Purpose. To report the long-term follow-up results in patients with cataract and primary open-angle glaucoma (POAG) randomly assigned to surgery combined micro-bypass stent implantation or phacoemulsification alone. Methods. 36 subjects POAG were randomized a 1 : 2 ratio either iStent (combined group) alone (control group). 24 agreed be evaluated again 48 months after surgery. Patients returned one month later for unmedicated washout assessment. Results. At visit we reported mean IOP of 15,9...

To describe recurrence patterns and investigate candidate risk factors for recurrences of central serous chorioretinopathy.In 46 patients with acute chorioretinopathy follow-up >12 months after first episode resolution, parameters influencing were retrospectively evaluated using a frailty Cox proportional hazard survival model. Covariates included baseline systemic findings: age, gender, corticosteroid use, stress, shift work, sleep disorder, depression, allergy, cardiovascular risk; optical...

Purpose The aim of this study was to evaluate the effect anti-vascular endothelial growth factor (VEGF) therapy on choroidal neovascularisation (CNV) complicating central serous chorioretinopathy (CSC) using multimodal imaging, and identify possible predictive factors treatment response. Design Retrospective study. Methods Data 27 eyes with CNV CSC treated anti-VEGF (either ranibizumab or aflibercept) were reviewed. Response evaluated by change in visual acuity, intra/subretinal fluid...

To determine the evolution of fundus autofluorescence (FAF) patterns in chronic central serous chorioretinopathy (CSCR) over time.We retrospectively studied changes FAF time 157 eyes 112 patients with CSCR using Heidelberg Retina Angiography a 488-nm excitation light and 500-nm cutoff barrier filter.The mean duration follow-up was 37.2 months. The most common baseline pattern that granular hypoautofluorescence (51.0%). earliest change is diffuse hyperautofluorescence it occurs approximately...

To evaluate the long-term oral mineralocorticoid receptor antagonist (MRa) treatment in chronic central serous chorioretinopathy (CSC).Patients with non-resolving CSC (defined as foveal subretinal fluid (SRF) lasting >4 months retinal pigment epithelium (RPE) alterations) treated MRa only (eplerenone or spironolactone) for at least 6 were retrospectively included. Clinical and imaging characteristics recorded during visits baseline, 6, 12, 18 24 months.Sixteen eyes of 16 patients included...

Rhegmatogenous retinal detachment (RD) is a threatening visual condition and human disease model for degenerations. Despite successful reattachment surgery, vision does not fully recover, due to subretinal fluid accumulation subsequent photoreceptor cell death, through mechanisms that recapitulate those of degenerative diseases. Hydrophilic bile acids are neuroprotective in animal models, but whether they can be used orally diseases unknown. Ursodeoxycholic acid (UDCA) being approved...

Central serous chorioretinopathy (CSCR) belongs to the pachychoroid spectrum, a pathological phenotype of choroidal vasculature, in which blood flow is under nervous system (ChNS) regulation. The pathogenesis CSCR multifactorial, with most recognised risk factor being intake glucocorticoids, activate both gluco- and mineralocorticoid (MR) receptors. As MR over-activation pathogenic retina choroid, it could mediate effects glucocorticoids CSCR. But role signalling unknown whether affects ChNS...

Purpose: Indocyanine green (ICG) is an albumin and lipoprotein binding dye absorbing in the far red used angiography to visualize choroidal vessels (ICG [ICGA]). To guide interpretation, ICG transport choroid, RPE, retina of rats was studied. Methods: Two conditions were used: RPE/choroid organoculture, incubated for 45 minutes DMEM medium, 1% fetal bovine serum containing 0.25 mg/mL neural flat-mounts at 1 6 hours after intravenous injection. Early late sequences ICGA recorded until hours....

Central serous chorioretinopathy (CSCR), the fourth leading cause of retinal disease, tends to affect men and is favored by corticosteroids. Untargeted systemic metabolomics was analyzed in 60 with CSCR age-matched controls using UHPLC-MS. The analysis sera revealed a total 722 metabolites that differed significantly between control groups, 592 being downregulated 130 upregulated. metabolic profile exhibited incomplete breakdown products protein digestion or catabolism, fatty acid...

To investigate factors associated with macular atrophy (MA) incidence in neovascular age-related degeneration treated either ranibizumab or aflibercept an Observe-and-Plan variable dosing regimen.Information was obtained from two identical prospective treatment protocols using a regimen termed "Observe and Plan." Eyes without MA at baseline were included. New the final 2-year visit investigated univariate multivariate analysis to identify risk factors, focusing on factors.De novo developed...

