A5101884101- Prion Diseases and Protein Misfolding
- Pharmacological Effects of Natural Compounds
- Trace Elements in Health
- Muscle metabolism and nutrition
- Neurological diseases and metabolism
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Muscle Physiology and Disorders
- Circular RNAs in diseases
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Macrophage Migration Inhibitory Factor
- Biochemical Acid Research Studies
- Pain Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Retinal Development and Disorders
- Enzyme Structure and Function
- Photoreceptor and optogenetics research
- Plant-based Medicinal Research
- Endoplasmic Reticulum Stress and Disease
- S100 Proteins and Annexins
- Hematopoietic Stem Cell Transplantation
- Lipid metabolism and biosynthesis
- Coenzyme Q10 studies and effects
- Adipose Tissue and Metabolism
Huazhong Agricultural University
2024-2025
North Sichuan Medical University
2019-2024
South China Agricultural University
2016-2020
Beijing Red Cross Blood Center
2018
Jilin Agricultural University
2012
National Institute for Viral Disease Control and Prevention
2011
Center for Disease Control
2010
Chinese Center For Disease Control and Prevention
2010
Abstract Skeletal muscle weight loss is accompanied by small fiber size and low protein content. Alpha-ketoglutarate (AKG) participates in nitrogen metabolism. The effect of AKG on skeletal hypertrophy has not yet been tested, its underlying mechanism to be determined. In this study, we demonstrated that (2%) increased the gastrocnemius diameter mice. Our vitro study also confirmed dose synthesis C2C12 myotubes, which could effectively blocked antagonists Akt mTOR. effects were independent...
Soybean (Glycine max L.) is one of the most important oil crops in world. It desirable to increase yields from soybean, and so this has been a major goal oilseed engineering. However, it still uncertain how many genes which are involved lipid biosynthesis.Here, we evaluated changes gene expression over course seed development using Illumina (formerly Solexa) RNA-sequencing. Tissues at 15 days after flowering (DAF) served as control, total 11592, 16594, 16255 differentially expressed unigenes...
ABSTRACT Neutrophils and macrophages are indispensable phagocytic immune cells, critically responsible for fish's ability to combat pathogens. Studies unveil that ATP7A is essential copper trafficking the lysosome in a process fundamental their antibacterial functions vitro. However, its role vivo underlying mechanisms have been insufficiently explored. In this study, we demonstrated atp7a −/− mutant larvae significantly more susceptible Aeromonas hydrophila (AH) infection possess fewer...
Background Tubulin polymerization promoting protein/p25 (TPPP/p25), known as a microtubule-associated protein (MAP), is brain-specific unstructured with physiological function of stabilizing cellular microtubular ultrastructures. Whether TPPP involves in the normal functions PrP or pathogenesis prion disease remains unknown. Here, we proposed data that formed molecular complex PrP. We also investigated its influence on aggregation and fibrillization PrP106–126 vitro, antagonization against...
Skeletal muscle protein turnover is regulated by endocrine hormones, nutrients, and inflammation. α-Lipoic acid (ALA) plays an important role in energy homeostasis. Therefore, the aim of this study was to investigate effects ALA on synthesis skeletal muscles reveal underlying mechanism. (25 μM) significantly increased phosphorylation Akt, mTOR, S6 C2C12 myotubes with attenuated AMPK, Ikkα/β, eIF2α. Intraperitoneal injection 50 mg/kg also produced same results mouse gastrocnemius. Both PI3K...
Abstract As part of the central nervous system (CNS), retina senses light and also conducts processes visual impulses. The damaged development not only causes damage, but leads to epilepsy, dementia other brain diseases. Recently, we have reported that copper (Cu) overload induces retinal developmental defects down-regulates microtubule (MT) genes during zebrafish embryogenesis, whether down-regulation mediates Cu stress induced is still unknown. In this study, found gene stmn4 exhibited...
Development of the pathogenesis transmissible spongiform encephalopathies (TSEs) requires presence both normal host prion protein (PrPC) and abnormal pathological proteinase-K resistant isoform (PrPSc). Reduction PrPC levels has been shown to extend survival time after infection. In this report, based on analysis known sequences human PrP, we constructed two small interfering RNA (siRNA) duplexes targeting segments amino acids (aa) 108-114 (Ri2) aa 171-177 (Ri3). Western blot results...
The human leukocyte antigen (HLA) system plays a central role in the immune response to pathogens, as well organ and allogenic hematopoietic stem cell transplantation (HSCT). Finding five-locus (i.e., HLA-A, -B, -C, -DRB1, -DQB1) matched unrelated donor for patient awaiting HSCT is major clinical challenge, due lack of HLA-identical sibling donors high polymorphism HLA. To date, most studies providing HLA allele frequencies (AF) haplotype (HF) Chinese populations have focused on instead...