A5101640507- Probiotics and Fermented Foods
- Gut microbiota and health
- Selenium in Biological Systems
- Trace Elements in Health
- Microbial Metabolites in Food Biotechnology
- Polyamine Metabolism and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Amino Acid Enzymes and Metabolism
- Pancreatitis Pathology and Treatment
- Infant Nutrition and Health
- Enzyme Production and Characterization
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Neurological diseases and metabolism
- Heavy Metal Exposure and Toxicity
- Therapeutic Uses of Natural Elements
- Clostridium difficile and Clostridium perfringens research
- Medical and Biological Ozone Research
- Thallium and Germanium Studies
State Key Laboratory of Food Science and Technology
2018-2024
Jiangnan University
2018-2024
Variations in selenium (Se) intake have been reported to affect the barrier function and immune responses gut. Previous studies mainly focused on role of Se itself or its metabolites, while influences Se-intake-related microbiota gut health were not thoroughly studied. This study compared effects different dietary supplementation (Se-deficient, Se-adequate, Se-supranutritional) mice. Fecal transplantation (FMT) was further conducted bypass effect provided direct evidence that intestinal are...
The heavy metal cadmium (Cd) is a contaminant widely distributed in the food chain. In present study, 8-week oral administration of probiotic strain, Lactobacillus plantarum CCFM8610, markedly decreased blood Cd levels volunteers. Further animal study showed that three L. strains administered orally exhibited significantly different effects on regulation bile acid (BA) metabolism and excretion mice. Among strains, CCFM8610 most significant enhancing hepatic BA synthesis, biliary glutathione...
Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology perturbed the fecal metabolic profiles jejunal protein expression in mice.
Abstract The pathogenesis of Parkinson's disease (PD) is closely related to the gut microbiota, and microecological therapies based on probiotics have received widespread attention, among which Bifidobacterium has been demonstrated a potential neuroprotective effect, but specific mechanisms lacking in investigation. Here, we show that longum subsp. CCFM1029 significantly inhibited LPS‐induced inflammatory responses microglia alleviated 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine...
Abstract Prevotella copri , which is divided into four clades, exerts bidirectional effects on host health. These include positive improvements in the allergy response and insulin sensitivity. However, P. sometimes has adverse health, it been found to be positively correlated with inflammation, resistance, diarrhea. The interaction between these diseases influenced by host's diet. capacity of metabolize dietary glycans, as well its degradation products, such short‐chain fatty acids succinic...
Abstract Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence bone‐related diseases, significantly compromising individuals’ quality life. The gut microbiota actively participates in regulation metabolism, and perturbations can exacerbate diseases by barrier integrity. Determining microbial taxa involved loss could offer valuable insights into development alternative therapies nutritional interventions for disease management. Therefore, based on...
Selenium, one of the essential trace elements in humans and animals, is involved various biochemical physiological functions, such as improving immunity antioxidant properties. Lactic acid bacteria, recognized generally safe (GRAS) world, have ability to convert inorganic selenium into organic form plenty outstanding probiotic properties, including regulation gut microbiota, increase capacity, decrease intestinal inflammation so on. Therefore, using them a efficient supplementation carrier...