A5040257114- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- TGF-β signaling in diseases
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
Tohoku University
2015-2023
Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play a critical role in host defence, although the of PGE2 , bioactive substance generated inflammatory tissues, formation remains unclear.The effects agonists antagonists its receptors, modulators cAMP-PKA pathway on were examined vitro isolated vivo newly established mouse model.PGE2 inhibited...
Abstract Ribosome biogenesis is essential for maintaining basic cellular activities although its mechanism not fully understood. Inhibitor of growth 4 (ING4) a member ING family while functions remain controversial. Here, we identified several nucleolar proteins as novel ING4 interacting proteins. localized in the nucleus with strong accumulation nucleolus through plant homeodomain, which known to interact histone trimethylated H3K4, commonly present promoter active genes. deficient cells...
Pancreatic ductal adenocarcinoma (PDAC), caused by activating mutations in K-Ras, is an aggressive malignancy due to its early invasion and metastasis. Ral GTPases are activated downstream of Ras play a crucial role the development progression PDAC. However, underlying mechanisms remain unclear. In this study, we investigated mechanism Ral-induced metastasis PDAC cells using RalGAPβ-deficient with highly GTPases. Array analysis ELISA revealed increased expression secretion TGF-β1 compared...