapy model for adoptive couples. Fifty-one couples approached programme and 50 were offered (40 heterosexual, six lesbian four gay male couples). The intervention took place in Cohort 1 between June December 2015, 2 October 2016 April 2018. Data collected at intake (T1), after 10 weeks (T2) completion 20 (T3). Participants’ scores these time points compared using...
This study examined the effect of work-hours constraint, i.e., discrepancy in women's actual and ideal hours worked, on couple's mental health (depression symptoms assessed with a questionnaire) relationship satisfaction.Irish dual-earner couples (N=3,928), participants large cohort Growing Up Ireland, were assigned to three groups based constraint: overemployed, underemployed adequately employed.Group comparison carried out MANCOVA indicated that employed women had lower depression than...
Background: Recent evidence suggests that multiple symptoms or diagnoses, partucularly when co-ocuring with non-suicidal self-harm, predict suicide risk more strongly than single diagnosis.