A5013196429- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- DNA and Nucleic Acid Chemistry
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- biodegradable polymer synthesis and properties
- Nuclear physics research studies
- Advancements in Transdermal Drug Delivery
- Quantum Chromodynamics and Particle Interactions
- Supramolecular Self-Assembly in Materials
- Pickering emulsions and particle stabilization
- Biopolymer Synthesis and Applications
- Polymer Nanocomposites and Properties
- Electrostatics and Colloid Interactions
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Curcumin's Biomedical Applications
- High-Energy Particle Collisions Research
- Synthesis and properties of polymers
- Block Copolymer Self-Assembly
Bulgarian Academy of Sciences
2015-2024
Institute of Polymers
2015-2024
University of Chemical Technology and Metallurgy
2006-2014
Institute of Macromolecular Compounds
2009
University of Bath
2008
Polish Academy of Sciences
2004-2007
Centre of Polymer and Carbon Materials
2007
Uppsala University
2000-2004
Royal Swedish Academy of Sciences
2004
Eight well-defined poly(glycidol)−poly(propylene oxide)−poly(glycidol) (PG−PPO−PG) block copolymers with PG contents from 20 to 84 wt % and fixed molecular weight of the middle PPO 2000 were prepared. The are considered as analogues commercially available Pluronic, poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) (PEO−PPO−PEO), in which PEO blocks substituted by linear PG. They prepared means anionic polymerization ethoxyethyl glycidyl ether (protected glycidol) followed...
The current study describes the elaboration of a hybrid drug delivery platform for an intravesical application based on curcumin/gentamicin sulfate simultaneously loaded niosomes incorporated into thermosensitive in situ gels. Series were elaborated via thin film hydration method, evaluating impact non-ionic surfactants', cholesterol's, and curcumin's concentration. formulation composed equimolar ratio Span 60, Tween 30 mol% cholesterol was selected as optimal composition, due to high...
Abstract The synthesis and aggregation behavior of well‐defined thermosensitive (co)polymers oligo(ethylene glycol) methacrylates (POEGMA) in aqueous solutions were investigated. cloud points the POEGMAs determined by turbidimetry dynamic light scattering. For POEGMA point temperature ( T CP ) increased linearly with increasing content more hydrophilic comonomer. mesoglobules formed dilute above studied size depended on concentration heating procedures. aggregates became smaller decreasing...
Random copolymers of n-propyl-2-oxazoline and ethylenimine (PPrOx–PEI) were prepared by partial acidic hydrolysis poly(n-propyl-2-oxazoline) (PPrOx). Dynamic electrophoretic light scattering diffusion-ordered NMR spectroscopy utilized to investigate aqueous solution properties the copolymers. Above a specific cloud point temperature, well-defined nanoparticles formed. The latter consisted core composed predominantly PPrOx thin positively charged shell from PEI moieties that mediated...
A number of ABA and BAB triblock copolymers ethoxyethyl glycidyl ether (EEGE) propylene oxide (PO) were prepared by sequential anionic polymerization. The characterized nuclear magnetic resonance gel permeation chromatography. total number-average molecular weights in the range 1000−9000, whereas degrees polymerization PPO PEEGE blocks varied from 2 to 34 3 17, respectively. comprised with different lower critical solution temperatures (LCSTs) aqueous media. Their self-association...
In this work we focus on the use of novel homo and block copolymers based poly(vinyl benzyl trimethylammonium chloride) as gene delivery vectors. The homopolymers were synthesized by RAFT polymerization schemes molecularly characterized. DNA/polymer complexes (polyplexes) in a wide range N/P (amino-to-phosphate groups) ratios prepared. ability polymers to form with linear DNA was investigated light scattering, zeta potential, ethidium bromide fluorescence quenching measurements. resulting...
Oxazolines and the mechanism of their polymerization have been known for over 40 years. The relatively easy control process oxazolines, wide range oxazoline polymer properties, reaching from strongly hydrophilic through amphiphilic, temperature responding to hydrophobic last not least high biocompatibility cause that these polymers are intensively studied interest them seem increase. In this paper cationic polyoxazolines, especially problem reversible desactivation reactivation active...
Abstract Poly(2‐methyl‐2‐oxazoline)‐polyethylenimine (PMeOx‐co‐PEI) copolymers differing by degree of polymerization (DP = 50 and 200) PEI content (from 37 to 99 mol%) were synthesized living cationic ring‐opening 2‐methyl‐2‐oxazoline, followed partial hydrolysis. Upon mixing with DNA in a wide range N/P ratios, they formed well‐defined polyplex particles small size (typically below 100 nm) narrow distribution. The polyplexes demonstrated good colloidal stability very low vitro cytotoxicity....
We report on a method for the encapsulation of DNA into polymeric nanocapsules. The procedure involves three steps: formation polyplexes between and cationic micelles; coating with cross-linked shell; dissociation polyplexes. In first step copolymer micelles were obtained by self-assembly an amphiphilic polystyrene-b-poly(quaternized 2-vinylpyridine) (PS-b-PQ2VP) block in aqueous solution. Nanosized (Dh = 190 nm ζ −21 mV) formed upon addition to micellar solution at phosphate/amine group...
This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on aggregation thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene methacrylate) is synthesized by AGET ATRP using modified as macroinitiator. The abrupt heating water solution leads self-assembly chains and formation mesoglobules controlled sizes. Mesoglobules formed bioconjugates are stabilized...
Abstract Physicochemical characteristics and biological performance of polyplexes based on two identical copolymers bearing tertiary amino or quaternary ammonium groups are evaluated compared. Poly(2‐(dimethylamino)ethyl methacrylate)‐ b ‐poly(oligo(ethylene glycol) methyl ether methacrylate) block copolymer (PDMAEMA‐ ‐POEGMA) is synthesized by reversible addition fragmentation chain transfer polymerization. The amines PDMAEMA converted to quaternization with iodide. spontaneously formed...
Six high molar mass polyglycidol samples were obtained by fractionation of synthesized means cationic polymerization ethoxyethyl glycidyl ether followed cleavage the protective groups. The fractions covering range from 0.1 to 2.4 × 106 studied dynamic and static light scattering. weight-average masses (Mw), second virial coefficients (A2), radii gyration (Rg), diffusion (D0), hydrodynamic (Rh), (kDφ) determined for single coil in dilute aqueous solution at 25 °C, scaling equations...
Abstract This study describes the synthesis and aggregation behavior of thermosensitive poly(di(ethylene glycol) monomethyl ether methacrylate) (P(DEGMA‐ME)) conjugated with fluorescently labeled pentapeptide glycine‐arginine‐lysine‐phenylalanine‐glycine‐dansyl (GRKFG‐Dns). The GRKFG‐Dns was obtained using Fmoc solid‐phase peptide modified 2‐bromopropionic acid to initiate an atom transfer radical polymerization di(ethylene methacrylate (DEGMA‐ME). led a well‐defined P(DEGMA‐ME)–GRKFG‐Dns...