A5022338199- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Inflammatory Bowel Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Clostridium difficile and Clostridium perfringens research
- Hormonal and reproductive studies
- Immunotherapy and Immune Responses
- Sarcoidosis and Beryllium Toxicity Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Gut microbiota and health
University College London
2021-2023
Karolinska Institutet
2015-2020
Svenska Örtmedicinska Institute
2017
Abstract Testosterone deficiency in men is associated with increased risk for autoimmunity and B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor cells. Male mice lacking androgen receptor have splenic numbers, serum BAFF levels Baff mRNA. by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) spleen, which may be coupled to lower noradrenaline castrated males, as α-adrenergic...
Significance In this study we investigate the origin of protective B-cell response in spleen atherosclerosis. We find an ongoing activation with production antibodies against oxidation-specific epitopes. addition, can be accelerated using apoptotic cells alone that reduce lesion development and serum cholesterol a B-cell–dependent manner. This pinpoints as important organ for atherosclerosis-associated immunity provides novel pathways to use treatment.
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) retained in the arterial wall. CD4 + T cells, some of which recognize peptide components LDL as antigen, are recruited to forming lesion, resulting T-cell activation. Although these cells thought be proatherogenic, immunization reduces experimental animals. These seemingly contradictory findings have hampered development immune-based therapy....
Significance i NKT cells can both provide help and inhibit B cell responses. Our data show that when are activated with the glycolipid agonist αGalCer together inflammatory cytokine IL-18, they switch from regulating autoreactive to promoting their expansion. As a consequence, responses remain unchecked by cells. The has been shown have promising effects administered as an adjuvant achieve better response vaccines, antitumor agent, well in regulation of autoimmunity. results highlight facet...
Abstract Autoimmune diseases are characterized by pathogenic immune responses to self-antigens. In systemic lupus erythematosus (SLE), many self-antigens found in apoptotic cells (ACs), and defects removal of ACs from the body linked a risk for developing SLE. This includes pathological memory that gives rise disease flares. this study, we investigated how AC-derived develops contribution self-memory development lupus-related pathology. Multiple injections without adjuvant into wild-type...
Abstract Scavenger receptor CD36 has been shown to mediate uptake of modified self-antigens such as apoptotic cells and oxidized LDL in macrophages dendritic cells. Interestingly, was discovered be preferentially expressed also on an innate B cell subtype, marginal zone (MZB). Here we investigate the role activation context clearance break tolerance self. We found that formation germinal center autoantibody production response increased load coincide with downregulation MZB. could connection...