A5001276145- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Refrigeration and Air Conditioning Technologies
- Bacillus and Francisella bacterial research
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- SARS-CoV-2 detection and testing
- Nitrogen and Sulfur Effects on Brassica
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Viral Infections and Vectors
- Linguistic Variation and Morphology
- Potato Plant Research
- Bartonella species infections research
- Essential Oils and Antimicrobial Activity
- Viral gastroenteritis research and epidemiology
- Phonetics and Phonology Research
- Phytochemistry and Biological Activities
- Rabies epidemiology and control
- Animal Disease Management and Epidemiology
- Food Supply Chain Traceability
- Mosquito-borne diseases and control
- Linguistics and Cultural Studies
- Ethnobotanical and Medicinal Plants Studies
University of Pittsburgh
2020-2025
Tulane University
2022-2023
University of Alabama in Huntsville
2018
University of Illinois Urbana-Champaign
1996
Goodwin College
1996
Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19) pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) model is a critical step process. Infection African green monkeys (AGM) with low passage human isolate SARS-CoV-2 by aerosol or mucosal exposure resulted mild clinical infection transient decrease lung tidal volume. Imaging clinical-grade 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) co-registered...
There is an urgent and unmet need for new antifungal therapies. Global fungal infection rates continue to rise infections pose increasing burdens on global healthcare systems. Exacerbating the situation, available therapeutic arsenal limited development of antifungals has been slow. Current are known unwanted side effects including nephrotoxicity hepatotoxicity. Thus, targets growing. A collection 60 commercially-available essential oils screened activity against Aspergillus niger, Candida...
Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasures. In this study, we show that pre-exposure prophylaxis broadly neutralizing antibody (bnAb) MEDI8852 is highly in protecting cynomolgus macaques from severe disease caused by aerosolized pathogenic avian H5N1 infection. Protection was dose–dependent yet independent Fc-mediated effector...
Abstract Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19) pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) model is a critical step process. Infection African green monkeys (AGM) with low passage human isolate SARS-CoV-2 by aerosol or mucosal exposure resulted mild clinical infection transient decrease lung tidal volume. Imaging clinical-grade 18 F-fluoro-2-deoxy-D-glucose positron emission tomography ( F-FDG PET)...
Highly pathogenic avian influenza A H5N1 viruses cause high mortality in humans and have pandemic potential. Effective vaccines treatments against this threat are urgently needed. Here, we refined our previously established model of lethal infection cynomolgus macaques. An inhaled aerosol virus dose 5.1 log
Since SARS-CoV-2 emerged in late 2019, it spread from China to the rest of world. An initial concern was potential for vaccine- or antibody-dependent enhancement (ADE) disease as had been reported with other coronaviruses. To evaluate this, we first developed a ferret model by exposing ferrets either mucosal inoculation (intranasal/oral/ocular) inhalation using small particle aerosol. Mucosal caused mild fever and weight loss that resolved quickly; via route resulted virus shedding detected...
Abstract Increases of soluble urokinase plasminogen activator receptor (suPAR) were measured in both urine and plasma a Chlorocebus aethiops (African green monkey; AGM) mucosal infected with SARS‐CoV‐2. The data indicate that elevated suPAR may be associated renal dysfunction pathology the context COVID‐19.
Highly pathogenic avian influenza A (HPAI) H5N1 viruses can cause high mortality in humans and have pandemic potential. Effective vaccines treatments against this threat are urgently needed. Here, we refined a previously established model of lethal infection cynomolgus macaques show that repeated vaccination adjuvanted commercial quadrivalent vaccine confers protection lethality using the model. We determined an inhaled aerosol virus dose 5.1 log10 pfu induced strong febrile response, acute...
ABSTRACT Since SARS-CoV-2 emerged in late 2019, it spread from China to the rest of world. An initial concern was potential for vaccine- or antibody-enhanced disease (AED) as had been reported with other coronaviruses. To evaluate this, we first developed a ferret model by exposing ferrets either mucosal inoculation (intranasal/oral) inhalation using small particle aerosol. Mucosal caused mild fever and weight loss that resolved quickly; via route resulted virus shedding detected nares,...
Abstract Francisella tularensis, a gram negative coccobacillus, is the causative agent of tularemia, severe zoonotic infection. When inhaled, as few 15 cfu sufficient to cause disease. There concern that tularemia could be used biological weapon so vaccines are urgently needed. We have previously shown New Zealand White (NZW) rabbit good model human disease; after exposure small particle aerosols containing virulent F. tularensis at doses low 66 cfu, naive NZW rabbits develop fever within 3...
Canola (Brassica napus L.) is one of the most important oilseed crops in world, with global production increasing almost 30% from 1980 to 1990. Because it produces oil that surprisingly low saturated fat, canola has become attractive today's health-oriented society. Although potential a major agronomic crop United States, relatively new Western cultures, facing problems environmental adaptation and social acceptance. With continued experimentation research, U.S. should continue increase.