A5043268641- Catalytic C–H Functionalization Methods
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis of Indole Derivatives
- Plant and fungal interactions
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Radical Photochemical Reactions
- Crystallization and Solubility Studies
- Advanced Synthetic Organic Chemistry
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Chemical Synthesis and Reactions
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
Qingdao Agricultural University
2023-2025
Ocean University of China
2022-2023
Laoshan Laboratory
2023
Qingdao National Laboratory for Marine Science and Technology
2022
The hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed with employment different Lewis acids.
The Brønsted acid-controlled switchable synthesis of indoline-fused tetrahydroquinolines and indole-fused benzazepines was developed through hydride transfer-enabled formal [5 + 1] 2] cyclization reactions from indoles N-alkyl o-aminobenzoketones. Indoline, furanone, tetrahydroquinoline hybridized pentacyclic products were unprecedentedly accessed via a cascade condensation/hydride transfer/dearomatization-cyclization/deethylation/nucleophilic addition process. In addition, the undeveloped...
Abstract Natural products are well established as an important resource and play role in drug discovery. Here, two pyrrolinone-fused benzoazepine alkaloids, (+)-asperazepanones A ( 1 ) B 2 with a 6/7/5 ring system, together the artifact (−)-asperazepanone ), were isolated from coral-derived Aspergillus candidus fungus. Their structures including absolute configurations elucidated by extensive spectroscopic methods, single crystal X-ray diffraction, ECD calculations. Furthermore, total...
The strong antibacterial, antiviral and anticancer activities demonstrated by quinolones make them promising lead structures important synthetic targets for drug discovery. Here, we report, to the best of our knowledge, first scalable total synthesis (+)-aniduquinolone A, possessing a 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one skeleton. This strategy explores E-stereoselective Horner-Wadsworth-Emmons (HWE) olefination as key step assemble isopropenyl substituted tetrahydrofuran...
The controllable synthesis of spirooxindole–dihydrofurans and spirooxindole–benzazepines was developed through formal [3 + 2] [5 cyclization reactions from 2-(2-oxoindolin-3-yl)malononitriles ortho-aminobenzaldehydes, respectively. A variety spirooxindole-benzazepines were facilely constructed via a furan ring-open-involved hydride transfer/cyclization process. It is noteworthy that the application hydride-transfer-involved strategy for construction spirobenzazepines unprecedented. In...
The Sc(OTf)3-catalyzed dearomative [5+1] annulations between readily available 3-aminophenols and O-alkyl ortho-oxybenzaldehydes were developed for synthesis of spiro[chromane-3,1′-cyclohexane]-2′,4′-dien-6′-ones. “two-birds-with-one-stone” strategy was disclosed by the dearomatization phenols direct α-C(sp3)–H bond functionalization oxygen through cascade condensation/[1,5]-hydride transfer/dearomative-cyclization process. In addition, antifungal activity assay derivatizations products...
Diversity-oriented synthesis of indole-1,2-fused 1,4-benzodiazepines, tetrahydro-β-carbolines, and 2,2′-bis(indolyl)methanes is presented by control reaction sites.
A highly efficient and scalable total synthesis of pesimquinolone I (1) was accomplished in 5 steps with 3 chromatographic purifications.
The first total synthesis of aflaquinolone I (1), which represents the example natural occurring 3,4-dioxygenated 4-aryl-quinolin-2(1H)-one alkaloid with 3R, 4R configurations, was achieved in 9 linear steps 30% overall yield from commercially available anthranilic acid. key included a base-catalyzed coupling reaction to forge α-hydroxyanilide and diastereoselective aldol cyclization construct 3,4-dioxygenated-4-aryl-quinolin-2(1H)-one core. In addition, dehydrated product I, viridicatol...
Inflammation is connected with a variety of diseases and there still need to develop more effective safer anti-inflammatory drugs. Herein, we synthesized, resolved, characterized eight enantiopure isomers yaequinolone J1(1), J2 (2), 4'-demethoxyyaequinolone J1 (3), (4). The key steps were extended other 34 racemic analogues modified at 4-aryl, N-position, pyran ring designed synthesized. All the synthesized compounds evaluated for their activities in RAW 264.7 cells 13 showed significant...