A5034942075- Porphyrin and Phthalocyanine Chemistry
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Photosynthetic Processes and Mechanisms
- Metal-Catalyzed Oxygenation Mechanisms
- Supramolecular Self-Assembly in Materials
- Hippo pathway signaling and YAP/TAZ
- Magnetism in coordination complexes
- Protein Tyrosine Phosphatases
- Pancreatic function and diabetes
- ATP Synthase and ATPases Research
- Angiogenesis and VEGF in Cancer
- Photochemistry and Electron Transfer Studies
- Apelin-related biomedical research
- Photodynamic Therapy Research Studies
- Genetics and Neurodevelopmental Disorders
- Polydiacetylene-based materials and applications
- Supramolecular Chemistry and Complexes
- Genomics and Rare Diseases
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Childhood Cancer Survivors' Quality of Life
- Porphyrin Metabolism and Disorders
University of Toledo
2012-2025
Ministry of Natural Resources
2022
First Institute of Oceanography
2022
Software (Spain)
2019
Sinopec (China)
2013
China Institute of Atomic Energy
2011
Jilin University
1997-2009
Northwestern University
2007-2009
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2009
National Natural Science Foundation of China
2005
Down syndrome cell adhesion molecule (DSCAM) is required for axon guidance and dendrite arborization. How DSCAM functions in vertebrates not well understood. Here we show that expressed on commissural axons interacts with Netrin-1, a prototypical cue axons. The knockdown of by specific siRNA or blockage signaling overexpression mutant lacking its intracellular domain inhibits netrin-induced outgrowth turning vitro. SiRNA-mediated ovo causes defects projection pathfinding. In transfected...
Abstract We report on the synthesis and self‐assembly of a new series discotic molecules containing triphenylbenzene as core alkoxy side chain with varying length. It was found that compounds 3 – c , 4 b 5 could form stable gels in several apolar solvents. Transmission electron microscopy (TEM) images revealed their morphologies were very different for alkoxy‐substituted organogels. In toluene or hexane, resulted both left‐ right‐handed helical fibers, whereas straight rigid fibers; most...
In the developing nervous system, neuronal growth cones explore extracellular environment for guidance cues, which can guide them along specific trajectories toward their targets. Netrin-1, a bifunctional cue, binds to deleted in colorectal cancer (DCC) and DSCAM mediating axon attraction, UNC5 repulsion. Here, we show that interacts with UNC5C this interaction is stimulated by netrin-1 primary cortical neurons postnatal cerebellar granule cells. partially co-localized brain tissues....
The coupling of axon guidance cues, such as netrin-1, to microtubule (MT) dynamics is essential for growth cone navigation in the developing nervous system. However, whether signaling regulates MT directly or indirectly unclear. Here, we report that TUBB3, most dynamic β–tubulin isoform neurons, interacts with netrin receptor DCC, and netrin-1 induces this interaction primary neurons. TUBB3 colocalizes DCC cones neurons required netrin-1-promoted association DCC. Netrin-1 not only increases...
Modulation of microtubule (MT) dynamics is a key event cytoskeleton remodeling in the growth cone (GC) during axon outgrowth and pathfinding. Our previous studies have shown that direct interaction netrin receptor DCC DSCAM with polymerized TUBB3, neuron-specific MT subunit brain, required for netrin-1-mediated outgrowth, branching, attraction. Here, we show uncoupling TUBB3 netrin-1-repulsive UNC5C involved axonal repulsion. directly interacted partially colocalized peripheral area GC...
A new series of binary organogels, which showed good gelated capability and strongly enhanced fluorescence emission, were designed prepared by simply mixing two components L-tartaric acid alkoxyl substituted stilbazoles. It was found that could not only introduce stilbazole with fluorescent property into the gel system, but also provided a main motif for formation gel-phase via multiple hydrogen bonds. Meanwhile, π–π interactions between complexes played key role in formation. The decreased...
Netrins are an important family of axon guidance cues. Here, we report that netrin-1 induces tyrosine phosphorylation p130 CAS (Crk-associated substrate). Our biochemical studies indicate is downstream the Src kinases and upstream small GTPase Rac1 Cdc42. Inhibition signaling blocks both neurite outgrowth-promoting activity attraction netrin-1. RNA interference inhibits commissural axons in spinal cord by causes defects projection embryo. These results demonstrate a key component netrin...
Interneurons in the olfactory bulb (OB) are generated not only developing embryo but also throughout postnatal life of mammals from neuronal precursor cells migrating anterior subventricular zone (SVZa) mammalian forebrain. We discovered that OB secretes a diffusible activity attracts these cells. The attractive is present specific layers OB, including glomerular layer granule cell layer. and responsiveness persist embryonic through neonatal to adult stages. Removal rostral significantly...
Temporospatial regulation of guidance signaling is essential for axon outgrowth and pathfinding in the developing nervous system. Regulation Robo1 levels commissural neurons modulates Slit sensitivity facilitating proper guidance. The mechanisms underlying this vertebrate system are not well understood. Here, we report that miR-92, a highly conserved microRNA (miRNA), regulates chicken expression by binding to 3' untranslated region (3' UTR) mRNA. miR-92 differentially expressed spinal cord....
In the developing spinal cord, translational repression of Robo1 expression by microRNA-92 (miR-92) in precrossing commissural axons (CAs) inhibits Slit/Robo1-mediated repulsion facilitating axon projection and midline crossing; however, regulatory mechanisms governing miR-92 neurons (CNs) are currently lacking. Here, we propose that transcription factor MYC regulates cord (of either sex) to control levels CAs, modulating crossing. MYC, miR-92, differentially expressed chicken cord. binds...
The first series of lanthanide(III) monobenzoporphyrin liquid crystalline compounds, meso-tetraalkyltetrabenzoporphyrin (TATBP) ytterbium hydroxy, and relative transition metal benzoporphyrin compounds (4 series, 24 kinds) are reported that display a hexagonal columnar discotic (Colh, previously designated Dh) phase. These have been studied by cyclic voltammetry, luminescence, surface photovoltage spectroscopies. In dimethylformamide (DMF) solution 0.1 M tetrabutylammonium perchlorate...
Abstract Background Cage-rearing in laying ducks, as a novel rearing system, not only fundamentally solves the pollution problem of duck industry and improve bio-safety product quality but also exhibits more benefits by implementing standardized production compared with floor-rearing. Of course, this system brings some welfare problems stress injuries to layers due lack water environment limited activities cages. However, effects on factors antioxidant defense inflammatory injury early cage...
meso-Tetraalkyltetrabenzoporphyrin (TATBP) and related transition metal benzoporphyrin liquid crystalline compounds, TATBPMnCl, TATBPNi, TATBPCu (4 series, 28 kinds) are reported that display a hexagonal columnar discotic (Colh) phase. These compounds have been studied by cyclic voltammetry, surface photovoltage spectroscopy (SPS), luminescence spectroscopy. In dimethylformamide (DMF), 0.1 M tetrabutylammonium perchlorate (TBAP), these synthesized exhibit two one-electron reversible redox...