A5059868628- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Hip and Femur Fractures
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Pelvic and Acetabular Injuries
- Intensive Care Unit Cognitive Disorders
- Hematological disorders and diagnostics
- Bone Tumor Diagnosis and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone Metabolism and Diseases
- Musculoskeletal synovial abnormalities and treatments
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
Huashan Hospital
2016-2025
Fudan University
2016-2025
Osteoarthritis (OA) is the most common degenerative disease of joint with irreversible cartilage damage as main pathological feature. With development regenerative medicine, mesenchymal stem cells (MSCs) have been found to strong therapeutic potential. However, intraarticular MSCs injection therapy limited by economic costs and ethics. Exosomes derived from MSC (MSC-Exos), important intercellular communication mode MSCs, contain nucleic acid, proteins, lipids, microRNAs, other biologically...
Osteoarthritis (OA) progression is highly associated with chondrocyte mitochondrial dysfunction and disorders of catabolism anabolism the extracellular matrix (ECM) in articular cartilage. The unfolded protein response (UPRmt), which an integral component quality control (MQC) system, essential for maintaining homeostasis. We successfully validated pivotal role activating transcription factor 5 (ATF5) upregulating UPRmt, mitigating IL-1β-induced inflammation dysfunction, promoting balanced...
Abstract Introduction Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention the major obstacle to establishment of this as preferred route delivery. Here, we explored whether magnetic targeting could enhance retrograde in rat model myocardial infarction. Methods Rat mesenchymal stem cells were labeled with superparamagnetic oxide nanoparticles. The responsiveness MSCs was observed while flowed through tube that served blood...
Abstract Background Several studies have been conducted to report diagnostic values of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and lymphocyte-to-monocyte (LMR) in many diseases, such as oncological, inflammatory, some infectious diseases. However, predictive value these laboratory parameters for early periprosthetic joint infections (PJIs) has not yet reported. The aim this study was determine postoperative NLR, PLR, LMR diagnosis PJIs. Methods In...
Abstract Objective This study was aimed to utilize a modified anterior drawer test (MADT) detect the cruciate ligament (ACL) ruptures and investigate its accuracy compares with three traditional tests. Methods Four hundred patients were prospectively enrolled between January 2015 September 2017 preoperatively undergo knee arthroscopic surgeries. The MADT, test, Lachman pivot shift used in outpatient clinical setting compared statistically for their terms of ACL ruptures, findings as gold...
This study was aimed to investigate whether the application of platelet-rich plasma (PRP) combined with β-tri-calcium phosphate (β-TCP) grafts after core decompression (CD) could improve clinical outcomes early stage avascular necrosis femoral head.Forty-five (54 hips) patients Ficat-Arlet classification I-II treated by CD β-TCP or without PRP from July 2015 October 2020 were reviewed. Group A (CD + grafts) included 24 (29 hips), while group B PRP) 21 (25 hips). Visual analogue scale (VAS)...
Osteoarthritis (OA) is a cartilage-degenerative joint disease. Mitophagy impacts articular cartilage damage. tRNA-derived small RNAs (tsRNAs) are one of the contents adipose mesenchymal stem cell (AMSC)-derived exosomes (AMSC-exos) and involved in disease progression. However, whether tsRNAs regulate mitophagy tsRNA-modified AMSC-exos improve OA via remain unclear. We performed RNA sequencing to identify OA-related tsRNAs, which were then loaded into AMSC-exos, exploring function mechanisms...
The study is aimed at investigating the association between different reduction classifications (anatomic reduction, positive buttress position and negative reduction) two end points (complications reoperations).The retrospectively analyzed 110 patients undergoing internal fixation with three parallel cannulated screws from January 2012 to 2019 in Huashan Hospital. Based on principles of "Gotfried reduction," all enrolled were divided into groups: anatomic intraoperatively or immediately...
