A5032964805- Lipoproteins and Cardiovascular Health
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Circular RNAs in diseases
- Biomarkers in Disease Mechanisms
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Cardiac Arrhythmias and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Cardiomyopathy and Myosin Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Intracranial Aneurysms: Treatment and Complications
- Computational Drug Discovery Methods
- Advanced X-ray and CT Imaging
- Nuclear Receptors and Signaling
Riga Stradiņš University
2015-2024
Pauls Stradiņš Clinical University Hospital
2019-2024
University of Latvia
2022
Abstract Background/Introduction Near-infrared spectroscopy (NIRS) allows to quantify lipid composition of coronary artery lesions. High plaque content has been associated with increased adverse cardiovascular event risk. Purpose Aim this study was evaluate atherosclerotic reduction in association low-density lipoprotein (LDL-C) lowering on the background intensive hypolipidaemic therapy. Methods NIRS investigation performed stable disease patients having 20-50% stenosis proximal or middle...
Abstract Background Low-density lipoprotein cholesterol (LDL-C) has a causal role in atherosclerotic cardiovascular disease. Genetic studies and variability individual response to lipid-lowering therapies suggest combining hypolipidaemic medications with different mechanisms of action. Purpose The aim this study was evaluate the effect triple inclisiran-based therapy patients not reaching LDL-C target on maximum statin/ezetimibe treatment. Methods This prospective enrolled 37 stable coronary...
Plasma circulating microRNA (miRNA)-126, -145, and -155 are associated with vascular remodeling, atherosclerotic lesion formation, plaque vulnerability. In this study, we evaluated the levels of plasma miRNAs in patients stable coronary artery disease (CAD), different cardiovascular risk profiles, glomerular filtration rates (GFR).
Aims: Circulating microRNAs (miRNAs) have been identified as biomarkers for several diseases.Dysregulation of miRNA-126, microRNA-145, and microRNA-155 has shown to be associated with atherosclerotic lesion formation.The aim this study was evaluate the association between atherosclerosis-related miRNAs unfavorable plaque characteristics.Methods Results: Forty patients stable coronary artery disease admitted elective percutaneous intervention (PCI) were enrolled in a prospective study.After...
Kontext: U pacientů s fibrilací síní se k obnově sinusového rytmu běžně provádí elektrická kardioverze. Dlouhodobé hodnoty incidence klinických příhod a udržení po elektrické kardioverzi však nejsou přesně známy. Tato monocentrická studie zkoumala jednoroční incidenci rizikové faktory vzniku kardiovaskulárních recidivy fibrilace síní.Metody: Do prospektivní bylo zařazeno 188 síní, u nichž byla provedena V následném jednoročním sledování, jehož zúčastnili pacienti jejich praktičtí lékaři,...
Úvod: Fibrilace síní (FS) je celosvětově nejčastější formou arytmie, která postihuje přibližně 33 milionů jedinců. Antikoagulanciem volby v prevenci cévní mozkové příhody u jedinců s FS již dlouho warfarin. Několik velkých studií prokázalo, že nová (přímá) perorální antikoagulancia (non-vitamin K antagonist oral anticoagulant, NOAC) mají z hlediska bezpečnosti a účinnosti řadu předností, jako například fixní dávku předvídatelnější farmakokinetiku. Metody: Naše studie, provedená lotyšském...
Kontext: Implantace stentů do karotických tepen (carotid artery stenting, CAS) se v současnosti ve velkém měřítku používá léčbě stenózy tepen. Klinické studie z poslední doby prokázaly nízkou incidenci příhod po CAS. Tato hodnotí 30denní a roční výsledky pacientů léčených pro CAS intenzivní farmakoterapií na pracovišti provádějícím vysoké počty perkutánních koronárních intervencí ročně.Metoda: V období od ledna 2011 prosince 2013 byla provedena celkem u 184 pacientů. Mimo protidestičkové...
Abstract Background/Introduction The benefits of lipid-lowering drug treatment for the secondary prevention coronary heart disease have been well-established by randomized, controlled trials. More evidence has now emerged to support use high-intensity low-density lipoprotein cholesterol (LDL-C) –lowering therapy including statine, ezetimibe, and PCSK9 inhibitors. Intravascular imaging, such as near-infrared spectroscopy (NIRS) can detect lipid-rich plaques. Virtual histology...
Objective: In patients with stable coronary artery disease left ventricular ejection fraction may remain within normal range. Myocardial strain is a precise tool for evaluation of early subclinical systolic function changes in number cardiac pathologies. Our aim was to determine if there correlation between global longitudinal (GLS) and complexity disease. Design method: Study included (SCAD) undergoing elective percutaneous intervention (PCI). Patients PCI previous 3 months or target...