A5026314377- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Zebrafish Biomedical Research Applications
- Cancer-related Molecular Pathways
- Renal and related cancers
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Advanced Radiotherapy Techniques
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- TGF-β signaling in diseases
- Adrenal and Paraganglionic Tumors
- Cytokine Signaling Pathways and Interactions
- Renal cell carcinoma treatment
- Cervical Cancer and HPV Research
Sichuan University
2013-2023
State Key Laboratory of Oral Diseases
2019-2023
Tohoku University
2021-2023
Tianjin Medical University
2023
Sun Yat-sen University
2018-2022
The First Affiliated Hospital, Sun Yat-sen University
2022
University of California, Los Angeles
2018
Ganzhou People's Hospital
2018
Second Hospital of Shandong University
2018
Abstract Objectives To investigate the role of hypoxia in vasculogenic mimicry (VM) salivary adenoid cystic carcinoma (SACC) and underlying mechanism involved. Materials methods Firstly, wound healing, transwell invasion, immunofluorescence tube formation assays were performed to measure effect on migration, EMT VM SACC cells, respectively. Then, RT‐PCR used detect VE‐cadherin VEGFA expression. And pro‐vasculogenic was investigated by confocal laser scanning microscopy Western blot....
The tumor-related myeloid derived suppressor cells (MDSCs), important immunosuppressive in tumor microenvironment, play an role the cancer progression. This study is aimed to investigate crosstalk between MDSCs and oral squamous cell carcinoma (OSCC) their malignant progression of OSCC.Immunochemistry (IHC) was used expression CD33 200 OSCC, 36 premalignant. CD33+ were sorted enriched via magnetic-activated sorting (MACS) from OSCC patients or health donor, phenotypes identified by flow...
Abstract The enhancer of zeste homolog 2 (EZH2), known as a member the polycomb group (PcG) proteins, is an oncogene overexpressed in variety human cancers. Here, we found that EZH2 correlated with poor survival oral squamous cell carcinoma (OSCC) patients using immunohistochemistry staining. overexpression led to significant induction tumour glycolysis, Epithelial‐mesenchymal transition (EMT), migration and invasion OSCC cells. Conversely, silencing inhibited EMT, Ectopic increased...
Cathepsin B (CTSB) has been reported to be involved in cancer metastasis by altering extracellular matrix (ECM) remodeling and facilitating invasion. However, the contribution of CTSB collective cell invasion salivary adenoid cystic carcinoma (SACC) underlying mechanisms remain unclear. The present study demonstrated that is commonly observed SACC without a complete epithelial‑mesenchymal transition signature. was found overexpressed invasive front compared tumor center, associated with poor...
Long non-coding RNAs (lncRNAs) are attracting more and attention from researchers because they relatively new factors in regulating biological processes human cancers. The Colorectal Neoplasia Differentially Expressed (CRNDE) lncRNA is transcribed chromosome 16 on the opposite strand to neighboring IRX5 gene. It was originally discovered abnormally expressed colorectal cancer (CRC) certified a critical biomarker many However, its function mechanism underlying tumorigenesis of cervical still...
Signal transducer and activator of transcription 3 (STAT3), a previously accepted tumor-promoting protein in various malignancies, plays key role the process cancer glycolysis. However, potential mechanism STAT3 aerobic glycolysis progression oral squamous cell carcinoma (OSCC) has not been explored. In present study, we demonstrated that knockdown remarkably inhibited migration, invasion, expressions epithelial-mesenchymal transition (EMT) markers, OSCC cells by up-regulation FoxO1....
Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage, while better prognosis. microRNAs (miRNAs) has been shown to play a critical role in cancer, however, their HPV-positive OSCC progression remains unclear.miRNA microarray was performed identify differentially expressed miRNAs. qRT-PCR FISH were determine the relative expression of miR-550a-3-5p. CCK-8, Flow cytometry, Wound healing, Cell invasion assays...
