A5031247498- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Global Maternal and Child Health
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Gestational Diabetes Research and Management
- Trauma and Emergency Care Studies
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- HIV/AIDS Research and Interventions
- Primary Care and Health Outcomes
- Infant Development and Preterm Care
- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- Reproductive Health and Contraception
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Child Nutrition and Water Access
- Healthcare Policy and Management
- Pregnancy-related medical research
- Renal function and acid-base balance
- Assisted Reproductive Technology and Twin Pregnancy
- Diabetes and associated disorders
Instituto de Efectividad Clínica y Sanitaria
2012-2021
Infant Foundation
2016-2020
Consejo Nacional de Investigaciones Científicas y Técnicas
2019
Western Cape Department of Health
2019
Hesco (United States)
2019
World Health Organization
1991-2017
Ghent University Hospital
2017
World Health Organization - Pakistan
2001-2010
Sunnybrook Health Science Centre
2009
Center for Medical Technology Policy
2009
Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered hospitalized patients has been unsuccessful, perhaps because antibodies should be earlier in course illness.We conducted a randomized, double-blind, placebo-controlled trial with high IgG titers against severe acute respiratory syndrome 2 (SARS-CoV-2) older adult within 72 hours after onset mild Covid-19 symptoms. The primary end point was disease,...
Randomized trials have traditionally been broadly categorized as either an effectiveness trial or efficacy trial, although we prefer the terms "pragmatic" and "explanatory." Schwartz Lellouch described these 2 approaches toward clinical in 1967. [1][1] These authors coined
Cesarean section rates show a wide variation among countries in the world, ranging from 0.4 to 40 percent, and continuous rise trend has been observed past 30 years. Our aim was explore association of cesarean different with their maternal neonatal mortality test hypothesis that low-income countries, increasing were associated reductions both outcomes, whereas high-income such did not exist.We performed cross-sectional multigroup ecological study using data 119 1991 2003. These classified...
Implementation of evidence-based obstetrical practices remains a significant challenge. Effective strategies to disseminate and implement such are needed.We randomly assigned 19 hospitals in Argentina Uruguay receive multifaceted behavioral intervention (including selection opinion leaders, interactive workshops, training manual skills, one-on-one academic detailing visits with hospital birth attendants, reminders, feedback) develop guidelines for the use episiotomy management third stage...
There are many systematic reviews of continuing education programmes and educational strategies for quality improvement in health care. Most the reviewed studies one-off evaluations rather than impact with long-term follow-up. few organisational, financial regulatory interventions, high-quality studies. These interventions probably as or more important strategies, although they less well evaluated. Few have been undertaken low- middle-income countries (LMIC) that address maternal child...
Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important death in infants developing world. The relative contribution social, biologic, clinical risk factors to RSV mortality low-income regions unclear.To determine burden for due a population 84,840 infants.This was prospective, population-based, cross-sectional, multicenter study conducted between 2011 2013. Hospitalizations deaths severe lower respiratory tract illness (LRTI) were recorded during...
BackgroundReducing deaths from hypertensive disorders of pregnancy is a global priority. Low dietary calcium might account for the high prevalence pre-eclampsia and eclampsia in low-income countries. Calcium supplementation second half known to reduce serious consequences pre-eclampsia; however, effect during placentation not known. We aimed test hypothesis that before early (up 20 weeks' gestation) prevents development pre-eclampsiaMethodsWe did multicountry, parallel arm, double-blind,...
While 30%–70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. TLR4 associated with these phenotypes, the role this receptor in respiratory syncytial (RSV) pathogenesis controversial. Here, we evaluated interaction between environmental factors RSV defined immune mediators severe illness. Two independent...
<h3>Abstract</h3> <b>Objective:</b> To explore the long term effect of calcium supplementation during pregnancy on offspring9s blood pressure childhood. <b>Design:</b> Follow up a population enrolled in double blind, randomised, placebo controlled trial. <b>Setting:</b> Perinatal research unit, World Health Organisation9s collaborative centre. <b>Subjects:</b> 591 children at mean age 7 years whose mothers were randomly assigned to receive 2 g/day elemental (n=298) or (n=293). <b>Main...
Maternal mortality remains a daunting problem in Mozambique and many other low-resource countries. High quality antenatal care (ANC) services can improve maternal newborn health outcomes increase the likelihood that women will seek skilled delivery care. This study explores factors influencing provider uptake of recommended package ANC interventions Mozambique. used qualitative research methods including key informant interviews with stakeholders from sector total five focus group...
Numerous deaths in children aged <5 years the developing world occur at home. Acute respiratory infections (ARIs) are thought to play an important role these deaths. Risk factors and pathogens linked fatal episodes remain unclear. A case-control study among low-income was performed Buenos Aires, Argentina, define risk viral those who died of ARI total 278 families (of whom 104 174 were healthy controls) participated study. 87.5% ARI-associated occurred infants <12 months. The estimated...
Background Obstetric hemorrhage is the leading cause of maternal mortality. Using a cluster randomized design, we investigated whether application Non-pneumatic Anti-Shock Garment (NASG) before transport to referral hospitals (RHs) from primary health care centers (PHCs) decreased adverse outcomes among women with hypovolemic shock. We hypothesized NASG group would have 50% reduction in outcomes. Methods and Findings randomly assigned 38 PHCs Zambia Zimbabwe standard obstetric...
Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, also blood pressure (BP).This exploratory sub-study of WHO Pre-eclampsia (CAP) trial aims to determine effect 500mg/day elemental on non-pregnant women previous pre-eclampsia. Non-pregnant at least one subsequent follow-up visit approximately 12 or 24weeks after randomization were...