A5029875685- Atherosclerosis and Cardiovascular Diseases
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Mental Health Research Topics
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Respiratory viral infections research
- Travel-related health issues
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Global Public Health Policies and Epidemiology
- Systemic Lupus Erythematosus Research
- Galectins and Cancer Biology
- Vaccine Coverage and Hesitancy
- Cardiac pacing and defibrillation studies
- Surgical site infection prevention
- interferon and immune responses
- Surgical Sutures and Adhesives
- Hepatitis Viruses Studies and Epidemiology
- Nausea and vomiting management
- Spinal Dysraphism and Malformations
- Cytomegalovirus and herpesvirus research
Karolinska University Hospital
2014-2023
Karolinska Institutet
2015-2021
National and Kapodistrian University of Athens
2018
Alfa Institute of Biomedical Sciences
2010-2016
CeMM Research Center for Molecular Medicine
2015
Austrian Academy of Sciences
2015
Medical University of Vienna
2015
University Hospital of Larissa
2013
Recent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While link systemic atherosclerosis is well established, implications altered in artery wall are less understood. Pyruvate dehydrogenase kinase (PDK)-dependent inhibition pyruvate (PDH) has been identified as major metabolic step regulating inflammation. Whether PDK/PDH axis plays role vascular inflammation atherosclerotic cardiovascular disease remains unclear.
Atherosclerosis is a chronic inflammatory disease that initiated by the retention and accumulation of low-density lipoprotein in artery, leading to maladaptive response cells from immune system vessel wall. Strong evidence implicates indoleamine 2,3-dioxygenase (IDO), first rate-limiting enzyme kynurenine pathway tryptophan (Trp) degradation, with regulation anti-inflammatory mechanisms different diseases. However, role IDO endogenous degradation Trp have never been directly examined...
The liver is the central organ that responds to dietary cholesterol intake and facilitates release clearance of lipoprotein particles. Persistent hypercholesterolemia leads immune responses against particles drive atherosclerosis. However, effect on hepatic T-cell differentiation remains unknown.To investigate subsets upon hypercholesterolemia.We observed elevated intrahepatic regulatory T (Treg) cell population increased expression transforming growth factor-β1 in liver. Adoptive transfer...
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) retained in the arterial wall. CD4 + T cells, some of which recognize peptide components LDL as antigen, are recruited to forming lesion, resulting T-cell activation. Although these cells thought be proatherogenic, immunization reduces experimental animals. These seemingly contradictory findings have hampered development immune-based therapy....
Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by balance between pro-inflammatory effector T cells and anti-inflammatory regulatory (Treg) cells. However, phenotype function cell subpopulations hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased expression Treg lineage-defining transcription factor FoxP3 among thymocytes splenocytes. elevated level...
Cytomegalovirus (HCMV) contains cholesterol, but how HCMV interacts with host cholesterol metabolism is unknown. We found that, in human fibroblasts, infection increased the efflux of cellular despite reducing abundance ABCA1. Mechanistically, viral protein US28 was acting through CDC42, rearranging actin microfilaments, causing association lipid rafts, and leading to a dramatic change and/or structure rafts. These changes displaced ABCA1 from cell surface created new binding sites for...
Objective- Dyslipidemia is a component of the metabolic syndrome, an established risk factor for atherosclerotic cardiovascular disease, and also observed in various autoimmune chronic inflammatory conditions. However, there are limited opportunities to study impact acquired dyslipidemia on immune pathology. Approach Results- We designed model system that allows conversion state acute hyperlipidemia adult life, so consequences such transition could be observed, through conditionally deleting...
Atherosclerosis is a chronic inflammatory disease involving immunological and metabolic processes. Metabolism of tryptophan (Trp) via the kynurenine pathway has shown immunomodulatory properties ability to modulate atherosclerosis. We identified 3-hydroxyanthranilic acid (3-HAA) as key metabolite Trp modulating vascular inflammation lipid metabolism. The molecular mechanisms driven by 3-HAA in atherosclerosis have not been completely elucidated. In this study, we investigated whether two...
T-cell activation is characteristic during the development of atherosclerosis. While overall responses have been implicated in disease acceleration, regulatory T cells (Tregs) exhibit atheroprotective effects. The expression enzyme indoleamine 2,3-dioxygenase-1 (IDO), which catalyzes degradation tryptophan (Trp) along kynurenine pathway, has induction and expansion Treg populations. Hence, Tregs can reciprocally promote IDO dendritic via reverse signaling mechanisms antigen presentation. In...
The V1 (VHS107.1.42) immunoglobulin heavy chain gene is thought to be critical in producing IgM natural antibodies of the T15-idiotype that protect against both atherosclerosis and infection from Streptococcus pneumoniae. Our aim was determine whether genetic loss increased atherosclerotic plaque burden vivo because a reduction or other atheroprotective antibodies.We crossed VHS107.1.42-deficient mice with atherosclerosis-prone Apoe(-/-) Ldlr(-/-) strains. Although these double knockout...
Sortilin-1, a receptor of the VPS10p family, has been associated with cardiovascular disease in genome-wide association studies. It is implicated lipoprotein metabolism, secretion proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory cytokines. However, its own regulation remains unclear. Chronic inflammation hallmark atherosclerosis absence regulatory T (Treg) cells reduced protein expression sortilin-1 liver. Therefore, we postulated that mediator(s) known to be...
G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in metabolic tissues. Whether GPR35 can influence vascular inflammation atherosclerosis however never tested. Lethally irradiated LdlrKO mice were randomized receive GPR35KO or wild type (WT) bone marrow transplants fed high cholesterol diet eight weeks develop atherosclerosis. WT chimeric presented no difference size of...