Since their discovery in the 1990’s, microRNAs (miRNA) have opened up new vistas field of cancer biology and are found to fundamental roles tumorigenesis progression. As head neck squamous cell carcinoma (HNSCC) with positive human papillomavirus (HPV+) is significantly distinct from its HPV negative (HPV−) counterpart terms both molecular mechanisms clinical prognosis, current study aimed separately develop miRNA signatures for HPV+ HPV− HNSCC as well explore potential functions. Both were...
The small GTPases RalA and RalB are members of the Ras family activated downstream Ras. Ral proteins found in GTP-bound active GDP-bound inactive forms. activation process is executed by guanine nucleotide exchange factors, while inactivation mediated GTPase-activating (GAPs). RalGAPs complexes that consist a catalytic α1 or α2 subunit together with common β subunit. Several reports implicate importance pancreatic ductal adenocarcinoma (PDAC). However, there few on relationship between...
The activation of CXCL12/CXCR4 axis participated in the progression multiple cancers, but potential effect terms perineural invasion (PNI) SACC remained ambiguous. In this study, we identified that CXCL12 substantially expressed nerve cells. CXCR4 strikingly tumour cells, and expression was closely associated with level EMT-associated proteins Schwann cell hallmarks at frontier SACC. Activation could promote PNI up-regulate relative genes EMT both vitro vivo, which be inhibited by Twist...
Pancreatic ductal adenocarcinoma (PDAC), caused by activating mutations in K-Ras, is an aggressive malignancy due to its early invasion and metastasis. Ral GTPases are activated downstream of Ras play a crucial role the development progression PDAC. However, underlying mechanisms remain unclear. In this study, we investigated mechanism Ral-induced metastasis PDAC cells using RalGAPβ-deficient with highly GTPases. Array analysis ELISA revealed increased expression secretion TGF-β1 compared...
Clear cell sarcoma of the kidney (CCSK) in adults is extremely rare. In fact, only 16 adult CCSK cases have been reported from 1989 to 2020 English language literature. The pathologic diagnosis disease difficult, and optimal treatment still unknown. Currently, no literature review has done on patients. Herein, we report case a 24-year-old man who presented with right flank pain for one month. patient underwent series diagnostic tests, imaging examinations revealed large mass his kidney....
<title>Abstract</title> Background: Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage, while better prognosis. microRNAs (miRNAs) has been shown to play a critical role in cancer, however, their HPV-positive OSCC progression remains unclear.Methods: miRNA microarray was performed identify differentially expressed miRNAs. qRT-PCR FISH were determine the relative expression of miR-550a-3-5p. CCK-8, Flow...
Bevacizumab has gradually become an important adjuvant therapy for many advanced tumors including lung cancer. Although it can improve the survival of cancer patients, also brings adverse reactions, fistula formation. However, vesicovaginal in absence pelvic lesions and radiation history not been reported before.We diagnosed non-small cell patient with left pleural, bone liver metastases February 2017. She then received Gefitinib-targeted therapy. Ten months later, achieved complete...
<title>Abstract</title> <bold>Background: </bold>Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage. Studies suggested that microRNAs (miRNAs) play a critical role in cancer; However, their HPV-positive OSCC progression remains unclear.<bold>Methods: </bold>miRNA microarray was performed to identify differentially expressed miRNAs. qRT-PCR FISH were determine the relative expression of miR-550a-3-5p. CCK-8,...
The energy levels, transition energies, rates and oscillator strength are calculated for the 1s2,1s2s 2s2p configurations of 51 He-like ions ( [[EQUATION]] ) by using Multi-Configuration Dirac-Hartree-Fock (MCDHF) method relativistic configuration interaction (RCI) method. Grasp2K package based on MCDHF is applied to carry out a systematic computation including complex electron correlation effects efficiently with aid active space A parallel calculation Flexible Atomic Code (FAC) used...