Abstract Purpose The aim of this study is to investigate the prognostic value tibial component coverage (over-hang and under-hang) alignment total knee arthroplasty (TKA) components 1 week after surgery. We select patient-reported outcome measures (PROMS) (the Knee Society score (KSS score) Western Ontario McMaster Universities Osteoarthritis Index-pain (WOMAC pain score)) bone resorption (TBR) 2 years surgery as end points. Methods retrospectively analyzed 109 patients undergoing TKA...
Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation gene expression and contribute to growth, differentiation, apoptosis cancer cells. In this study, we firstly investigated biological function HDAC5 osteosarcoma We found that mRNA protein levels were upregulated tissues cell lines. Furthermore, overexpression could promote proliferation contrast, knockdown using small interfering RNA inhibited proliferation. At molecular level,...
Several methods are available for the treatment of early-stage osteonecrosis femoral head. Core decompression with implantation is a widely-used treatment. However, no single implant recognized as most effective way to prevent disease progression. Silk has high strength and resiliency. This study explored possibility strong resilient silk protein biomaterial new alternative implant.We investigated biomechanical properties material by regular compression, torsion, three-point bending tests....
The purpose of this study is to investigate the microbial patterns periprosthetic joint infection (PJI) and fracture-related (FRI), guide for formulation more accurate empirical antimicrobial regimens based on differences in pathogen distribution.A comparative analysis distribution was conducted between 153 patients (76 with PJI 77 FRI). Predicted analyses against isolated pathogens from two cohorts were evaluate best expected efficacy (imipenem + vancomycin, ciprofloxacin...
This study investigated the effect of knee position during wound closure on early function recovery after total arthroplasty (TKA).This included 80 primary arthroplasties due to osteoarthritis. The patients were randomized according type closure: extension group for full and flexion 90° flexion. incision articular capsule was marked precise alignment. In group, kept in high 1 2 min closure. two groups treated with same postoperative rehabilitation exercises. range motion (ROM), visual...
To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on recurrence pigmented villonodular synovitis (PVNS) knee joint treated by arthroscopic surgery combining local radiotherapy.Sixty pathological-proven PVNS cases in our department from April 2006 to March 2017 were included. All them are synovectomy combined with adjuvant radiotherapy. The pre-operative hematological indexes such as c-reactive protein (CRP), erythrocyte sedimentation rate (ESR),...
Abstract Background Postoperative delirium (PD), as an acute brain failure, is widely reported a very common postoperative complication, and it closely associated with increased morbidity mortality. Recently, malnutrition one of the risk factors for PD. The prognostic nutritional index (PNI) simple method evaluation. However, few studies have discussed effectiveness PNI assessment in predicting PD after primary total joint arthroplasty (TJA). aim this study to investigate potential including...
An increasing number of patients with hepatitis B virus (HBV) infection are undergoing total joint arthroplasty (TJA) surgery in China. Less attention is provided to the special populations and purpose this study assess effect HBV on prognosis TJAs.We retrospectively reviewed who underwent elective primary hip knee arthroplasties Shanghai Huashan Hospital from 2013 2016. Non-hepatitis cohort was built match case identify whether a risk factor associated postoperative complications. A 196...
Abstract Wide en bloc excision of proximal ulna sections is used to treat traumatic and pathological fractures the ulna, though poor standardization clinical treatment often results in long-term failure such reconstructed biomechanical structures. In order provide insight into effective ulnar reconstructive treatments, case an 80-year-old Chinese Han male presenting with fracture caused by a metastatic tumor concurrent renal cancer complicated occurrence brain lungs reported contrasted...
Apart from transepicondylar axis, the native femoral sulcus was also reported to be used as a guide for component position in total knee arthroplasty (TKA). However, it not shown patients with severe osteoarthritis. This study conducted compare of trochlear groove and without osteoarthritis, assess whether could TKA Total 50 osteoarthritis (Kellgren Lawrence grade 3 or 4) who underwent were included. Meanwhile, arthroscopic surgery included control. The distance midpoint virtual anterior...