Central serous chorioretinopathy (CSCR) is a retinal disease affecting the pigment epithelium (RPE) and choroid. This recognized side-effect of glucocorticoids (GCs), administered through nasal, articular, oral dermal routes. However, CSCR does not occur after intraocular GCs administration, suggesting that hypothalamic-pituitary-adrenal axis (HPA) brake could play role in mechanistic link between GS. The aim this study was to explore hypothesis. To induce HPA brake, Lewis rats received...

The exact link between systemic and ocular endogenous corticoids (steroidome) is unclear whether the steroidome altered in CSCR eyes unknown. aims of this study were to analyze human aqueous humor as a function age, sex time day, correlate long lasting complex inactive CSCR. Based on our results, we present two cases treated by combination oral mineralocorticoid antagonist glucocorticoids drops. In cross-sectional study, (AH) was collected 8am 6 pm from 50 unaffected individuals (25 men 25...

(1) Indocyanine green angiography (ICG-A) shows the presence of mid-phase hyperfluorescent area in central serous chorioretinopathy (CSCR). However, their exact meaning remains uncertain. (2) The clinical and multimodal imaging findings 100 patients (133 eyes) with CSCR, including enhanced-depth-imaging OCT (EDI-OCT), blue-light fundus autofluorescence (BAF), fluorescein indocyanine (FA ICG-A) were reviewed. Mid-phase plaques (MPHP) defined as fairly well circumscribed regions during...

No systemic biomarker of Central Serous Chorioretinopathy (CSCR) has been identified. Lipocalin 2 (LCN2 or NGAL), alone complexed with MMP-9 (NGAL/MMP-9), is increased in several retinal disorders. Serum levels LCN2 and NGAL/MMP-9 were measured CSCR patients (n = 147) chronic 76) acute/recurrent disease 71) age- sex-matched healthy controls 130). Samples CRP > 5 mg/L, creatinine 100 µmol/L, and/or urea 7.5 mmol/L excluded. was lower than (81.4 ± 48.7 vs 107.3 44.5 ng/ml, p < 0.0001), (p...

To investigate the association between 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.Cross-sectional multicenter study.Patients CSCR compared age- sex-matched healthy participants.Patients from centers in Europe were included study. The clinical form of was recorded. Blood samples patients participants sampled, high-sensitivity CRP levels measured serum.C-reactive serum level...

To assess the rate of late phase hyperfluorescent plaque (LPHP) in Type 1 macular neovascularization (MNV) central serous chorioretinopathy (CSCR) and age-related degeneration (AMD) to evaluate its prognostic value.Retrospective study including MNV AMD CSCR, from 2012 2020. Eyes with a indocyanine green angiography image (>20 minutes) clear visualization on optical coherence tomography (OCTA) were included. Quantitative qualitative parameters best-corrected visual acuity recorded at baseline...

Background/aims To investigate the factors associated with macular atrophy (MA) growth rates in neovascular age-related degeneration treated either ranibizumab or aflibercept. Methods We obtained data from two identical prospective studies using aflibercept under observe-and-plan variable dosing regimens. analysed eyes that presented MA within 2 years. After applying square root transformations to sizes, we calculated rate baseline year endpoint and used univariate multivariate analyses...

Purpose: To report the case of a small pigmented tumor in macular region investigated using optical coherence tomography angiography (OCT-A) context multimodal approach. Methods: Case Results: A 24-year-old man was referred for evaluation an asymptomatic unilateral round comma-shaped located his right eye. Spectral-domain OCT revealed irregular hyperreflective mass within retina, with thickened hyaloid membrane and abrupt margins, complete posterior shadowing effect. On fluorescein...

Some patients with neovascular age-related macular degeneration (nAMD) respond insufficiently to anti-VEGF treatment despite maximal monthly intravitreal injections. Their short-term response between injections was investigated for extent and visual prognosis.

Purpose: The purpose of this study was to report the functional and anatomical outcomes a prospective resulting from repeated dexamethasone intravitreal implants in patients with uveitic refractory macular edema. Methods: Twelve eyes 9 intermediate posterior noninfectious inflammatory uveitis complicated edema were regularly reviewed after implant. Patients examined at baseline, 30, 90, 135, 180 days best-corrected visual acuity (BCVA), complete slit-lamp examination, intraocular pressure...