A5045537369- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Sensors
- Conducting polymers and applications
- Gas Sensing Nanomaterials and Sensors
- bioluminescence and chemiluminescence research
- Nanopore and Nanochannel Transport Studies
University of Washington
2012-2017
Ionis Pharmaceuticals (United States)
2017
Abbott Diabetes Care (United States)
2017
Diabetes Care Center
2017
Abbott (United States)
2017
The dynamic collision behavior of the electro-oxidation single Ag nanoparticles is observed at Au microelectrodes using stochastic single-nanoparticle amperometry. Results show that an nanoparticle collision/oxidation event typically consists a series 1 to ∼10 discrete "sub-events" over ∼20 ms interval. also undergo only partial oxidation prior diffusing away from electrode into bulk solution. Both behaviors are characterized and shown exist under variety experimental conditions. These...
Here we report the voltammetric study of coupled electrochemical reactions on microelectrodes and nanoelectrodes in a closed bipolar cell. We use steady-state cyclic voltammetry to discuss overall response electrodes (BPEs) understand its dependence concentration redox species electrode size. Much previous work electroanalytical chemistry has focused an "open" cell with BPE located open microchannel. A BPE, other hand, two poles placed separate compartments remained relatively unexplored...
Recent high-bandwidth recordings of the oxidation and dissolution 35 nm radius Ag nanoparticles at a Au microelectrode show that these undergo multiple collisions with electrode, generating electrochemical current peaks. In time interval between observed peaks, diffuse in solution near electrolyte/electrode interface. Here, we demonstrate simulations random nanoparticle motion, coupled kinetic parameters, quantitatively reproduce experimentally multicurrent peak behavior. Simulations...
Recently, we introduced a new electrochemical imaging technique called fluorescence-enabled microscopy (FFEM). The central idea of FEEM is that closed bipolar electrode utilized to electrically couple redox reaction interest complementary fluorogenic converting an signal into fluorescent signal. This simple strategy enables one use fluorescence observe conventional processes on very large arrays. initial demonstration focused the specific indicator, resazurin, which reduced generate highly...
Fluorescence-enabled electrochemical microscopy (FEEM) is demonstrated as a new technique to image transient concentration profiles of redox species generated on ultramicroelectrodes (UMEs). FEEM converts an electrical signal into optical by electrically coupling conventional reaction fluorogenic reporter closed bipolar electrode. We describe the implementation for diffusion layer imaging and use array thousands parallel electrodes layers UMEs in two three dimensions. This provides way...
Abstract We report a fundamental study on the use of Ru(bpy) 3 2+ ‐based electrogenerated chemiluminescence (ECL) as an optical reporting system for detection redox‐active analytes closed bipolar microelectrodes, focused gaining in‐depth understanding correlation between ECL emission intensity and electrochemical current. demonstrate significant effect that size anodic cathodic poles has resulting signal show how this influences quantitative analyte electrode. By carefully designing geometry...
We introduce a new electrochemical measurement method compatible with an enzymatic biosensor that is capable of analyte sensing down to the low nanomolar concentration regime. This termed accumulation mode and utilizes immobilized redox polymer mediator wired oxidoreductase enzyme store charge during premeasurement step, followed by step in which this accumulated quantified. demonstrate using model glucose sensor show how sensitivity can be modified simply adjusting time duration step....
We are developing a new electrochemical detection method to study redox properties of single molecules. This relies on the use fluorescence amply signal electron-transfer events at electrode/solution interface. A bipolar electrode mechanism is used couple reaction interest fluorogenic reaction. The oxidation or reduction species results in generation highly product opposite pole same electrode, which optically monitored with total-internal reflection microscopy (TIRFM). this allows one...