A5031845147- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Traditional Chinese Medicine Analysis
- Inflammatory mediators and NSAID effects
- Adipose Tissue and Metabolism
- Analytical Methods in Pharmaceuticals
- Natural product bioactivities and synthesis
- Fungal Plant Pathogen Control
- Geographic Information Systems Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Data Management and Algorithms
- Phytochemistry and Biological Activities
- Sirtuins and Resveratrol in Medicine
- Web Data Mining and Analysis
- Antioxidants, Aging, Portulaca oleracea
- Chemical Synthesis and Analysis
- Diet, Metabolism, and Disease
- Colorectal Cancer Treatments and Studies
- Garlic and Onion Studies
- Plant-based Medicinal Research
Yantai University
2024-2025
Wenzhou Medical University
2021-2025
Wenzhou City People's Hospital
2021
Age-related decline in nicotinamide adenine dinucleotide (NAD+)-a central regulator of cellular metabolism, DNA repair, and immune homeostasis-is strongly associated with physiological dysfunction. Nicotinamide mononucleotide (NMN), a potent NAD+ precursor, shows promise counteracting aging-related pathologies, particularly neurodegenerative decline. An aging model was established mice through 8-week D-galactose (D-gal) exposure, followed by NMN oral supplementation. Behavioral outcomes...
Introduction: A rapid and sensitive ultra high performance liquid chromatography (UPLC) method was developed validated for the determination of doxofylline its metabolite theophylline in rat plasma using caffeine as an internal standard. Methods: The analysis performed on a Waters Acquity C18 column (2.1 mm*50 mm, 1.7 µm) with detection wavelength setting at 273 nm. mobile phase acetonitrile water gradient elution flow-rate 0.2 ml/min. Results: calibration curves were linear range 0.3~500...
Abstract Objectives To unveil the mechanism of Bufei Huoxue formula (BHF) for chronic obstructive pulmonary disease (COPD) through integrated network pharmacology (NP) and experimental verification. Methods LC-MS was first applied to analysis both in vitro vivo samples from BHF chemical profiling. Then a ligand library prepared NP reveal against COPD. Finally, verification performed using an animal model related results NP. Key findings A containing 170 compounds obtained, while 357 targets...
Background: Aging is usually accompanied by a significant decline in nicotinamide adenine dinucleotide (NAD + ) level. Nicotinamide mononucleotide (NMN) crucial precursor molecule of NAD with variety bioactivities beneficial to health, and the present study just aimed explore antiaging effects NMN mechanism action using nontargeted metabolomic strategy. Methods: An aging mouse model induced D‐galactosamine (D‐gal) was established, which followed treatment (at doses 100 500 mg/kg per day) via...
With the immense scale and wide spread of social media, it gradually becomes an ultimate information repository. Much this now contains some form geographical content because proliferation location-aware devices, thus fostering emergence geo-social media. However, media retrial is a big challenge, as often generated continuously at ever faster rate by massive number users. So in order to address we propose Subject-oriented Geo-social Media Information Search Engine that can crawl save...
Background: To mitigate diabetes and its complications in cardiovascular diseases, the antidiabetic agent Glimepiride (GLM) is usually administered with Ferulic Acid (FA) concomitantly clinical settings. However, both drugs are prone to be metabolized partly by CYP2C9; thus, they have potential drug-drug interaction affecting safety efficacy. Objective: This study aimed evaluate Pharmacokinetic (PK) effects of ferulic acid on glimepiride metabolite hydroxy (OH-GLM) plasma using HPLCMS/ MS...
The aim of our study was to investigate the effects single-dose Ougan (Citrus reticulata cv. Suavissima) juice application on pharmacokinetics erlotinib in vivo. Twelve Sprague-Dawley rats were randomly divided into and control groups (n = 6 each). given a single dose 1 mL/100 g or normal saline (NS) by intragastric administration, followed oral administration 20 mg/kg erlotinib. plasma concentration determined using ultra performance liquid chromatography-tandem mass spectrometry...