A5079556116- Sarcoma Diagnosis and Treatment
- Beetle Biology and Toxicology Studies
- Livestock and Poultry Management
- Animal Genetics and Reproduction
- Immunotherapy and Immune Responses
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Spider Taxonomy and Behavior Studies
- Vascular Tumors and Angiosarcomas
- Electron and X-Ray Spectroscopy Techniques
- Uterine Myomas and Treatments
- Genetic diversity and population structure
- Urologic and reproductive health conditions
- melanin and skin pigmentation
- Livestock Farming and Management
- Lung Cancer Diagnosis and Treatment
- Nuts composition and effects
- Lymphoma Diagnosis and Treatment
- Plant Physiology and Cultivation Studies
- Genomics and Phylogenetic Studies
- Environmental DNA in Biodiversity Studies
- Cardiac tumors and thrombi
- Animal Nutrition and Physiology
- Molecular Biology Techniques and Applications
Inserm
2019-2025
Centre de Recherche en Cancérologie de Toulouse
2019-2025
Institut Claudius Regaud
2020-2023
Centre National de la Recherche Scientifique
2023
Université Toulouse III - Paul Sabatier
2023
Université de Toulouse
2019-2023
Génétique Physiologie et Systèmes d'Elevage
2017-2019
Institut National Polytechnique de Toulouse
2019
École Nationale Vétérinaire de Toulouse
2019
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2018
Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic disease remains resistant to immunotherapy by checkpoint blockade (ICB). Here, we show, CRC preclinical models, that orthotopically implanted primary colon tumors exert a colon-specific antimetastatic effect on distant hepatic lesions. Enterotropic α4β7 integrin–expressing neoantigen-specific CD8 T cells were key components effect. Accordingly, presence concomitant improved control liver lesions...
Abstract The helmeted guinea fowl Numida meleagris belongs to the order Galliformes. Its natural range includes a large part of sub‐Saharan Africa, from Senegal Eritrea and Chad South Africa. Archaeozoological artistic evidence suggest domestication this species may have occurred about 2,000 years BP in Mali Sudan primarily as food resource, although villagers also benefit its capacity give loud alarm calls case danger, ability consume parasites such ticks hunt snakes, thus suggesting...
Abstract Tumor-specific T cells play a central role in tumor control, yet the attainment of their full rejection potential is hindered by regulatory mechanisms, including expression inhibitory immune checkpoints. Although immunotherapy checkpoint blockade (ICB) has transformed cancer care, only proportion patients experience clinical benefit. Ancillary studies to trials evaluating ICB have revealed an association between high mutational burden (TMB) and treatment efficacy, suggesting that...
In quail, two feather colour phenotypes i.e. fawn-2/beige and yellow are associated with the ASIP locus. The aim of our study was to characterize structural modifications within this locus that explain mutation (large deletion) (assumed be caused by a different modification).For phenotype, we identified complex involves 141,162-bp long deletion. For 71-kb tandem duplication comprises one unchanged copy present in ITCH-ASIP fusion gene, which leads transcript coding for normal protein....
Uterine leiomyosarcoma, which accounts for 7% of all soft-tissue sarcomas and 1%-3% uterine malignancies, is an aggressive tumor responsible a significant proportion cancer-related deaths. While Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage the most important prognostic factor, metastatic relapse rates at I exceed 50% so it currently impossible to predict clinical outcome leiomyosarcomas. In 2010, our team published transcriptomic signature composed 67 genes...
Whole genome and transcriptome sequencing of a cohort 67 leiomyosarcomas has been revealed ATRX to be one the most frequently mutated genes in after TP53 RB1. While its function is well described alternative lengthening telomeres mechanism, we wondered whether alteration could have complementary effects on sarcoma oncogenesis. associated with down-expression linked differentiation leiomyosarcomas, immunity an additional 60 poorly differentiated pleomorphic sarcomas. In vitro vivo models...
In leiomyosarcoma (LMS), a very aggressive disease, relatively transcriptionally uniform subgroup of well-differentiated tumors has been described and is associated with poor survival. The question raised how differentiation tumor progression, two apparently antagonist processes, coexist allow malignancy. We first identified the most homogeneous LMS in three independent cohorts, which we named ‘hLMS’. integration multi-omics data functional analysis suggests that hLMS originate from vascular...
Whole-genome doubling is the second most frequent genomic event, after TP53 alterations, in advanced solid tumors and associated with poor prognosis. Tetraploidization step will lead to aneuploidy chromosomic rearrangements. The mechanism leading tetraploid cells important since endoreplication, abortive cytokinesis cell fusion could have distinct consequences. Unlike processes based on duplication, involves merging of two different genomes, epigenomes cellular states. Since it involved...
Background While much progress has been accomplished in the understanding of radiation-induced immune effects tumors, little is known regarding mechanisms involved at tumor draining lymph node (TDLN) level. The objective this retrospective study was to assess and biological changes arising non-involved TDLNs upon sparing concurrent chemoradiotherapy (CRT) non-small cell lung cancer (NSCLC) tumors. Methods Patients with proven localized (cN0M0) NSCLC, treated by radical surgery plus...
Abstract In leiomyosarcoma (LMS), a very aggressive disease, relatively transcriptionally uniform subgroup of well differentiated tumors has been described and is associated with poor survival. The question raised how differentiation tumor progression, two apparently antagonist processes, coexist allow malignancy. We first identified the most homogeneous LMS in three independent cohorts, which we named ‘hLMS’. integration multi-omics data functional analysis suggests that hLMS originate from...
Abstract Soft tissue sarcoma represents about 1% of all adult cancers. Occurrence multiple sarcomas in a same individual cannot be fortuitous. A 72-year-old patient had between 2007 and 2016 glomangiopericytal tumor the right forearm succession extremities: leiomyosarcoma left buttock, myxofibrosarcoma (MFS) forearm, MFS scapula, latero-thoracic two undifferentiated on forearm. Pathological examination six locations was not favor disease with local/distant recurrences but could confirm...
<p>Table. Clinico-morphologic and genomic data.</p>
<p>Table. Clinico-morphologic and genomic data.</p>
<div>AbstractPurpose:<p>Uterine leiomyosarcoma, which accounts for 7% of all soft-tissue sarcomas and 1%–3% uterine malignancies, is an aggressive tumor responsible a significant proportion cancer–related deaths. While Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage the most important prognostic factor, metastatic relapse rates at I exceed 50% so it currently impossible to predict clinical outcome leiomyosarcomas. In 2010, our team published...
<div>AbstractPurpose:<p>Uterine leiomyosarcoma, which accounts for 7% of all soft-tissue sarcomas and 1%–3% uterine malignancies, is an aggressive tumor responsible a significant proportion cancer–related deaths. While Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage the most important prognostic factor, metastatic relapse rates at I exceed 50% so it currently impossible to predict clinical outcome leiomyosarcomas. In 2010, our team published...
Abstract Whole genome and transcriptome sequencing of a cohort 67 leiomyosarcomas revealed ATRX to be one the most frequently mutated genes in after TP53 RB1 . While its function is well described alternative lengthening telomeres mechanism, we wondered whether alteration could have complementary effects on sarcoma oncogenesis. associated with down-expression linked differentiation leiomyosarcomas, immunity an additional 60 poorly differentiated sarcomas. In vitro vivo models showed that...