Flavonoids have been reported to play an essential role in modulating processes of cellular redox homeostasis such as scavenging ROS. Meanwhile, they also induce oxidative stress that exerts potent antitumor bioactivity. However, the contradiction between these two aspects still remains unclear. In this study, four typical flavonoids were selected and studied. The results showed low-dose slightly promoted proliferation breast cancer cells under normal growth via gradually reducing...

Breast cancer, the most common cancer in women, usually exhibits intrinsic insensitivity to drugs, even without drug resistance. MUC1 is a highly glycosylated transmembrane protein, overexpressed breast contributing tumorigenesis and worse prognosis. However, molecular mechanism between sensitivity still remains unclear. Here, natural flavonoid apigenin was used as objective due antitumor activity wide availability. knockout (KO) markedly sensitized cells cytotoxicity vitro vivo. Both...

The accumulation of antibiotics in the aquatic environment is increasingly becoming a risk to health animal. purpose this study was investigate acute and chronic toxicity florfenicol (FF) zebrafish. A 56-day test followed 96-h test. divided into five FF concentration groups: 0 mg/L (C), 5 (T5), 10 (T10), 20 (T20) 40 (T40). Each group had replicates, with Zebrafish per replicate. results showed that 96 h-LC50 greater than 2000 mg/L, indicating low toxicity. exposure concentrations exceeding...

Abstract This study evaluated the impacts of sulfamethoxazole (SMX) on antioxidant, immune, histopathological dynamic changes, and gut microbiota zebrafish. SMX was carried out five groups: 0 (C), 3 mg/L (T3), 6 (T6), 12 (T12), 24 (T24), with 5 replicates per group for an 8-weeks chronic toxicity test. It found that is considered to have low adult concentration not higher than has no obvious inhibitory effect growth fish. Under different concentrations stress, oxidative damage immune system...

Abstract This study was conducted to investigate the relationship between different cornstarch levels in tilapia diet and immune function. All test fish were fed with three levels: low-cornstarch (0, LS), medium-cornstarch (18%, MS) high-cornstarch (36%, HS) diets. Three hundred sixty (initial mean body weight 31.73 ± 1.36 g) randomly allocated into twelve water-circulated tanks, thirty per tank. Compared low medium diets, results of growth showed that high significantly decreased FBW, WGR,...

Phenolic acids (PAs), a class of small bioactive molecules widely distributed in food and mainly found as secondary plant metabolites, present significant advantages such antioxidant activity other health benefits. The global epidemic nonalcoholic fatty liver disease (NAFLD) is becoming serious public problem. Existing studies showed that gut microbiota (GM) dysbiosis highly associated with the occurrence development NAFLD. In recent years, progress has been made study relationship among PA...

A feeding trial was conducted to evaluate the results of replacing soybean meal (SBM) with other blend plant protein (BP) (rapeseed meal, cottonseed and peanut meal) sources on growth, fish body composition, biochemical parameters, non-specific immune index gene expression growth hormone/insulin-like factor-1 in Yellow River carp Cyprinus carpio. The showed that 600 g/kg replacement BP diet did not affect performance carp, but 800 SBM could depress (p < .05). significantly impacted...

Some people with upper body motor impairments but sound lower limbs usually use feet to interact smartphones. However, touching the touchscreen big toes is tiring, inefficient and easy mistouch. In this paper, we propose FootUI, which leverages phone camera track users' translates foot gestures smartphone operations. This technique enables users smartphones while reclining on bed improves comfort of users. We explore usage scenario gestures, define mapping from operations develop prototype...

Five treatment groups were set up in the feeding experiment: fishmeal diet (positive control, PC), fishmeal-free (negative NC), complex amino acid 1 (0.4% alanine, 0.5% arginine and 0.7% glycine, AA1), AA2 glycine 0.2% histidine), AA3 (0.5% arginine, histidine). Each had 4 replicates with 40 fish (initial weight 12.81 ± 0.17 g). The results showed that compared NC group, AA1 attractants significantly increased final body weight, gain rate, specific growth rate decreased viscera index...

Administering ferulic acid and protocatechuic acid, which can activate brown fat thermogenesis, to ApoE −/− mice alleviate atherosclerosis.

The study aimed to explore the effects of rosiglitazone on glucose metabolism GIFT tilapia based PI3K/Akt signaling pathway. experiment was divided into five groups: normal starch group (32%, LC), high (53%, HC), +rosiglitazone 1 (10 mg/kg, R1), + 2 (20 R2), and 3 (30 R3). results showed that a diet supplemented with 10–20 mg/kg had better specific growth rate protein efficiency beneficial for tilapia. Rosiglitazone no significant effect contents crude lipid, protein, ash, moisture whole...

Chemoresistance is a major obstacle to hepatocellular carcinoma (HCC) chemotherapy. Our previous study found that long noncoding RNA lncARSR (lncRNA Activated in RCC with Sunitinib Resistance) activated Akt signaling via repressing phosphatase and tensin homolog (PTEN) during doxorubicin resistance HCC. The purpose of this further explore lncARSR-mediated mechanisms roles expression was detected by real-time quantitative polymerase chain reaction (qPCR). Nuclear factor-kappa B (NF-κB)...

Abstract The purpose of this study was to evaluate the effects nonstarch polysaccharide (NSP) hydrolase (primarily xylanase and β‐glucanase), present in plant protein‐based diets, on growth, nutrient digestibility, protease/amylase activity Yellow River carp, Cyprinus carpio var.. Six hundred fish were randomly allocated four groups five replicates fed diets with different NSP enzyme levels (0, 0.025, 0.05, 0.1%) for 56 days. addition 0.05 0.1% enzymes significantly improved specific growth...

Abstract Poly(vinyl alcohol) (PVA)‐based hybrids have demonstrated broad liquid separation applications but performances are constrained by the compatibility between fillers and polymer, thus it is essential to study interfacial properties of these hybrids. In this work, PVA with four different porous been fabricated characterized Fourier transform infrared, X‐ray diffraction, Scanning electron microscope, swelling contact angle tests. Swelling results show that has a degree (DS) 79% in...