A5085917811- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heat shock proteins research
- Inhalation and Respiratory Drug Delivery
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pregnancy and preeclampsia studies
- Systemic Sclerosis and Related Diseases
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Inflammatory Myopathies and Dermatomyositis
- Atomic and Subatomic Physics Research
- Eosinophilic Disorders and Syndromes
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Birth, Development, and Health
Inserm
1999-2025
La Ligue Contre le Cancer
2025
Université de Bourgogne
2023-2025
Centre de recherche Translationnelle en Médecine moléculaire
2024
CHU Dijon Bourgogne
2022
Université Paris Cité
1999
Background Interstitial lung diseases (ILDs) include a large number of associated with progressive pulmonary fibrosis (PPF), including idiopathic (IPF). Despite the rarity each fibrotic ILDs individually, they cumulatively affect considerable patients. PPF is characterised by an excessive collagen deposition leading to functional decline. Objectives Therapeutic options are limited nintedanib and pirfenidone which only able reduce progression. CD206-expressing M2 macrophages involved in...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor outcome and limited therapeutic options. Imaging of IPF to high-resolution computed tomography (HRCT) which often not sufficient for definite diagnosis has impact on decision patient management. Hypoxia the lung significant feature but its role progression remains elusive. Thus, aim our study was evaluate hypoxia imaging [18F]FMISO as predictive biomarker therapy efficacy in preclinical models comparison...
Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by fibroblast activation abnormal accumulation of extracellular matrix in the lungs. We previously demonstrated importance heat shock protein α B‐crystallin (HSPB5) TGF‐ β 1 profibrotic signalling, which suggests that HSPB5 could be new therapeutic target for treatment IPF. The purpose this study was thus to develop antisense oligonucleotides targeting their effects on development experimental...
Idiopathic pulmonary fibrosis is a chronic, progressive and lethal disease of unknown etiology that ranks among the most frequent interstitial lung diseases. characterized by dysregulated healing mechanisms lead to accumulation large amounts collagen in tissue disrupts alveolar architecture. The two currently available treatments, nintedanib pirfenidone, are only able slow down without being curative. We demonstrated past HSPB5, low molecular weight heat shock protein, was involved...
<b>Introduction:</b> Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal form of interstitial lung disease, unknown aetiology. We have shown that the small heat shock protein 27 (HSP27) overexpressed in IPF patient lungs promotes fibrogenesis. In cancer, HSP27 can also be secreted, notably within extracellular vesicles (EVs). During IPF, EVs accumulate BAL. Our aim to characterize role during fibrosis. <b>Methods:</b> Pulmonary was induced C57Bl/6J mice with bleomycin (BLM). were...