A5100753436- Cytomegalovirus and herpesvirus research
- Ocular Oncology and Treatments
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Complementary and Alternative Medicine Studies
- Global Health and Surgery
- Poxvirus research and outbreaks
- Palliative Care and End-of-Life Issues
- Glaucoma and retinal disorders
- Viral-associated cancers and disorders
- Retinal and Optic Conditions
- Herpesvirus Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Oral microbiology and periodontitis research
- Global Maternal and Child Health
- Retinopathy of Prematurity Studies
- COVID-19 and healthcare impacts
- Dermatological and COVID-19 studies
- Cutaneous Melanoma Detection and Management
- Neurosurgical Procedures and Complications
- Child Abuse and Related Trauma
- Hepatitis C virus research
- Digital Mental Health Interventions
- Injury Epidemiology and Prevention
- Trauma and Emergency Care Studies
Oregon Health & Science University
2009-2025
Washington University in St. Louis
2021
Indiana University School of Medicine
2021
AMPATH
2021
Riley Hospital for Children
2021
Moi University
2021
Indiana University – Purdue University Indianapolis
2021
Methodist Hospital
2019
Methodist Hospital
2018
Midwest Eye Institute
2014
ABSTRACT Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola virus, the causative agent of smallpox. Human MPXV infection results in a disease that similar smallpox and can also be fatal. Two clades have been identified, with viruses central African clade displaying more pathogenic properties than those within west clade. The monkeypox inhibitor complement enzymes (MOPICE), which not expressed by clade, has hypothesized main virulence factor responsible for increased...
Liu H, Maida CA, Spolsky VW, Shen J, Li Zhou X, Marcus M. Calibration of self‐reported oral health to clinically determined standards. Community Dent Oral Epidemiol 2010; 38: 527–539. © 2010 John Wiley & Sons A/S Abstract – Objective: Self‐report is an inexpensive approach assessing individual’s status, but it heavily influenced by personal views and usually differs from that status. To assist researchers clinicians in estimating self‐report, we summarize measures can objectively measure...
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus associated with sarcoma and B cell malignancies. Like all herpesviruses, KSHV contains conserved envelope glycoproteins (gps) involved in virus binding, entry, assembly, release from infected cells, which are also targets of the immune response. Due to lack reproducible animal model infection, precise functions gps during infection vivo not completely known. Fortunately, nonhuman primate (NHP) disease has...
Abstract Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. Early detection offers best opportunity for effective treatment. Although CRC screening methods exist, there remains a need high performing blood test to both improve adherence and detect early stage disease. We have previously identified developed novel category cancer-associated, small orphan non-coding RNAs (oncRNAs), combined them with generative AI modeling develop liquid...
Understanding viral pathogenesis is challenging because of confounding factors, including nonabrasive access to infected tissues and high abundance inflammatory mediators that may mask mechanistic details. In diseases such as influenza smallpox where the primary cause mortality results from complications in lung, characterization lung fluid offers a unique opportunity study host-pathogen interactions with minimal effect on animals. This investigation characterizes global proteome response...
ABSTRACT Rhesus macaque rhadinovirus (RRV) is a gammaherpesvirus of rhesus (RM) monkeys that closely related to human herpesvirus 8 (HHV-8)/Kaposi's Sarcoma-associated (KSHV), and it capable inducing diseases in simian immunodeficiency virus (SIV)-infected RM are similar those seen humans coinfected with HIV HHV-8. Both HHV-8 RRV encode viral CD200 (vCD200) molecules homologues cellular CD200, membrane glycoprotein regulates immune responses helps maintain homeostasis via interactions the...
Retinal hemorrhages in healthy children with or without a history of associated trauma are strong indicator child abuse. This report describes six cases battered infants who presented white-centered retinal hemorrhages. We discuss potential mechanisms for the presence children.
Three HIV-seropositive subjects presented with diffuse inferior retinal hemorrhages. The first patient had an hemicentral vein occlusion subsequent development of cytomegalovirus retinitis. Two other patients 'hemorrhagic' retinitis mimicking a venous occlusion, the being subtle in 1 patient. We speculate that: (1) may predispose to infection retina by stasis and ischemic loss endothelium; (2) early large veins give picture hemorrhagic retinopathy subset differential diagnoses include:...
A healthy 12 month old infant without significant medical history presented with left eye redness for one week. Ophthalmic examination showed elevated intraocular pressure iris neovascularization in the affected increased optic nerve cupping. Scleral depression revealed a ciliary body mass supratemporal quadrant. large, non-pigmented, vascular was noted; biopsy results multilayered cords, tubules, and sheets resembling primitive medullary epithelium arising from body. The patient diagnosed...
Optic nerve sheath fenestration (ONSF) is a well-known, relatively safe, and effective surgical treatment for visual loss related to papilledema. Visual following ONSF uncommon but can occur from direct trauma, ischemic optic neuropathy, orbital or intrasheath hemorrhage, arterial occlusion. Transient severe (e.g., light perception (LP) no (NLP) loss) after has been reported. We describe case of LP vision uncomplicated with imaging demonstrating significant postoperative inflammation slow...
A 67-year-old woman presented with acute loss of vision to no light perception (NLP), a right afferent pupillary defect, and anisocoria nonreactive dilated pupil in the eye. Fundus examination showed pallid optic disc edema central retinal artery occlusion (CRAO) temporal biopsy giant cell arteritis (GCA). Orbital involvement GCA has been reported previously. However combination an efferent NLP vision, edema, CRAO elderly patient is likely unique clinical that should strongly suggest GCA....
Background: Addressing unmet palliative care needs in high-risk surgical patients low- and middle-income countries must include innovative approaches to limitations personnel culturally acceptable assessment modalities. Objectives: We assessed the utility of a novel seven-item "Step-1" trigger tool identifying who may benefit from care. Design: All adult (≥18 years) on general surgery, neurosurgery, orthopedic surgery wards were enrolled over four-month period. Setting/Subjects: This study...